Navigation Links
Ovarian Cancer Breakthrough Heralds New Era of Treatment
Date:6/10/2009

Scientists identify cause of deadly tumors and predict life-saving developments could follow

WEDNESDAY, June 10 (HealthDay News) -- Canadian researchers have zeroed in on the cause of a deadly type of ovarian cancer, a finding that could lead to successful treatment of the rare granulosa cell tumors.

The culprit is a single mutation out of 3 billion nucleotide pairs that make up the genetic code of the tumor. The mutation is present in every granulosa cell tumor, a rare and often untreatable form of ovarian cancer that affects about 5 percent of ovarian cancer patients, according to a study that appears in the June 10 online issue of the New England Journal of Medicine.

The discovery, made using state-of-the-art gene-sequencing technologies, may mark the beginning of a new era of cancer genomics, in which the complete genetic sequence of cancers and the mutations that cause them can be identified, researchers said.

For women with granulosa cell tumors, the precise identification of the mutation may help in developing new, badly needed treatments.

"This is really a two-fold discovery," said lead study author Dr. David Hunstman, a genetic pathologist at the BC Cancer Agency and Vancouver General Hospital and an associate professor at the University of British Columbia.

"It clearly shows the power of the new generation of DNA sequencing technologies to impact clinical medicine, and for those of us in the area of ovarian cancer research and care, by identifying the singular mutation that causes granulosa cell tumors, we can now more easily identify them and develop new ways to treat them," he added in a university news release.

In the study, researchers decoded four granulosa cell tumors using "next generation" sequencing machines that decode billions of nucleotides at rapid speed and new computer techniques to quickly assemble the data.

While most types of cancer, including ovarian cancers, have a broad range of genetic abnormalities, researchers found a mutation in a single nucleotide in the FOXL2 gene in every sample.

The research team further validated the findings by examining additional tumor samples from across Canada and around the world.

In the past, analyzing the sequence of a tumor was a laborious process, and most studies could only look at one or only a few of the 20,000 genes in the human genome. The new sequencing technologies allow scientists to look at all at once.

"This task would have been unfathomable in terms of both cost and complexity even two years ago," said Dr. Marco Marra, director of the BC Cancer Agency's Genome Sciences Center.

Researchers chose granulosa cell tumors because, unlike other cancers, they are "clinically homogenous," Huntsman said.

"This cancer is unique," said Dr. Dianne Miller, a gynecologic oncologist at BC Cancer Agency and Vancouver General Hospital. "For patients with this tumor type, it means they should all have the same response to the same treatment. And now that we have this pathway, we can look for existing cancer drugs that might work on this particular gene mutation to make the cancer disappear."

Researchers plan to study other rare tumor types using a similar method.

More information

The American Cancer Society has more on ovarian cancer.



-- Jennifer Thomas



SOURCE: University of British Columbia, news release, June 10, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cranberry Could Juice Up Ovarian Cancer Treatment
2. New Ovarian Cancer Drug Trial Under Way
3. Pelvic Exams Can Help Spot Ovarian Cancer
4. Study fuels debate over whether exercise and body size influence ovarian cancer risk
5. Experimental drug boosts survival in recurrent ovarian cancer
6. New Ovarian Cancer Biomarker Research Act Introduced
7. Common Early-Warning Symptoms of Ovarian Cancer Identified in CDC/Thomson Healthcare Study
8. More Fiber, Less Fat Help Prevent Ovarian Cancer
9. Media availability: low-fat dietary pattern may lower risk of ovarian cancer
10. The Silent Killer, Ovarian Cancer on Your Cancer Today (TM)
11. Society of Gynecologic Oncologists Provides Guidelines for Offering Genetic Risk Assessment to Women With a Personal or Family History of Breast, Ovarian, Uterine or Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ovarian Cancer Breakthrough Heralds New Era of Treatment 
(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/27/2016)... ... 27, 2016 , ... A revolution is underway. Brooklyn-based ... experience for the millions of people who require these medical transport services annually. ... through the use of technology. Now, SmartEMS has put forth an industry-changing app ...
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many ... the beholder, according to experts who offered insights and commentary in the current issue ... the full issue, click here . , For the American Society of Clinical ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
Breaking Medicine Technology: