Navigation Links
Ovarian cancers detected early may be less aggressive, questioning effectiveness of screening
Date:3/24/2009

DURHAM, N.C. -- The biology of ovarian cancers discovered at an early stage may render them slower growing and less likely to spread than more aggressive cancers, which typically are discovered in an advanced stage, according to a study led by investigators in the Duke Comprehensive Cancer Center. This finding has implications for the question of whether screening for ovarian cancer could save lives.

"Our study showed that the ovarian cancers currently detected at an early stage have gene expression profiles that correlate with favorable outcome, rather than being representative of the entire spectrum of disease aggressiveness," said Andrew Berchuck, M.D., a gynecologic oncologist at Duke and lead investigator on this study. "This highlights the potential challenges of developing a screening test for this disease, because earlier detection of aggressive cases is essential if screening is to reduce ovarian cancer deaths."

The results of this study and the implications for screening as an approach to decreasing mortality parallel the challenges seen in lung cancer and prostate cancer. In those cancers, while screening approaches based on radiological imaging and/or blood markers detect cancers, it remains unclear whether cancer-related deaths are prevented because screening preferentially detects more benign cancers that are much less likely to be fatal, Berchuck said.

"While these results could be seen as discouraging, it must be remembered that this information is an important piece of the ovarian cancer puzzle, and data like these that increase our understanding of the disease hopefully will eventually lead to breakthroughs in prevention, early detection and treatment of this deadly disease," Berchuck said.

Although there is currently no approved ovarian cancer screening test for the general population, the CA125 blood test and transvaginal ultrasound imaging currently are being evaluated in clinical trials.

The
'/>"/>

Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

1

GOOD

Page: 1 2

Related medicine news :

1. Morphotek(R), Inc. and Eisai Corporation of North America Announce FDA Special Protocol Assessment (SPA) for Phase III Trial Evaluating Farletuzumab in Relapsed Ovarian Cancer
2. Combo Screening Doesnt Spot Early Ovarian Cancer
3. Early Detection Remains Key in Updated NCCN Guidelines for Ovarian Cancer
4. Combo of Tests Might Spot Ovarian Cancer Early
5. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
6. Fertility Drugs Do Not Increase Ovarian Cancer Risk
7. Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
8. Fujirebio Diagnostics and Abbott Agree To Develop New Ovarian Cancer Test for Abbotts Architect(R) Analyzers
9. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
10. Treadmill Desks Combat Obesity Linked to Higher Rates of Ovarian Cancer
11. Obesity Linked to Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... May 19, 2013 Beginning Wednesday, May 29 ... Blood Center (RRVBC) will feature “Hot Dog Wednesdays" and Ice ... RRVBC will provide hot dogs and all the fixin's to ... each day throughout the summer. “Donors are our lifeline. The ... stable and adequate blood supply. This is a small ...
(Date:5/19/2013)... HealthEconomics.Com , the global leader ... unveil a new and exciting service: HE-Xpo: a media-rich, ... array of real-time communication tools to expand their digital ... , HE-Xpo is powered by OnStream Media’s ... feel of being at a physical trade show, all ...
(Date:5/19/2013)... The Da Vinci robot lawyers at ... the nation’s first trial involving a Da Vinci surgical ... Superior Court, was filed by the widow of a ... in a robot-assisted prostate removal, according to a report ... surgery lawsuit alleges those complication’s hastened his death. ...
(Date:5/18/2013)... 2013 Daily Gossip issued a press release ... on their page. John Colston, Daily Gossip’s spokesperson, told the ... revolutionizing 14-Day Rapid Fat Loss Plan . , ... are healthy at a time when nutritionists and fat loss ... products. , The diet is based on the ...
(Date:5/18/2013)... American Gastroenterological Association (AGA) Research Foundation is pleased ... honorees are outstanding young gastroenterologists working toward independent ... with this award, their research time will be ... future of our field. AGA is committed to ... for promising research developments and new therapies," said ...
Breaking Medicine News(10 mins):Health News:Hot Dog Wednesdays and Ice Cold Slushies Return to Rock River Valley Blood Center for the Summer 2Health News:HealthEconomics.Com Announces HE-Xpo, a New Virtual Trade Show Devoted to Healthcare Value and Market Access 2Health News:HealthEconomics.Com Announces HE-Xpo, a New Virtual Trade Show Devoted to Healthcare Value and Market Access 3Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 2Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 3Health News:Da Vinci Surgical Robot Lawyers at Wright & Schulte LLC Note Recent Developments in Da Vinci Robot Lawsuit Trial 4Health News:AGA Research Foundation Research Scholar Awards advance the work of promising gastroenterologists 2
... genetic malfunction that causes DNA instability in people with ... high risk for squamous cell carcinomas linked to human ... of print by Oncogene . , Researchers led ... of a cell signaling pathway for the FA (Fanconi ...
... climax, Sharing Miracles, a 30-minute public affairs television program ... feature Super Bowl-winning running back and likely Hall-of-Famer Jerome Bettis. ... across the United States. , , ... -- was 14 years old when he was first diagnosed with ...
... 3 CYNACON/OCuSOFT(R) a broad based,supplier of ophthalmic ... findings from a recent study(1). OCuSOFT(R) Lid Scrub(TM) ... effectively eradicate Demodex,mites. Significantly, NO other eyelid cleanser ... (Photo: ...
... 3 The Coalition for Pulmonary Fibrosis (CPF) today announced ... patients and families fighting pulmonary fibrosis (PF), a devastating and ... and affecting more than 128,000 Americans. Prevalence and incidence ... and PF claims 40,000 lives each year - the same ...
... to capital becoming more restricted accompanied by a significant decline ... growing charity care, many hospitals and health systems are extremely ... In the wake of the current economic crisis, here are ... care delivery in 2009, as predicted by the Noblis Center ...
... per cent of men who took degarelix for prostate cancer ... days after they started treatment, according to a paper in ... , They also experienced much greater falls in ... than men taking leuprolide. , Researchers from Canada, the ...
Cached Medicine News:Health News:Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer 2Health News:Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer 3Health News:Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer 4Health News:'Sharing Miracles' Television Program to Feature Super Bowl-Winning Running Back Jerome Bettis 2Health News:'Sharing Miracles' Television Program to Feature Super Bowl-Winning Running Back Jerome Bettis 3Health News:'Sharing Miracles' Television Program to Feature Super Bowl-Winning Running Back Jerome Bettis 4Health News:'Sharing Miracles' Television Program to Feature Super Bowl-Winning Running Back Jerome Bettis 5Health News:'Sharing Miracles' Television Program to Feature Super Bowl-Winning Running Back Jerome Bettis 6Health News:'Sharing Miracles' Television Program to Feature Super Bowl-Winning Running Back Jerome Bettis 7Health News:OCuSOFT(R) Lid Scrub(TM) PLUS Proven to Kill Demodex Mites 2Health News:CPF Updates Patient Education Materials to Meet Growing Demand for Pulmonary Fibrosis Information 2Health News:CPF Updates Patient Education Materials to Meet Growing Demand for Pulmonary Fibrosis Information 3Health News:CPF Updates Patient Education Materials to Meet Growing Demand for Pulmonary Fibrosis Information 4Health News:The Noblis Center for Health Innovation Forecasts 2009 Trends In Provider Health Care Delivery 2Health News:The Noblis Center for Health Innovation Forecasts 2009 Trends In Provider Health Care Delivery 3Health News:Prostate cancer drug reduces testosterone levels in as little as 3 days 2Health News:Prostate cancer drug reduces testosterone levels in as little as 3 days 3
(Date:5/16/2013)... May 16, 2013  PTC Therapeutics, Inc., today announced ... S-1 with the U.S. Securities and Exchange Commission ("SEC") ... common stock. The number of shares to be offered ... been determined. (Logo:  http://photos.prnewswire.com/prnh/20010919/PTCLOGO ) ... as joint book-running managers for the offering. Cowen and ...
(Date:5/16/2013)... , May 16, 2013  HeartWare International, Inc. (NASDAQ: ... of less invasive, miniaturized circulatory support technologies that are revolutionizing ... Doug Godshall is scheduled to present ... EDT on Monday, May 20, 2013.  The conference is being ... A live webcast of the Company,s presentation at ...
(Date:5/16/2013)... 2013 AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX ... commercialization of innovative therapies for the treatment of acute and ... , President and CEO, will present a corporate overview at ... Hotel in New York , NY.  The ... a.m. ET/6:30 a.m. PT. The presentation will be ...
Breaking Medicine Technology:PTC Therapeutics, Inc. Files Registration Statement for Proposed Initial Public Offering 2HeartWare Presentation At The 2013 UBS Global Healthcare Conference To Be Webcast 2AcelRx Pharmaceuticals to Present at the UBS Global Healthcare Conference 2AcelRx Pharmaceuticals to Present at the UBS Global Healthcare Conference 3
... Carefx Corp. , a leading provider of interoperable workflow solutions, ... and further develop the Cleveland Clinic business intelligence (BI) dashboards that are ... , , ... of its BI dashboards currently being used to manage business and clinical ...
... May 18 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ... a leading fully,integrated pharmaceutical company producing over-the-counter drugs in ... results,for the first quarter of 2010. Management is working diligently ... , , First Quarter 2010 Financial Highlights, ...
Cached Medicine Technology:Carefx to Collaborate with the Cleveland Clinic to Commercialize CCF Business Intelligence Solution 2Carefx to Collaborate with the Cleveland Clinic to Commercialize CCF Business Intelligence Solution 3China Sky One Medical Announces First Quarter 2010 Results 2China Sky One Medical Announces First Quarter 2010 Results 3China Sky One Medical Announces First Quarter 2010 Results 4China Sky One Medical Announces First Quarter 2010 Results 5China Sky One Medical Announces First Quarter 2010 Results 6China Sky One Medical Announces First Quarter 2010 Results 7China Sky One Medical Announces First Quarter 2010 Results 8China Sky One Medical Announces First Quarter 2010 Results 9China Sky One Medical Announces First Quarter 2010 Results 10China Sky One Medical Announces First Quarter 2010 Results 11China Sky One Medical Announces First Quarter 2010 Results 12China Sky One Medical Announces First Quarter 2010 Results 13China Sky One Medical Announces First Quarter 2010 Results 14
Bravo Tubing/Filter Supplies (Ten tubing sets, ten filters)...
... esophhageal sphincter (LES) can be ... separate manometry system. pH catheters ... accessory kit and Digitrapper pH ... the LES. The kit and ...
Buffer solution is needed to calibrate pH catheters. The specific chloride ion concentration in the Medtronic buffers is required for proper function of your Medtronic pH measurement system. Buffer s...
The WaveMax is one of the most flexible stainless steel stents due to its unique wave design and has the lowest effective profile, accommodating a 6F sheath up to 7 mm....
Medicine Products: