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Ovarian cancer cells bully their way through tissue
Date:6/14/2011

BOSTON, Mass. (June 14, 2011) A team led by Joan Brugge, the Louise Foote Pfeiffer Professor of Cell Biology at Harvard Medical School, recently shed light on how ovarian cancer spreads. In a paper published in the July edition of the journal Cancer Discovery, the newest journal of the American Association for Cancer Research, Brugge and colleagues found that ovarian cancer cells act like bullies, using brute force to plow their way through tissue and colonize additional organs.

"This is the first time that mechanical force has been implicated in the spread of ovarian cancer," says Brugge, who is also chair of the Department of Cell Biology. "While this research is still preliminary, we are building a foundation for the development of treatments based on a robust understanding of the disease."

According to the National Cancer Institute, ovarian cancer accounts for about three percent of all cancers among women in the United States. It caused nearly 14,000 deaths in 2010 alone.

The ovaries and many other organs, such as the liver, stomach and intestines, are located in an anatomical space called the peritoneal cavity. The lining of this cavity is called the peritoneum, and its top layer is called the mesothelium. After an ovarian tumor develops, clusters of cancer cells are released into the peritoneal cavity. Each cluster floats around until it encounters the lining of the cavity. It attaches to the lining, spreads out and launches an invasion into the mesothelium. Brugge's team determined how ovarian cancer cells get through the mesothelium to colonize organs on the other side.

When researchers placed ovarian cancer cells and mesothelial cells together in a dish, the cancer cells formed a hole in the mesothelial layer, mirroring behavior that would occur in the body as an invasion proceeds. The team interfered with molecular components of the cancer cells one by one and used time-lapse microscopy to watch the re
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Contact: David Cameron
communications@hms.harvard.edu
617-432-0442
Harvard Medical School
Source:Eurekalert

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