Navigation Links
Overactive Blood Platelets May Play Role in Lupus

By Melissa Lee Phillips
HealthDay Reporter

WEDNESDAY, Sept. 1 (HealthDay News) -- Overactive blood platelets could trigger inflammation in those with lupus, but the anti-clotting drug Plavix might ease the painful symptoms of this autoimmune disease, a new study suggests.

Platelets, which are the colorless, disc-shaped blood cells that are key to clotting, are suspected to be involved in lupus, explained senior study author Dr. Patrick Blanco, of the University of Bordeaux in France, but "their precise role was poorly understood until now."

Systemic lupus erythematosus (SLE) is a chronic disease thought to develop when the body's own antibodies start attacking organs. Sufferers experience recurring pain and inflammation in many parts of their body. Some common symptoms include joint pain or swelling, muscle pain, fever with no known cause, and red rashes, often on the face, according to the U.S. National Library of Medicine.

The exact cause of lupus is unknown, although research suggests that both environmental and genetic factors contribute to the disease.

Presently, there is no cure for the disease, which can be fatal. Current treatments include steroids and chemotherapy-like drugs, but they have assorted toxic effects, the study authors noted.

Blanco and his colleagues theorized that blood platelets might be involved in lupus because of their known role in the inflammatory process. To test this theory, they examined the blood of 37 lupus patients and compared their platelets to those from individuals without the disease.

They found that platelets in people with lupus were abnormally "activated" -- they expressed too much of a protein that's involved in blood clotting. These activated platelets, in turn, triggered production of proteins called interferons, which are known to promote inflammation.

The authors found that destroying blood platelets in mice prone to lupus relieved symptoms of the disease. They also treated these mice with the antiplatelet drug clopidogrel (Plavix), which is commonly used in humans to treat heart disease and stroke. The mice showed reduced lupus symptoms and they lived three months longer than mice that weren't treated with the drug.

The results suggest that it's possible that such anti-clotting drugs could improve outcomes in patients with lupus, said Blanco. He and his colleagues are currently designing clinical trials in humans to test this possibility.

The study finding was published in the Sept. 1 issue of Science Translational Medicine.

More information

There's more on lupus at the Lupus Foundation of America.

SOURCES: Patrick Blanco, M.D., Ph.D., University of Bordeaux, France; Sept. 1, 2010, Science Translational Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Overactive Thyroid Linked to Stroke in Young Adults
2. McMaster study contradicts reports of problems with blood-thinner
3. Even modest weight gain can harm blood vessels, Mayo researchers find
4. Novel role: EZH2 boosts creation of ovarian cancer blood vessels
5. Scientists map epigenetic changes during blood cell differentiation
6. Selected cells from blood or bone marrow may provide a route to healing blood vessels
7. Just a Little Belly Fat Can Damage Blood Vessels
8. Caltech biologists discover microRNAs that control function of blood stem cells
9. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
10. Experts Support FDA Panels Backing of New Blood Thinner
11. Implantable Sensor Measures Blood Sugar Levels
Post Your Comments:
Related Image:
Overactive Blood Platelets May Play Role in Lupus
(Date:11/25/2015)... ... November 26, 2015 , ... ... (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and public R&D ... Nairobi (UNON) for the opening of the 5th African Network for Drugs and ...
(Date:11/25/2015)... , ... November 25, 2015 , ... For the first ... “ Two Organizations, One Beat ” campaign. The partnership between the two groups began ... aid in MAP International’s cause. , MAP International was founded in 1954 and is ...
(Date:11/25/2015)... ... November 25, 2015 , ... Lakeview Health, a Jacksonville-based ... celebrate their sobriety and show through pictures what a positive difference it makes. ... Thanksgiving with the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram accounts. ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 25, 2015, ... for the Narconon network, announced the release of a new cutting edge recovery program ... organization has been working with drug- and alcohol-addicted individuals with the purpose to free ...
(Date:11/25/2015)... ... November 25, 2015 , ... The McHenry County law firm of ... obtained by Attorneys Francisco J. Botto and Alex C. Wimmer. Attorneys Botto and Wimmer ... 2015 IL App (2d) 130884WC. , According to court documents, Adcock testified that on ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Japanese therapeutic drug monitoring market, including emerging ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the Global Cell Surface Testing Market: ... report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... November 26, 2015 ... universitetssjukhus ser potential att använda SyMRI för ... för patienter med multipel skleros (MS) ... med SyntheticMR AB för att kunna använda ... sjukhuset. Med SyMRI kan man generera flera ...
Breaking Medicine Technology: