Navigation Links
Overactive Blood Platelets May Play Role in Lupus
Date:9/1/2010

By Melissa Lee Phillips
HealthDay Reporter

WEDNESDAY, Sept. 1 (HealthDay News) -- Overactive blood platelets could trigger inflammation in those with lupus, but the anti-clotting drug Plavix might ease the painful symptoms of this autoimmune disease, a new study suggests.

Platelets, which are the colorless, disc-shaped blood cells that are key to clotting, are suspected to be involved in lupus, explained senior study author Dr. Patrick Blanco, of the University of Bordeaux in France, but "their precise role was poorly understood until now."

Systemic lupus erythematosus (SLE) is a chronic disease thought to develop when the body's own antibodies start attacking organs. Sufferers experience recurring pain and inflammation in many parts of their body. Some common symptoms include joint pain or swelling, muscle pain, fever with no known cause, and red rashes, often on the face, according to the U.S. National Library of Medicine.

The exact cause of lupus is unknown, although research suggests that both environmental and genetic factors contribute to the disease.

Presently, there is no cure for the disease, which can be fatal. Current treatments include steroids and chemotherapy-like drugs, but they have assorted toxic effects, the study authors noted.

Blanco and his colleagues theorized that blood platelets might be involved in lupus because of their known role in the inflammatory process. To test this theory, they examined the blood of 37 lupus patients and compared their platelets to those from individuals without the disease.

They found that platelets in people with lupus were abnormally "activated" -- they expressed too much of a protein that's involved in blood clotting. These activated platelets, in turn, triggered production of proteins called interferons, which are known to promote inflammation.

The authors found that destroying blood platelets in mice prone to lupus relieved symptoms of the disease. They also treated these mice with the antiplatelet drug clopidogrel (Plavix), which is commonly used in humans to treat heart disease and stroke. The mice showed reduced lupus symptoms and they lived three months longer than mice that weren't treated with the drug.

The results suggest that it's possible that such anti-clotting drugs could improve outcomes in patients with lupus, said Blanco. He and his colleagues are currently designing clinical trials in humans to test this possibility.

The study finding was published in the Sept. 1 issue of Science Translational Medicine.

More information

There's more on lupus at the Lupus Foundation of America.

SOURCES: Patrick Blanco, M.D., Ph.D., University of Bordeaux, France; Sept. 1, 2010, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Overactive Thyroid Linked to Stroke in Young Adults
2. McMaster study contradicts reports of problems with blood-thinner
3. Even modest weight gain can harm blood vessels, Mayo researchers find
4. Novel role: EZH2 boosts creation of ovarian cancer blood vessels
5. Scientists map epigenetic changes during blood cell differentiation
6. Selected cells from blood or bone marrow may provide a route to healing blood vessels
7. Just a Little Belly Fat Can Damage Blood Vessels
8. Caltech biologists discover microRNAs that control function of blood stem cells
9. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
10. Experts Support FDA Panels Backing of New Blood Thinner
11. Implantable Sensor Measures Blood Sugar Levels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Overactive Blood Platelets May Play Role in Lupus
(Date:5/4/2016)... ... May 04, 2016 , ... ... support for knees, ankles, and elbows. Engineered with athletes in mind, OMNIFORCE ... manufacturing (opposed to ineffective circular knitting, common in the industry) produces premium ...
(Date:5/4/2016)... ... May 04, 2016 , ... With the stamp of approval from the ... May as National Cancer Research Month. According to the American Cancer Society (2016) ... predications of one in four Americans dying as a result. , With numbers as ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... Group is scheduled on July 25-27, 2016 at Las Vegas. It aims to ... professionals from educational institutes and research organizations across the globe; making the conference ...
(Date:5/3/2016)... ... May 04, 2016 , ... An accurate ... reaching the global health community through expanding activities that embrace training, standards, technology ... the resource-limited countries. , In support of this important work, ASCP ...
(Date:5/3/2016)... ... 03, 2016 , ... In April, Amerec launched a new website designed with ... the best steam and sauna solutions. , First, the Amerec website has been redesigned ... all of the site’s features, especially the Steam Builder Tool , to both ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... DUBLIN , May 3, 2016 ... to pay $55 million to a woman who says ... State court awarded Gloria Ristesund $5 million ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... of accusations against the company. In February, the same ...
(Date:5/3/2016)... 2016 Global and Chinese ... basic overview of the industry that covers definition, ... mesh report explores into the international and Chinese ... on Surgical Mesh market spread across 150 pages ... figures is available at http://www.reportsnreports.com/reports/470569-global-and-chinese-surgical-mesh-industry-2016-market-research-report.html . ...
(Date:5/2/2016)... 2016  While nearly three-quarters of Americans (71%) are ... their health, only about half report taking any steps ... of a new survey announced today by Hologic (Nasdaq: ... National Osteoporosis Month, Hologic is raising awareness of this ... million Americans. Osteoporosis is a disease that ...
Breaking Medicine Technology: