Navigation Links
Overcoming inhibitors of cell death improves cancer therapy efficacy
Date:8/1/2008

Individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumor, have an extremely poor prognosis. Although pre-clinical studies indicated therapeutics inhibiting a group of proteins known as receptor tyrosine kinases (RTKs) would likely be beneficial to individuals with GBM, these RTK inhibitors have met with limited clinical success only a small proportion of patients respond to such treatment and most subsequently relapse after only a short time. New data, generated by Andrew Kung and colleagues, at the Dana-Farber Cancer Institute, Boston, have now provided insight into the mechanism by which GBM cells become resistant to RTK inhibitors and have suggested a way to improve the efficacy of RTK inhibitors in this clinical setting.

In the study, human GBM cells exposed in vitro to an inhibitor of the RTK PDGFR activated a cellular pathway that usually induces cells to undergo a form of cell death known as apoptosis, but the final steps of the pathway were not completed, meaning that the cells did not die. Further analysis revealed that the final steps of this pathway were blocked by a group of proteins known as IAPs. Consistent with this, if the PDGFR inhibitor was combined with an IAP inhibitor the GBM cells underwent apoptosis. Further, this drug combination showed enhanced efficacy at inhibiting tumor growth in an orthotopic mouse model of GBM. The authors therefore suggest that combining drugs targeting IAPs with RTK inhibitors might prove beneficial to individuals with GBM.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Overcoming Im in Control Syndrome and Providing Help When Patients Least Expect It Can Benefit Children and Teens With Asthma
2. VH1 Teams Up with Dr. Drew for Celebrity Rehab With Dr. Drew, a Series Depicting the Process of Overcoming Addiction
3. Cell skeleton may hold key to overcoming drug resistance in cancer
4. Myostatin inhibitors may improve recovery of wartime limb injuries
5. Team discovers new inhibitors of estrogen-dependent breast cancer cells
6. FDA Approves NOVO NORDISKs NovoSeven(R) RT (Coagulation Factor VIIa [Recombinant] Room Temperature Stable) for Hemophilia Patients With Inhibitors
7. Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
8. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
9. Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
10. Silencing small but mighty cancer inhibitors
11. Sleep Apnea Boosts Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 16, 2017 , ... Vixiar Medical, ... of the medical device company, effective immediately. , “This is perfect timing for ... a strong track record in medical device market development and revenue growth, particularly ...
(Date:1/15/2017)... ... 2017 , ... Whole Health Supply, LLC is announcing the release of an updated version of ... purchase. , The 2017 edition has wide jaws that will accommodate nails up to ... well as diabetics. This handle is reinforced for extra strength when pressing down on dense ...
(Date:1/15/2017)... ... January 14, 2017 , ... Wondering where to go this Valentine's ... to your door for a romantic, lobster feast in the comfort of your own ... Day. The dinners will be featured until February 15th, 2017. , Romantic Dinner ...
(Date:1/14/2017)... ... January 13, 2017 , ... According to ... magnesium-rich Mediterranean diet may lower the risk of type 2 diabetes, Alzheimer’s, and ... many health and wellness benefits linked to a Mediterranean diet are only some ...
(Date:1/13/2017)... , ... January 13, 2017 , ... The 18th European ... America hotel on March 3-4, 2017. This Congress is expertly designed to meet ... management of patients with lung cancer. , Chaired by Dr. Giorgio V. Scagliotti, Professor ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... , January 16, 2017 Bill is an ... of general management and leadership positions with global medical device companies, ... strong track record of launching new products and building successful businesses ... , Africa and North America ... Educated ...
(Date:1/16/2017)... 2017 CBDRx, the world,s premiere nutraceutical hemp ... rich hemp extract to Veteran,s groups across the country. ... hemp extract to Veteran,s groups across the United States.  ... in the world and through their passion, CBDRx honors ... phyto-nutrient rich hemp extract available. ...
(Date:1/13/2017)... Inc. ("InMed") (CSE: IN; OTCQB: IMLFF), today announced that ... at Eli Lilly & Company, has been appointed to InMed ... years of senior financial and executive leadership to InMed,s Board ... ... leadership position in financial and business expertise with one of ...
Breaking Medicine Technology: