Navigation Links
Over-activity of enzyme HDAC6 exacerbates symptoms of Amyotrophic Lateral Sclerosis
Date:6/26/2014

Scientists at VIB and KU Leuven have demonstrated in fruit-flies that over-activity of the enzyme HDAC6 in the nerve ends exacerbates the symptoms of the neurodegenerative condition Amyotrophic Lateral Sclerosis (ALS / Lou Gehrig's Disease). Inhibition of this enzyme could offer a protective effect against ALS.

Patrik Verstreken (VIB/KU Leuven): "Nobody wants to suffer from a degenerative condition such as amyotrophic lateral sclerosis (ALS), in which you lose coordination of all muscles through gradual damage to the nerve cells. ALS patients are conscious throughout the disease process, including death by suffocation. Any additional insight into the dysfunction of nerve cells and the defective transmission of signals to the muscles paves the way to further targeted ALS research."

Amyotrophic Lateral Sclerosis a degenerative process

In patients with ALS, the nerve cells that allow for the synaptic transmission die off. Synaptic transmission is the transmission of signals to the muscles, which is essential for the coordination of the muscles. ALS falls under the collective term of neurodegenerative conditions, which includes diseases such as Parkinson's disease. It is a progressive, debilitating neurological disease for which there is currently no treatment available. ALS patients are very aware of the entire process. ALS patients often opt for euthanasia in order to avoid suffocating to death as the respiratory muscles also fail in the end.

Over-activity HDAC6

Katarzyna Miskiewicz, Liya Jose and Patrik Verstreken have studied how this type of nerve cell becomes defective in fruit-flies that express a form of ALS. Fruit-flies are a very suitable model organism for neurological research. In the case of ALS, the specific defect is located at the nerve endings, where the investigators discovered an over-activity of the enzyme HDAC6. This over-activity of HDAC6 is a cause of the disrupted synaptic transmission, resul
'/>"/>

Contact: Sooike Stoops
sooike.stoops@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Enzyme corrects more than 1 million faults in DNA replication
2. Enzyme offers new therapeutic target for cancer drugs
3. Clemson researchers collect and reuse enzymes while maintaining bioactivity
4. Enzymes implicated in disease processes attack one another instead of harming body proteins
5. Compounds activate key cancer enzyme to interfere with tumor formation
6. Mayo Clinic researchers identify new enzyme to fight Alzheimers disease
7. Structure of enzyme unravelled providing basis for more accurate design of chemotherapeutic drugs
8. Gateway enzyme for chemicals from catnip to cancer drug
9. Enzyme explains angina in diabetics
10. Synchrotron gives insight into green energy enzymes
11. Enzymes may point toward better therapies for prediabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... , ... August 04, 2015 , ... ... contemporary look at unique artistic expressions from a diverse group of exceptionally talented ... Is Beautiful Music & Art Festival on September 25-27, 2015 in Downtown Las ...
(Date:8/4/2015)... , ... August 04, 2015 ... ... HealthCenter personal health record (PHR) product has achieved Office of the National ... EHR Certification from Drummond Group. HealthCenter delivers the highest quality personal health ...
(Date:8/4/2015)... Boston, MA (PRWEB) , ... August 04, 2015 ... ... assume that getting older brings an automatic end to driving, says the August ... if a person is okay to drive. It requires an individual assessment of ...
(Date:8/4/2015)... ... 2015 , ... METTLER TOLEDO has announced an upcoming online ... Lubrizol, Pfizer, and Merck. This free online seminar will be held on ... require informed decisions with limited process understanding. Established methods have been developed ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... in which the physician is board-certified is increasingly influential in their choice of ... , The 2015 ASDS Consumer Survey on Cosmetic Dermatologic Procedures reflects overall consumer ...
Breaking Medicine News(10 mins):Health News:Sin City Gallery Rocks Life Is Beautiful Festival with INTIMATELY FEMALE at Art Motel 2Health News:Sin City Gallery Rocks Life Is Beautiful Festival with INTIMATELY FEMALE at Art Motel 3Health News:Sin City Gallery Rocks Life Is Beautiful Festival with INTIMATELY FEMALE at Art Motel 4Health News:MedicaSoft's HealthCenter Earns ONC-HIT Certification from Drummond Group 2Health News:MedicaSoft's HealthCenter Earns ONC-HIT Certification from Drummond Group 3Health News:Assessment Can Help Older Drivers Keep Driving Safely, from the August 2015 Harvard Health Letter 2Health News:METTLER TOLEDO Announces New Process Chemistry and Scale-up Online Seminar 2Health News:ASDS Survey: Half of Consumers Considering Cosmetic Procedure 2Health News:ASDS Survey: Half of Consumers Considering Cosmetic Procedure 3Health News:ASDS Survey: Half of Consumers Considering Cosmetic Procedure 4
... A new study by researchers at,NutritionQuest ( http://www.nutritionquest.com ) ... a low-cost emailed health promotion,program, "Alive!" significantly improved self-reported ... The researchers also found improvement in "presenteeism," a ... productivity and the,ability to accomplish work tasks. , ...
... and OTTAWA, Nov. 20 Today, Natural,Nutrition, Inc. (OTC ... $2,062,452 (unaudited) for the first nine months of,2008 through ... first,nine months of 2007. These numbers are unaudited ... in the first nine months of 2008 may,be found ...
... for an easy,fun and inexpensive way to stay fit ... Kideosyncrasy Vol.2 ( www.kideosyncrasy.com ) is a fun tool ... is jam-packed with live-action;,kids-teaching-kids how to easily step into ... tips on nutrition and exercise, Kideosyncrasy,promotes health and fitness ...
... at National Capital Philanthropy Day Awards , ... ... W. Lintott, chairman of the board of the Children,s Hospital ... Fundraising Volunteer" at the National Capital Philanthropy Day Awards presented ...
... Balog is celebrating his one Year Anniversary as a Non-Smoker 60 Pounds Lighter. ... enough to quit smoking or lose 60 pounds but to do both within ... help, Joe was able to turn his life around and improve his quality ... success. , ...
... budget cutbacks are becoming commonplace as most Americans struggle to ... should not be among the forfeited services. Recent research indicates ... on medical visits to save money and The Vision Council ... , "During this economic crisis, ...
Cached Medicine News:Health News:NutritionQuest's Alive! Program Improves Quality of Life 2Health News:Natural Nutrition Reports Comprehensive Income of $2,062,452 Through Third Quarter, 2008 2Health News:Give Kids the Gift of Fun and Fitness This Holiday Season 2Health News:James W. Lintott Named Outstanding Fundraising Volunteer Of The Year 2Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 2Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 3Health News:Even in Poor Economy, Consumers Urged to Prioritize Health Care 2
(Date:8/4/2015)... and LOS ANGELES , Aug. ... DGX ), the world,s leading provider of diagnostic ... the previously announced acquisition of MemorialCare Health System,s ... a result of the transaction, patients and physicians ... innovative services and network of nearly 200 patient ...
(Date:8/4/2015)... , Aug. 4, 2015  The Pittsburgh Life Sciences ... firm, announced today that one of its portfolio companies, ... their Flex ® Robotic System in the U.S.  ... more proud of Medrobotics," said John W. Manzetti ... a very long way since spinning out of The ...
(Date:8/4/2015)... 4, 2015  Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ... $18.9 million for the three and six months ended ... of $12.1 million and $43.4 million for the same ... driven primarily by the more than $90 million of ... the upfront payment from Bayer to license  ISIS-FXI Rx ...
Breaking Medicine Technology:Quest Diagnostics Completes Acquisition of MemorialCare Health System's Laboratory Outreach Service Business in Southern California 2Pittsburgh Life Sciences Greenhouse Portfolio Client Medrobotics Receives FDA Market Clearance 2Pittsburgh Life Sciences Greenhouse Portfolio Client Medrobotics Receives FDA Market Clearance 3Isis Reports Financial Results And Highlights For Second Quarter 2015 2Isis Reports Financial Results And Highlights For Second Quarter 2015 3Isis Reports Financial Results And Highlights For Second Quarter 2015 4Isis Reports Financial Results And Highlights For Second Quarter 2015 5Isis Reports Financial Results And Highlights For Second Quarter 2015 6Isis Reports Financial Results And Highlights For Second Quarter 2015 7Isis Reports Financial Results And Highlights For Second Quarter 2015 8Isis Reports Financial Results And Highlights For Second Quarter 2015 9Isis Reports Financial Results And Highlights For Second Quarter 2015 10Isis Reports Financial Results And Highlights For Second Quarter 2015 11Isis Reports Financial Results And Highlights For Second Quarter 2015 12Isis Reports Financial Results And Highlights For Second Quarter 2015 13Isis Reports Financial Results And Highlights For Second Quarter 2015 14Isis Reports Financial Results And Highlights For Second Quarter 2015 15Isis Reports Financial Results And Highlights For Second Quarter 2015 16
Microforceps: Spaid Pic Forceps...
End-gripping forceps with small, concentric rings on each tip. For general purpose membrane grasping, particularly thin membranes, or grasping membranes adherent to the retinal surface....
... design and developmerit of systems for the ... is pleased to present its latest system ... in one compact system. The D.O.R.C. VFI/VFE ... such as silicone oil, with viscosities of ...
... System provides the bright, white illumination ... remarkable difference: HEXON utilizes a metal ... source of high quality illumination. This ... consistency which is well suited for ...
Medicine Products: