Navigation Links
Overcoming resistance to anti-cancer drugs by targeting cell 'powerhouses'
Date:5/22/2013

Re-routing anti-cancer drugs to the "power plants" that make energy to keep cells alive is a promising but long-neglected approach to preventing emergence of the drug-resistant forms of cancer source of a serious medical problem, scientists are reporting. That's the conclusion of a new study published in the journal ACS Chemical Biology.

Shana Kelley and colleagues explain that doxorubicin and other common forms of chemotherapy work by damaging the genes inside the nucleus of cancer cells. Cancer cells divide and multiply faster than surrounding normal cells, making copies of their genes. The drugs disrupt that process. But cancer cells eventually adapt, developing structures that pump out nucleus-attacking drugs before they can work. Kelley's team explored the effects of targeting doxorubicin to the mitochondria, the energy-producing structures in cells that also contain genes.

They describe a re-targeting approach that involved mating doxorubicin with a small piece of protein that made the drug travel to mitochondria instead of the nucleus. The combo killed cancer cells, even those that had developed pumps. Such an approach could work with a whole family of anti-cancer drugs that target the nucleus, the scientists indicate.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. New finding gives clues for overcoming tamoxifen-resistant breast cancer
2. New Bold Step Renovation Stair Treads and Nosings from Martinson-Nicholls Add Slip Resistance to Stairs
3. Duke researchers describe how breast cancer cells acquire drug resistance
4. Consumer Reports Tests: Bacteria on Turkey Raised Without Antibiotics Showed Significantly Less Antibiotic Resistance than Bacteria Conventional Turkey
5. Outpatients, hospital patients face growing, but different problems with antibiotic resistance
6. Resistance is futile: Researchers identify gene that mediates cisplatin resistance in ovarian cancer
7. Princess Margaret breast cancer research finds new drug target companion prognostic test for hormone therapy resistance
8. Ganetespib shows potency against ALK-positive lung cancer and overcomes crizotinib resistance
9. Other stomach microbiota modulate resistance to H. pylori-driven ulcers
10. Tiny RNA molecule may have role in polycystic ovary syndrome, insulin resistance
11. UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... 30, 2015 AVT, the world leader ... is joining forces with leading proofing solutions provider Global ... worldwide printing market. , Under the agreement, ... engine for its offline inspection solutions, which are customized ... and its varying production workflow setups and printing applications. ...
(Date:5/30/2015)... Thousands of aesthetic industry professionals converged in ... the American Society for Aesthetic Plastic Surgery (ASAPS). ... the parent company of one of the fastest expanding ... growth, the one-of-a-kind device just sold its 2 millionth ... in the news for gaining the FDA’s stamp of ...
(Date:5/30/2015)... One of the pervasive problems plaguing ... options available. Often, the ruralness of a location can ... rural areas feeling the crunch of a strained healthcare ... of paying high premiums and copays, Online USA ... physicians via the power of the internet. , ...
(Date:5/30/2015)... May 30, 2015 ProIntro Magnify contains 30 ... and animations. Instantly add an elegant opening title to any ... a range of clean design layouts. ProIntro Magnify is created ... is extremely easy to use. Simply drag a preset into ... on-screen-controls and parameters in the Inspector window then watch as ...
(Date:5/30/2015)... Minnesota (PRWEB) May 30, 2015 ... acquired the Disability Income Associate (DIA) designation to ... The DIA designation is designed for insurance advisors, ... to further their knowledge and expertise associated with ... Earning the DIA designation is only the latest ...
Breaking Medicine News(10 mins):Health News:AVT and Global Vision Collaborate to Offer Cutting-edge Offline Inspection Solutions for Printing Industry 2Health News:AVT and Global Vision Collaborate to Offer Cutting-edge Offline Inspection Solutions for Printing Industry 3Health News:Dr. Paul Vitenas Meets with Zeltiq President and CEO in Montreal 2Health News:Dr. Paul Vitenas Meets with Zeltiq President and CEO in Montreal 3Health News:Online USA Doctors Brings Healthcare to the Masses with New E-Consults 2Health News:Online USA Doctors Brings Healthcare to the Masses with New E-Consults 3Health News:Announcing the release of ProIntro Magnify from Pixel Film Studios. 2Health News:Secura Consultants Expands Disability Insurance Expertise 2
... Studies conducted on the health effects of tea and alcohol ... while the latter can increase the chances of committing a ... effects of green tea, which is claimed to have numerous ... leukemia patients who drank the beverage had an improved clinical ...
... smokers who suffer from withdrawal symptoms at the Queensland's public ... inpatients of all the // public hospitals in the country ... cost, from 1 January 2006. ,As many ... year. ,Nicotine is capable of creating blood ...
... study has indicated that the use of short wide glasses ... to 30% more. This has been published in the ... small glasses than in the narrow tall glasses of the ... by professional bartenders. ,The study involved 198 ...
... Report of the rising rates of infection with C.difficile ... the mutation of the microorganism into a more virulent ... only manifest in individuals with resistance to antibiotics. ... among non-hospitalized patients has created much panic among the ...
... Merck & Co, known as MSD India, has entered into ... to conduct studies on the former's investigational cervical cancer drug, ... development in India. Under the agreement, clinical trials will be ... cervical cancer. ,The vaccine that has been developed by ...
... has revealed that there is no evidence which proves that ... billion by way of lost wages as a result of ... the British Medical Journal recommends moderation while drinking to prevent ... based product, tropisetron, fructose, tolfenamic acid, artichoke, prickly pear, and ...
Cached Medicine News:Health News:Rising Rates Of C.Difficile Infection Among Non-Hospitalized Patients 2Health News:Merck, ICMR to conduct joint trials on cervical cancer vaccine 2
(Date:5/29/2015)... , May 29, 2015 A six-hour certification ... is being presented at the Cannabis World Congress & ... New York, NY .  Taking place on Wednesday, ... dedicated day of education at the leading event on the ... Led by Clover Leaf University, the first cannabis ...
(Date:5/29/2015)... May 28, 2015 Research and Markets ( ... "North America Open System MRI Market - Growth, Trends ... offering. The key players in the industry ... Siemens Healthcare and Toshiba Medical Systems ... replacing CT because of its higher sensitivity and use ...
(Date:5/29/2015)... , May 29, 2015 Eli Lilly ... Goldman Sachs 36th Annual Global Healthcare Conference on Tuesday, ... president and president, Elanco Animal Health, will participate in ... A live audio webcast will be ... investor website at http://investor.lilly.com/events.cfm . A replay of ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4North America Open System MRI Market 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare and Toshiba Medical Dominating 2Lilly to Participate in Goldman Sachs Global Healthcare Conference 2
... AutoGenomics, a leader in,developing automated molecular testing solutions, ... submitted to the FDA for 510(k) clearance,late last ... Medical,School-Partners HealthCare Center for Genetics and Genomics (HPCGG). ... prescribed to help prevent,blood clots. With more than ...
... against osteoporosis-related fractures, including spine and hip, - Reclast reduced spine ... placebo in study published in New England Journal of Medicine, - Unique once-yearly ... ... - Osteoporotic fractures affect one in two women over 50(1) and are ...
Cached Medicine Technology:Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity 2Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 2Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 3Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 4Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 5Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 6
... PelviSoft® Acellular Collagen BioMesh, provides ... tissue together with the porosity of ... for use in pelvic floor reconstruction. ... and cystocele prolapse, where plication alone ...
... Allograft meets the demanding ... floor reconstructive procedures, and ... suture pull-through, demonstrating long-term ... a structural support for ...
The High Pure Viral RNA Kit is intended for general laboratory use and is designed to purify viral RNA from serum or plasma. Viral RNA is used for RT-PCR analysis directly after elution in nuclease-f...
... The QIAamp Viral RNA Mini ... nucleic acids from cell-free fluid ... acids that can be isolated ... are not limited to, RNA ...
Medicine Products: