Navigation Links
Overactive Blood Platelets May Play Role in Lupus
Date:9/1/2010

By Melissa Lee Phillips
HealthDay Reporter

WEDNESDAY, Sept. 1 (HealthDay News) -- Overactive blood platelets could trigger inflammation in those with lupus, but the anti-clotting drug Plavix might ease the painful symptoms of this autoimmune disease, a new study suggests.

Platelets, which are the colorless, disc-shaped blood cells that are key to clotting, are suspected to be involved in lupus, explained senior study author Dr. Patrick Blanco, of the University of Bordeaux in France, but "their precise role was poorly understood until now."

Systemic lupus erythematosus (SLE) is a chronic disease thought to develop when the body's own antibodies start attacking organs. Sufferers experience recurring pain and inflammation in many parts of their body. Some common symptoms include joint pain or swelling, muscle pain, fever with no known cause, and red rashes, often on the face, according to the U.S. National Library of Medicine.

The exact cause of lupus is unknown, although research suggests that both environmental and genetic factors contribute to the disease.

Presently, there is no cure for the disease, which can be fatal. Current treatments include steroids and chemotherapy-like drugs, but they have assorted toxic effects, the study authors noted.

Blanco and his colleagues theorized that blood platelets might be involved in lupus because of their known role in the inflammatory process. To test this theory, they examined the blood of 37 lupus patients and compared their platelets to those from individuals without the disease.

They found that platelets in people with lupus were abnormally "activated" -- they expressed too much of a protein that's involved in blood clotting. These activated platelets, in turn, triggered production of proteins called interferons, which are known to promote inflammation.

The authors found that destroying blood platelets in mice prone to lupus relieved symptoms of the disease. They also treated these mice with the antiplatelet drug clopidogrel (Plavix), which is commonly used in humans to treat heart disease and stroke. The mice showed reduced lupus symptoms and they lived three months longer than mice that weren't treated with the drug.

The results suggest that it's possible that such anti-clotting drugs could improve outcomes in patients with lupus, said Blanco. He and his colleagues are currently designing clinical trials in humans to test this possibility.

The study finding was published in the Sept. 1 issue of Science Translational Medicine.

More information

There's more on lupus at the Lupus Foundation of America.

SOURCES: Patrick Blanco, M.D., Ph.D., University of Bordeaux, France; Sept. 1, 2010, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Overactive Thyroid Linked to Stroke in Young Adults
2. McMaster study contradicts reports of problems with blood-thinner
3. Even modest weight gain can harm blood vessels, Mayo researchers find
4. Novel role: EZH2 boosts creation of ovarian cancer blood vessels
5. Scientists map epigenetic changes during blood cell differentiation
6. Selected cells from blood or bone marrow may provide a route to healing blood vessels
7. Just a Little Belly Fat Can Damage Blood Vessels
8. Caltech biologists discover microRNAs that control function of blood stem cells
9. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
10. Experts Support FDA Panels Backing of New Blood Thinner
11. Implantable Sensor Measures Blood Sugar Levels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Overactive Blood Platelets May Play Role in Lupus
(Date:5/28/2017)... ... May 28, 2017 , ... ... is proud to announce that Jorge Fernandez-Silva, M.D., has joined its new Melbourne ... a specialty that concentrates on minimally invasive techniques to treat and manage many ...
(Date:5/27/2017)... ... ... In any business, follow up is critical to success. It is the same ... there will always be some patients who can’t or won’t make a immediate decision. ... it comes to presenting treatment. After the patient leaves, most practices end up ...
(Date:5/26/2017)... Boston, Massachsetts (PRWEB) , ... May 26, 2017 ... ... communities will gather at Boston CEO 2017 on May 30th and 31st at ... off-the-record networking forum for leading executives in the life sciences, offering exclusive access ...
(Date:5/26/2017)... SARASOTA, Fla. (PRWEB) , ... May 26, 2017 ... ... providers of premium delicatessen foods, is sharing bold recipes for Memorial Day entertaining ... to your menus. , “Boar’s Head fresh sliced meats and cheeses featured ...
(Date:5/26/2017)... , ... May 26, 2017 , ... Silver Birch of ... which is located on more than four acres of land at 5620 Sohl Avenue ... , The 103,000 square-foot building includes 125 studio and one-bedroom apartments. Each of the ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)...  In response to the opioid epidemic in ... working with Pfizer to make up to 1 million ... community health centers, free and charitable clinics, public health ... "Pfizer has a long-standing commitment to improving health outcomes ... through educational activities," said Caroline Roan , vice ...
(Date:5/23/2017)... , May 23, 2017  Leaf Healthcare, ... innovative medical devices for pressure ulcer prevention, will ... American Association of Critical Care Nurses, National Teaching ... 22-25. The Leaf Patient Monitoring System ... for the hospital environment.  The system seamlessly tracks ...
(Date:5/22/2017)... MAITLAND, Fla. , May 22, 2017 /PRNewswire/ ... industry as a whole continue to make the ... evidence becomes increasingly important for ensuring positive patient ... Key industry stakeholders are shifting focus away from ... results and effects of long-term specialty drug therapy ...
Breaking Medicine Technology: