Navigation Links
Ovarian cancer screening not catching early disease
Date:4/1/2009

BIRMINGHAM, Ala. The only available screening tests for ovarian cancer fail to catch early signs of the disease and often result in unnecessary surgery, said researchers at the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center.

The new study looked at a screening regimen that combines ultrasound and a blood test for CA-125, a marker for women's cancer.

Results showed the combo screening caught 70 percent of the ovarian cancers in their late stages, when effective treatment options are limited.

Knowing this screening limitation means the search has intensified for a better way to detect ovarian cancer, often called the "silent killer," said Edward Partridge, M.D., director of the UAB Comprehensive Cancer Center and the lead study author.

"We still have some comparison data to review, but right now it looks like the positive predictive value of these tests is pretty low," Partridge said.

The study puts the positive predictive value for both tests at around 1.6 percent per 100 positive screening results, a remarkably low positivity rate that led to many false positives, he said. False positives are erroneous signals of cancer where there is none.

The UAB results are published April 1 in the journal Obstetrics & Genecology.

One alarming trend noted in the study is how often transvaginal ultrasound led to a high rate of unnecessary removal of the ovaries, which means no cancer was detected in these organs post-surgery.

"This data suggests that we need a better screening tool. We need a test that is more sensitive and more specific so we find the cancer earlier and we catch the biological markers that give us stronger clues," Partridge said.

The study was part of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO trial) and included more than 72,000 women aged 55 to 74.

The PLCO results coincide with a British study published March 10 online in The Lancet Oncology that found combo screening for ovarian cancer was extremely successful in finding early stage cancers. But that still doesn't mean the screens led to a reduction in the ovarian cancer death rate, reported the British study authors from the University College London.

Ovarian cancer ranks as the fifth leading cause of female cancer death, and it is diagnosed primarily in women aged 55 and older. Early stages of the cancer cause somewhat vague symptoms and many malignancies go undetected until other organs and tissues are involved.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Doctors at Henry Ford Health System Treat Ovarian, Prostate, Lung, and Other Forms of Cancer Using Novalis Tx(TM) Platform for Image-Guided Radiosurgery
2. Catching Ovarian Cancer Early May Miss Aggressive Tumors
3. Ovarian cancers detected early may be less aggressive, questioning effectiveness of screening
4. Morphotek(R), Inc. and Eisai Corporation of North America Announce FDA Special Protocol Assessment (SPA) for Phase III Trial Evaluating Farletuzumab in Relapsed Ovarian Cancer
5. Combo Screening Doesnt Spot Early Ovarian Cancer
6. Early Detection Remains Key in Updated NCCN Guidelines for Ovarian Cancer
7. Combo of Tests Might Spot Ovarian Cancer Early
8. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
9. Fertility Drugs Do Not Increase Ovarian Cancer Risk
10. Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
11. Fujirebio Diagnostics and Abbott Agree To Develop New Ovarian Cancer Test for Abbotts Architect(R) Analyzers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... Livermore, California (PRWEB) , ... December 02, 2016 ... ... business professionals, proudly announces the launch of its 60-day free trial program for ... round trip shipping make the offer a truly hassle free experience. , FlexiSpot’s ...
(Date:12/2/2016)... , ... December 02, 2016 , ... With the number ... rehabilitation of an injury, patients must find the one that works for them. When ... he created a machine that worked and decided to share it with others. , ...
(Date:12/2/2016)... ... ... Mediaplanet is proud to announce the launch of its ... therapeutic technologies, and revolutionized nutrition that are helping patients and physicians manage their ... the last 3 decades,” says Dr. Valentine Fuster, a world-renowned cardiologist. “This is ...
(Date:12/2/2016)... ... ... Sourced from the Isbre Springs beneath the 5,000 year old Hardanger Glacier ... just 6 ppm TDS (Total Dissolved Solids) in addition to its excellent taste profile ... ShopRite and FoodTown stores in NJ and received rave comments from consumers. , Thanks ...
(Date:12/2/2016)... ... 02, 2016 , ... Clarify Health Solutions, Inc., the leading ... in an initial round of funding. The round was led by experienced investors ... receive far better care through the application of the best technologies from other ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016 CVS Health Corporation (NYSE: ... in New York City on Thursday, December 15, 2016, beginning at 8:00 a.m. ... will provide an in-depth review of the company,s strategies ... company will also discuss 2017 earnings guidance during the ... the event will be broadcast simultaneously on the Investor ...
(Date:12/2/2016)... 2016 Lianluo Smart Limited (Nasdaq: ... which develops, markets and sells medical devices and ... and international markets, recently attended the ... New Progress Forum, co-hosted by the Institute of ... , Guangdong Provincial People,s Hospital and Cardiology Department ...
(Date:12/2/2016)... -- On Thursday, the NASDAQ Composite ended the ... Average edged 0.36% higher, to finish at 19,191.93; and the ... based as six out of nine sectors ended the day ... following Services equities: Myriad Genetics Inc. (NASDAQ: MYGN ... Holdings Inc. (NASDAQ: INCR ), and La Quinta ...
Breaking Medicine Technology: