Navigation Links
Overexpressed protein converts noninvasive breast cancer into invasive disease
Date:9/8/2009

HOUSTON ― Active, but non-invasive breast cancer is set free to roam as invasive breast cancer when an overexpressed protein converts it to a different cell type, scientists at The University of Texas M. D. Anderson Cancer Center report in the Sept. 9 issue of the journal Cancer Cell.

"We have discovered a key molecular mechanism for the deadly transition of non-invasive breast cancer into invasive disease," said senior author Dihua Yu, M.D., Ph.D., professor in M. D. Anderson's Department of Molecular and Cellular Oncology.

Overexpression of the protein 14-3-3ζ (zeta) launches a molecular cascade that removes bonds that tie the premalignant cells together and hold them in place, converting them from stationary epithelial cells to highly mobile mesenchymal-like cells, Yu and colleagues report. This epithelial-to-mesenchymal transition (EMT) is recognized as a crucial step in metastasis, the spread of cancer to distant organs that causes 90 percent of all cancer deaths.

The researchers show that 14-3-3ζ teams with the oncoprotein ErbB2, also known as HER2, in a two-hit process to convert normal mammary cells to invasive cancer cells.

In addition to identifying this key step in EMT, Yu notes the findings also provide:

  • A biomarker in 14-3-3ζ to identify high-risk patients for more aggressive treatment before their noninvasive breast cancer converts to invasive disease.

  • New therapeutic targets among the components of the molecular pathway launched by 14-3-3ζ. Some drugs already aim at these targets, Yu said.

  • A solution to a puzzling mystery about how a subset of non-invasive breast cancer with excessive presence of a ErbB2/HER2 develops into invasive breast cancer.

Yu and colleagues previously showed that 14-3-3ζ is overexpressed in many other cancer types, like lung, liver, uterine, stomach cancers. "Our findings might hav
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found
2. U of T researchers identify protein
3. Inhibition of NF-kappa B, a key inflammatory protein, reduced radiation toxicity in zebrafish
4. Key Protein May Link Obesity, Diabetes, Heart Woes
5. Cell Biosciences Launches Unique Protein Phosphorylation Assay Service
6. Researchers identify protein involved in causing gum disease, osteoporosis, arthritis
7. Researchers identify new, cancer-causing role for protein
8. Protein May Identify Deadlier Breast Cancer
9. Naked(R) Juice Brings Power to the People With Two New Protein Zone Flavors: Mango and Double Berry
10. Pitt scientists find intrinsic changes in protein shape influence drug binding
11. Plasma protein Therapies Association Focuses Attention on Donors and Facilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... NY (PRWEB) August 20, 2014 Hundreds ... on behalf of women who were allegedly injured due ... forward in New Jersey’s Bergen County Superior Court, Bernstein ... issued on August 15, 2014, the Court has established ... for Mirena lawsuits that are part of the proceeding’s ...
(Date:8/20/2014)... hearts transplanted into baboons survived for more than a ... researchers report. The work is part of efforts ... transplant waiting lists. In this study, scientists transplanted ... genetic engineering and new methods of suppressing the baboons, ... survive for more than a year. The genetic ...
(Date:8/20/2014)... Gray HealthDay Reporter WEDNESDAY, ... rare, colds, flu and other minor infections might trigger a ... children, a new study suggests. Just five out of ... States, said Dr. Heather Fullerton, lead author of the study ... of California, San Francisco Benioff Children,s Hospital. "It seems infections ...
(Date:8/20/2014)... News) -- Loss of brain cells that act as ... have trouble falling and staying asleep, a new study ... especially severe and often results in nighttime confusion and ... data from the Rush Memory and Aging Project, which ... and are being followed until death, at which point ...
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 (HealthDay ... condition that causes a life-threatening irregular heartbeat, a new study ... lower risk of developing atrial fibrillation, compared to women who ... of the Journal of the American Heart Association . ... disorder even if they were obese, the study found. Obesity ...
Breaking Medicine News(10 mins):Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 3Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 4Health News:Pigs' Hearts Beat for a Year in Baboons' Abdomens 2Health News:Study Ties Colds, Flu to Rare Risk of Stroke in Kids 2Health News:Study Ties Colds, Flu to Rare Risk of Stroke in Kids 3Health News:Seniors' Sleep Woes May Be Linked to Loss of Brain Cells 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 2Health News:Exercise May Guard Against Irregular Heartbeat in Older Women 3
... HealthDay Reporter , WEDNESDAY, July 20 (HealthDay News) ... rashes, but the similarities between the two common, distressing ... patients suffering from both ailments (a very rare phenomenon), ... responses that prompt skin flare-ups for both diseases. ...
... Mann HealthDay Reporter , WEDNESDAY, July 20 (HealthDay ... may be heating up. New technology promises to cut costs ... all of your genes and potentially provide a personalized report ... The human genome was first mapped in 2001 and ...
... health, alleviate hunger, raise living standards and empower women ... to play. Jagdev Sharma, a researcher ... Arizona State University,s Biodesign Institute has been investigating the ... villagers in rural Uganda. He reports his findings this ...
... the Breast Health Center at Women & Infants Hospital ... earn a 2011 Breast Cancer Symposium Merit Award from ... Clinical Oncology (ASCO). The award, which recognizes researchers, ... Shannon MacLaughlan, MD, who is also affiliated with The ...
... injuring a muscle through an accident like falling off a ... serious complication. Their muscles start growing bones. ... there was no treatment. But now, research from Northwestern University ... at the University of Pennsylvania shows that a neuropeptide in ...
... American Society for Radiation Oncology (ASTRO) has awarded ... Faculty Career Research Training Award and the Residents/Fellows ... were selected by ASTRO,s Research Evaluation Committee. ... awarded to stimulate interest in radiation research early ...
Cached Medicine News:Health News:Scientists Close in on Origins of Psoriasis, Eczema 2Health News:Scientists Close in on Origins of Psoriasis, Eczema 3Health News:Cheaper DNA Sequencing Coming Closer 2Health News:Cheaper DNA Sequencing Coming Closer 3Health News:A new breed: Highly productive chickens help raise Ugandans from poverty 2Health News:A new breed: Highly productive chickens help raise Ugandans from poverty 3Health News:When injured muscles mistakenly grow bones 2
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces ... is available in its catalogue: ... Control (Sterilization, Disinfection, Testing and Treatment) ... Given the cost of ... has increased for solutions that can ...
(Date:8/20/2014)... NEW YORK , Aug. 20, 2014 /PRNewswire/ ... report is available in its catalogue: ... U.S. IVD Industry http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html ... Care Act" (H.R. 3590) is complex legislation that ... many of its provisions are beginning to take ...
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com ... is available in its catalogue: ... Key Trends and Opportunities to 2018 ... Synopsis The report provides in depth market ... personal accident and health insurance segment, including: ...
Breaking Medicine Technology:The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23
... April 25, 2011 The 2010 Pharmacy Today ... American Pharmacists Association , reveals pharmacists believe that ... was recommended by their pharmacist, 92% of pharmacists walk ... a product selection and the average patient consult takes ...
... Scientific Corporation (NYSE: BSX ) today ... and launch of the ION™ Paclitaxel-Eluting Platinum Chromium ... technology.  The ION Stent System incorporates a unique ... stenting and intended to improve the acute performance ...
Cached Medicine Technology:Pharmacists Offer Guidance on Top Over-The-Counter Medications 2Pharmacists Offer Guidance on Top Over-The-Counter Medications 3Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 2Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 3Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 4Boston Scientific Announces FDA Approval and U.S. Launch of ION™ Platinum Chromium Stent System 5
Ahmed Glaucoma Valve (small size)....
... established. Provides a robust and durable drainage ... on the globe. Pressure Ridge Molteno Implants ... by Tenons tissue, acts as a Pressure ... range of implants allows the surgeon to ...
... a robust and durable drainage system. Preplaced ... globe. Pressure Ridge Molteno Implants have a ... tissue, acts as a Pressure sensitive biological ... implants allows the surgeon to choose the ...
... Baerveldt Glaucoma Implants feature a low ... and reduced complications. The single-quadrant insertion is ... area seton plate to be installed with ... patented fenestrations of the Baerveldt implant were ...
Medicine Products: