Navigation Links
Overcoming inhibitors of cell death improves cancer therapy efficacy
Date:8/1/2008

Individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumor, have an extremely poor prognosis. Although pre-clinical studies indicated therapeutics inhibiting a group of proteins known as receptor tyrosine kinases (RTKs) would likely be beneficial to individuals with GBM, these RTK inhibitors have met with limited clinical success only a small proportion of patients respond to such treatment and most subsequently relapse after only a short time. New data, generated by Andrew Kung and colleagues, at the Dana-Farber Cancer Institute, Boston, have now provided insight into the mechanism by which GBM cells become resistant to RTK inhibitors and have suggested a way to improve the efficacy of RTK inhibitors in this clinical setting.

In the study, human GBM cells exposed in vitro to an inhibitor of the RTK PDGFR activated a cellular pathway that usually induces cells to undergo a form of cell death known as apoptosis, but the final steps of the pathway were not completed, meaning that the cells did not die. Further analysis revealed that the final steps of this pathway were blocked by a group of proteins known as IAPs. Consistent with this, if the PDGFR inhibitor was combined with an IAP inhibitor the GBM cells underwent apoptosis. Further, this drug combination showed enhanced efficacy at inhibiting tumor growth in an orthotopic mouse model of GBM. The authors therefore suggest that combining drugs targeting IAPs with RTK inhibitors might prove beneficial to individuals with GBM.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Overcoming Im in Control Syndrome and Providing Help When Patients Least Expect It Can Benefit Children and Teens With Asthma
2. VH1 Teams Up with Dr. Drew for Celebrity Rehab With Dr. Drew, a Series Depicting the Process of Overcoming Addiction
3. Cell skeleton may hold key to overcoming drug resistance in cancer
4. Myostatin inhibitors may improve recovery of wartime limb injuries
5. Team discovers new inhibitors of estrogen-dependent breast cancer cells
6. FDA Approves NOVO NORDISKs NovoSeven(R) RT (Coagulation Factor VIIa [Recombinant] Room Temperature Stable) for Hemophilia Patients With Inhibitors
7. Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
8. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
9. Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
10. Silencing small but mighty cancer inhibitors
11. Sleep Apnea Boosts Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... Usually, the impending arrival of warmer ... for those self-conscious about a double chin, this means more anxiety than elation. The ... , “For most people, a double chin is undesirable,” Dr. Goldman said, “but it ...
(Date:3/28/2017)... Greifensee, Switzerland (PRWEB) , ... March 28, 2017 ... ... testing for laboratory instruments are critical to ensuring high-quality results and maintaining GMP ... and Qualification of Laboratory Instruments in accordance with GMP requirements " these requirements ...
(Date:3/28/2017)... ... March 28, 2017 , ... Qualidigm ... its corporate headquarters to a new, more expansive office space in order to ... Qualidigm purchased a distressed office building in Wethersfield, Conn. located at 936 Silas ...
(Date:3/28/2017)... ... March 28, 2017 , ... With less than 10,000 dermatologists ... to quality care can be limited while the desire to conquer breakouts and eliminate ... acne care for every customer online, today released its inaugural survey on the State ...
(Date:3/28/2017)... WI (PRWEB) , ... March 28, 2017 , ... ... self-funded health plans work, the Self-Funding Success website has recently developed and published ... Self-Funded Health Plans ” was created based on common inquiries the site’s team ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... March 27, 2017 To mark the end of ... Inc., a leader in digital imaging solutions, will showcase Canon ... held at New York,s Jacob Javits ... Vision Month, sponsored by the American Optometric Association, is observed ... of receiving comprehensive eye exams. In recognition of this observance, ...
(Date:3/27/2017)... new survey from the American Association of ... (CBP) significantly reduced beneficiary choice and access to commonly ... beneficiaries to switch to unfamiliar or unsuitable testing systems, ... AADE,s survey is the latest in a continuous round ... inherent problems with the CBP. Last year, a National ...
(Date:3/27/2017)... , March 27, 2017 FinancialBuzz.com News Commentary  ... Based on New ... in states where cannabis is legal will generate $655 million in ... be from cannabis specific taxes, such as Washington State,s ... will be earned from state sales taxes that are applied on ...
Breaking Medicine Technology: