Navigation Links
Ovarian Cancer Breakthrough Heralds New Era of Treatment

Scientists identify cause of deadly tumors and predict life-saving developments could follow

WEDNESDAY, June 10 (HealthDay News) -- Canadian researchers have zeroed in on the cause of a deadly type of ovarian cancer, a finding that could lead to successful treatment of the rare granulosa cell tumors.

The culprit is a single mutation out of 3 billion nucleotide pairs that make up the genetic code of the tumor. The mutation is present in every granulosa cell tumor, a rare and often untreatable form of ovarian cancer that affects about 5 percent of ovarian cancer patients, according to a study that appears in the June 10 online issue of the New England Journal of Medicine.

The discovery, made using state-of-the-art gene-sequencing technologies, may mark the beginning of a new era of cancer genomics, in which the complete genetic sequence of cancers and the mutations that cause them can be identified, researchers said.

For women with granulosa cell tumors, the precise identification of the mutation may help in developing new, badly needed treatments.

"This is really a two-fold discovery," said lead study author Dr. David Hunstman, a genetic pathologist at the BC Cancer Agency and Vancouver General Hospital and an associate professor at the University of British Columbia.

"It clearly shows the power of the new generation of DNA sequencing technologies to impact clinical medicine, and for those of us in the area of ovarian cancer research and care, by identifying the singular mutation that causes granulosa cell tumors, we can now more easily identify them and develop new ways to treat them," he added in a university news release.

In the study, researchers decoded four granulosa cell tumors using "next generation" sequencing machines that decode billions of nucleotides at rapid speed and new computer techniques to quickly assemble the data.

While most types of cancer, including ovarian cancers, have a broad range of genetic abnormalities, researchers found a mutation in a single nucleotide in the FOXL2 gene in every sample.

The research team further validated the findings by examining additional tumor samples from across Canada and around the world.

In the past, analyzing the sequence of a tumor was a laborious process, and most studies could only look at one or only a few of the 20,000 genes in the human genome. The new sequencing technologies allow scientists to look at all at once.

"This task would have been unfathomable in terms of both cost and complexity even two years ago," said Dr. Marco Marra, director of the BC Cancer Agency's Genome Sciences Center.

Researchers chose granulosa cell tumors because, unlike other cancers, they are "clinically homogenous," Huntsman said.

"This cancer is unique," said Dr. Dianne Miller, a gynecologic oncologist at BC Cancer Agency and Vancouver General Hospital. "For patients with this tumor type, it means they should all have the same response to the same treatment. And now that we have this pathway, we can look for existing cancer drugs that might work on this particular gene mutation to make the cancer disappear."

Researchers plan to study other rare tumor types using a similar method.

More information

The American Cancer Society has more on ovarian cancer.

-- Jennifer Thomas

SOURCE: University of British Columbia, news release, June 10, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cranberry Could Juice Up Ovarian Cancer Treatment
2. New Ovarian Cancer Drug Trial Under Way
3. Pelvic Exams Can Help Spot Ovarian Cancer
4. Study fuels debate over whether exercise and body size influence ovarian cancer risk
5. Experimental drug boosts survival in recurrent ovarian cancer
6. New Ovarian Cancer Biomarker Research Act Introduced
7. Common Early-Warning Symptoms of Ovarian Cancer Identified in CDC/Thomson Healthcare Study
8. More Fiber, Less Fat Help Prevent Ovarian Cancer
9. Media availability: low-fat dietary pattern may lower risk of ovarian cancer
10. The Silent Killer, Ovarian Cancer on Your Cancer Today (TM)
11. Society of Gynecologic Oncologists Provides Guidelines for Offering Genetic Risk Assessment to Women With a Personal or Family History of Breast, Ovarian, Uterine or Colorectal Cancer
Post Your Comments:
Related Image:
Ovarian Cancer Breakthrough Heralds New Era of Treatment 
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: ) , ... , TwinLink™ - the first dual communication ...
Breaking Medicine Technology: