Navigation Links
Overcoming light scattering: New optical system sees deeper inside tissue
Date:7/2/2014

Optical imaging methods are rapidly becoming essential tools in biomedical science because they're noninvasive, fast, cost-efficient and pose no health risks since they don't use ionizing radiation. These methods could become even more valuable if researchers could find a way for optical light to penetrate all the way through the body's tissues. With today's technology, even passing through a fraction of an inch of skin is enough to scatter the light and scramble the image.

Now a team of researchers from Spain's Jaume I University (UJI) and the University of Valncia has developed a single-pixel optical system based on compressive sensing that can overcome the fundamental limitations imposed by this scattering. The work was published today in The Optical Society's (OSA) open-access journal Optics Express.

"In the diagnostic realm within the past few years, we've witnessed the way optical imaging has helped clinicians detect and evaluate suspicious lesions," said Jess Lancis, the paper's co-author and a researcher in the Photonics Research Group at UJI. "The elephant in the room, however, is the question of the short penetration depth of light within tissue compared to ultrasound or x-ray technologies. Current knowledge is insufficient for early detection of small lesions located deeper than a millimeter beneath the surface of the mucosa."

"Our goal is to see deeper inside tissue," he added.

To achieve this, the team used an off-the-shelf digital micromirror array from a commercial video projector to create a set of microstructured light patterns that are sequentially superimposed onto a sample. They then measure the transmitted energy with a photodetector that can sense the presence or absence of light, but has no spatial resolution. Then they apply a signal processing technique called compressive sensing, which is used to compress large data files as they are measured. This allows them to reconstruct the image.

One of the most surprising aspects of the team's work is that they use essentially a single-pixel sensor to capture the images. While most people think that more pixels result in better image quality, there are some cases where this isn't true, Lancis said. In low-light imaging, for instance, it's better to integrate all available light into a single sensor. If the light is split into millions of pixels, each sensor receives a tiny fraction of light, creating noise and destroying the image.

"Something similar happens when you try to transmit images through scattering media," Lancis said. "When we use a conventional digital camera to get an image, we only see the familiar noisy pattern known as 'speckle.' In compressive imaging, since we aren't using pixelated sensors, it should be less sensitive to light scrambling and enable transmission of images through scattering."

Also notable, the team's technique could operate through dynamic scattering. "Most scattering media of interest, like biological tissue, are dynamic in the sense that the scatter centers continuously change their positions with time -- meaning that the speckle patterns are 'in motion.' This is ideal for some applications because monitoring the changes of the speckle can reveal information about the sample, but the drawback is that it's a major nuisance to transmit or get images," Lancis pointed out. "Our technique, however, requires no calibration of the medium, and its fluctuations during the sensing stage don't limit imaging ability."

What's ahead for the team? "Our next goal is to break the barriers of light penetration depth inside a scattering medium with the state-of-the-art megapixel-programmable spatial light modulators used in consumer electronics," Lancis says. To do this, they'll need to demonstrate that their technique works even when the sample is embedded inside the tissue.


'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
The Optical Society
Source:Eurekalert  

Related medicine news :

1. Rules of thumb: 3 simple ideas for overcoming childhood obesity
2. Overcoming structural uncertainty in computer models
3. “Tips on How to Overcome Fear of Failure,” A New Article on Vkool.com, Share Useful Tips with Readers on Overcoming the Fear of Failure - V-kool
4. Overcoming Emotional Eating
5. How “Reveal The Thin Within” Helps People Get Rid Of Fat – V kool
6. Lynn Gauthier Offers Personal Stories of Overcoming Vanity
7. Diabetes drug points the way to overcoming drug resistance in melanoma
8. Joe Jones, Personal Trainer to Seva Call Founder Shares Tips on Overcoming Gym Intimidation
9. Overcoming resistance to anti-cancer drugs by targeting cell powerhouses
10. New finding gives clues for overcoming tamoxifen-resistant breast cancer
11. Enlightening cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Overcoming light scattering: New optical system sees deeper inside tissue
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors ... on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, ... to helping service members that have been wounded in battle and their families. Venture ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
Breaking Medicine Technology: