Navigation Links
Ovarian cancer stem cell study puts targeted therapies within reach
Date:1/6/2013

Researchers at Yale School of Medicine have identified a key link between stem cell factors that fuel ovarian cancer's growth and patient prognosis. The study, which paves the way for developing novel targeted ovarian cancer therapies, is published online in the current issue of Cell Cycle.

Lead author Yingqun Huang, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences, and her colleagues have demonstrated a connection between two concepts that are revolutionizing the way cancer is treated.

First, the "cancer stem cell" idea suggests that at the heart of every tumor there is a small subset of difficult-to-identify tumor cells that fuel the growth of the bulk of the tumor. This concept predicts that ordinary therapies typically kill the bulk of tumor cells while leaving a rich environment for continued growth of the stem cell tumor population.

The second concept, dubbed "seed and soil," defines a critical role for the tumor cells' "microenvironment," which is the special environment required for cancer cell growth and spread.

"Both concepts have particular relevance for the treatment of adult solid tumors such as ovarian cancer, which has been notoriously difficult to diagnose and treat," said co-author Nita J. Maihle, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences and a member of Yale Cancer Center. "Ovarian cancer patients are plagued by recurrences of tumor cells that are resistant to chemotherapy, ultimately leading to uncontrolled cancer growth and death."

In this study, Huang and her colleagues were able to define a molecular basis for the interplay between these two concepts in ovarian cancer. They did this by using sophisticated gene sequencing methods to demonstrate a regulatory link between the stem cell factor Lin28 and the signaling molecule bone morphogenic protein 4 (BMP4).

"These results are supported by the latest molecular ovarian cancer prognosis data, which also suggest an active role for the tumor microenvironment in ovarian carcinogenesis," said Huang and Maihle. "Together these studies reveal new targets for the development of cancer therapies."


'/>"/>

Contact: Karen N. Peart
karen.peart@hotmail.com
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
2. U.S. Panel Rejects Ovarian Cancer Screening
3. UC Irvine study finds racial, economic disparities in ovarian cancer care, survival
4. Internationally known expert in ovarian cancer to be honored at the ASCO Annual Meeting
5. The prevention of hereditary breast and ovarian cancer by PGD is feasible
6. Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstream
7. Ovarian Transplants May Preserve Fertility in Young Cancer Survivors
8. Benefit of PET and PET/CT in ovarian cancer is not proven
9. Mechanisms of acquired chemoresistance in ovarian cancer identified
10. U.S. Panel Rejects Ovarian Cancer Screens for Low-Risk Women
11. Simple ovarian cancer symptom survey that checks for 6 warning signs may improve early detection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... “The Trainer”: an ... published author, Scotty, a fiction writer with an active imagination and an enthusiasm for ... book follows the tale of Wild Bill Hart, who sat looking at the thirty-three ...
(Date:3/22/2017)... Australia (PRWEB) , ... March 23, 2017 , ... Death ... a nurse by profession, author Joy Nugent was inspired to write the book titled ... came from her inward desire to make sense of what she was experiencing at ...
(Date:3/22/2017)... ... March 22, 2017 , ... Sam ... insurance assistance, financial planning, and related services to residents of the region, is ... awareness of threatened species and wild lands. , Endangered Species International is committed ...
(Date:3/22/2017)... Angeles, California (PRWEB) , ... March 22, 2017 , ... ... signed British boxing champ Ashley Theophane as a new Brand Ambassador. Theophane, who trained ... British light welterweight title in 2011. He has racked up an impressive number of ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... the nation’s leading digital and print media enterprise focused on cancer patients, cancer ... content, has released a special 12-part educational video series, “No Ifs, Ands, or ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... LINCOLN, Mass. , March 22, 2017 /PRNewswire/ ... applying mechanistic modeling to drug research and development, ... QSP Day 2017.  QSP Day 2017 is a ... with the quantitative systems pharmacology (QSP) community. The ... mathematical modeling is de-risking and accelerating drug research ...
(Date:3/22/2017)... , March 22, 2017 Hologic, Inc. (Nasdaq: ... completed the acquisition of Cynosure, Inc., a leader in ... in cash. "We are pleased to complete ... with Michael Davin and the entire Cynosure ... rapidly growing medical aesthetics market," said Steve MacMillan ...
(Date:3/22/2017)... 22, 2017 FinancialBuzz.com News Commentary ... rapidly due to the significant development and innovation in ... Market Research, the global electrophysiology market was worth $3.42 ... billion by 2022, with a GAGR of 13.4%. Electrophysiology ... diagnose abnormal heartbeats or arrhythmia. The report indicates that ...
Breaking Medicine Technology: