Navigation Links
Ovarian function and fertility preserved in women with severe systemic lupus erythematosus
Date:6/12/2008

Paris, France, Thursday 12 June 2008: Ovarian function can be preserved and disease activity controlled in women with severe systemic lupus erythematosus (SLE) when treated with a 6-month course of cyclophosphamide (CYC), a chemotherapy drug, followed by the immunosuppressant mycophenolate mofetil (MMF), according to a new study presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.

SLE, a complex and unpredictable autoimmune disease, is characterised by chronic inflammation and damage of body tissues, including the heart, lungs, kidneys, joints, and/or nervous system. It is most common in women and, although long-term survival has dramatically improved over time with better diagnosis and treatment options, one of the challenges in managing the disease is to minimise the side-effects of treatments such as the disruption of ovarian function and risks to fertility. Pulsed intravenous CYC, a chemotherapeutic agent, is a standard therapy for SLE but may also be associated with ovarian failure in addition to other adverse effects.

Dr Katerina Laskari, the presenting author of the study, led by Professor Athanasios G Tzioufas in the Department of Pathophysiology of the National and Kapodistrian University of Athens, said: "Although the prognosis for people with SLE has considerably improved over the years, a patient's quality of life can all too often be seriously impaired by the toxicity of many commonly-used treatments. Preserving ovarian function is a very important consideration in treating women with SLE of child-bearing age, who are already burdened by the difficult nature and impact of the disease itself."

In this retrospective evaluation of 61 postmenopausal women with SLE treated for lupus nephritis (n=58), autoimmune hemolytic anemia (n=1) and central nervous system involvement (n=2), 39 patients received prolonged treatment with 1g/m2 intravenous (IV) CYC pulses (group A)
'/>"/>

Contact: Rory Berrie / Camilla Dormer
eularpressoffice@uk.cohnwolfe.com
44-077-892-70392
European League Against Rheumatism
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A Knock-Out Match: Kelly Ripa and Molly Sims Team Up to Fight Ovarian Cancer
2. Coveting the Latest Clutch? Bid on a Bag and Help Fight Ovarian Cancer
3. Seattle-Based Marsha Rivkin Center for Ovarian Cancer Research Appoints Nancy Sclater, Executive Director
4. Stored Ovarian Tissue Needs Testing Before Re-Implantation
5. Cancer could return unless stored ovarian tissue undergoes adequate testing before re-implantation
6. Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
7. FASgen Diagnostic Tests Identify Ovarian Cancer Progression and Apoptosis
8. Specialized Care for Ovarian Cancer Improves Outcomes
9. Recurrent low-grade carcinoma of the ovary less responsive to chemo than more common ovarian cancers
10. Advanced-stage ovarian cancer patients with BRCA live longer, may respond better to treatment
11. Gleevec May Disrupt Ovarian Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014 During the Western United States’ ... runs dangerously low, Southern Oregon’s water is proving resistant ... the lowest mountain snow pack on record in 2014, ... early autumn.* That was the observation of journalist-hikers Art ... “Hiking Southern Oregon,” during an interview with water advocate ...
(Date:10/22/2014)... October 22, 2014 Healthcare professionals ... their continuing education at home or on-the-go via ... to 20 brand new, premium Seminar-on-Demand CE courses. ... of over 2,000 hours of CE ... their educational experience. With such a diverse library, ...
(Date:10/22/2014)... 22, 2014 Although there are only 24 hours ... many people who have trouble finding time within their busy schedules ... for long periods of time to get in shape. Here are ... on the go. , Change Up Your Commute , Consider ... to add some exercise into your daily routine. If you must ...
(Date:10/22/2014)... October 22, 2014 Richard Carlson, Managing ... industry leader with over 25 years experience. Mr. ... in the areas related to EDI, B2B Commerce, RFID ... an Editorial Advisory Board member for Pharmaceutical Commerce Magazine ... Blue Fin Group is a management and technology consulting ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... length may be showing a genetic propensity for obesity as ... have been linked to increased body fat, but the same ... muscle, the researchers said. At 1 year, kids with ... and 3, however, these genes were linked to excessive weight ...
Breaking Medicine News(10 mins):Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2
... LAKE CITY University of Utah researchers have developed an ... phones or sending text messages while driving. , The university ... to a private company that hopes to see it ... less than $50 per key plus a yet-undetermined monthly service ...
... Dec. 10 PADRES Contra El Cancer, an,organization dedicated ... cancer and their families, will host its Annual Holiday ... 2008. , Children ... playing,and sledding amongst 40 tons of snow while enjoying ...
... City , , ATLANTIC CITY, N.J., Dec. ... been wounded in the Iraq conflict and recuperating at Walter Reed Army ... to Harrah,s Resorts in Atlantic City. , , ... , from war injuries and wishing for the chance to ...
... Medical Systems (NYSE: VAR ) announced today that it ... the close of regular trading on Thursday, January 29, 2009. ... all interested parties at 2:00 p.m. PT. , ... accessed on January 29, 2009. The news release and information on ...
... Dec. 10 Basic government services are not being provided ... and other communicable diseases are rampant. Staggering inflation and unemployment ... that 300,000 people remain at risk of cholera, which is ... lack of functioning sanitation services. To date, the outbreak has ...
... wait longer for ER treatment, elective procedures, study says ... be a shortage of 1,300 general surgeons in the ... shortage could increase to 6,000 by 2050, a new ... perform lifesaving operations on critically injured or seriously ill ...
Cached Medicine News:Health News:Car key jams teen drivers' cell phones 2Health News:Car key jams teen drivers' cell phones 3Health News:Car key jams teen drivers' cell phones 4Health News:PADRES Contra El Cancer to Host its 10th Annual Posada Holiday Celebration for Children with Cancer 2Health News:Wounded Warriors to be Holiday Guests of Harrah's Entertainment 2Health News:Varian Medical Systems Schedules First Quarter FY2009 News Release and Conference Call 2Health News:Varian Medical Systems Schedules First Quarter FY2009 News Release and Conference Call 3Health News:U.S. May Soon Face Shortage of General Surgeons 2
(Date:10/22/2014)... Calif. , Oct. 22, 2014  AcelRx ... announced that results from the  IAP310 study have ... Medicine (RAPM), a peer-reviewed journal with broad, ... 3 trial evaluating the safety and efficacy of ... tablet system (SSTS), for the treatment of post-operative ...
(Date:10/20/2014)... , 20 de octubre de 2014 /PRNewswire/ ... el campo de la pulmonología intervencional, anunció hoy ... RENEW, casi 3 meses antes de lo programado. El ... exención de dispositivo de investigación (IDE) aprobada por ... el sistema de espiral de reducción de volumen ...
(Date:10/20/2014)... SAN DIEGO , Oct. 20, 2014   BioNano ... the Irys system: the ability to collect human data at ... on a single chip.  This new capability was established and ... for the Irys TM System and will ... next two months. BioNano will be showcasing this advancement at ...
Breaking Medicine Technology:AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3BioNano Genomics Announces One Human : One Chip : One Day 2BioNano Genomics Announces One Human : One Chip : One Day 3
... 26, 2012 Interventional Spine, Inc. today announced ... Body Fusion Device. (Logo: ... Access Instrument, which provides unparalleled percutaneous access to ... an integral part of Interventional Spine,s revolutionary PerX360 ...
... VIEW, Calif., Jan. 25, 2012  IRIDEX Corporation (Nasdaq: ... clinical study evaluating the use of IRIDEX, MicroPulse ... effectiveness with patients diagnosed with central serous chorioretinopathy ... is superior to anti-VEGF injections for CSC, also ...
Cached Medicine Technology:Interventional Spine, Inc. Announces FDA Clearance of its Opticage™ Expandable Interbody for Treatment of Degenerative Disc Disease 2IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 2IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 3