Navigation Links
Outwitting immunity to treat disease: Start-up raises 37 millions dollars
Date:5/5/2014

in PNAS and received an enormous amount of attention.

"The technology delivers proteins, be they autoimmune antigens or protein drugs, in a manner that re-trains the immune system to accept them as the body's own," explains Hubbell "We are delighted that leading biotech venture funds have recognized the value of our approach, providing the necessary financial means to move forward."

Anokion's mission is to commercialize this discovery so that it can move out of the lab and into use as a treatment for disease. For now, the researchers are concentrating on a specific kind of white blood cell, T lymphocytes, that are implicated in many autoimmune and allergic diseases, including multiple sclerosis and type I diabetes.

The technology has a far wider potential, however. Protein drugs are used to treat diseases such as cancer and a number of genetic diseases such as hemophilia. Despite their effectiveness in treating these diseases, the body frequently recognizes these proteins as foreign and mounts an immune response against them, sometimes even after one or a few doses. After this, the body neutralizes the protein drugs that have been developed to heal it.

Using Anokion's technique, the drug could be administered over a much longer period by teaching the immune system to leave it alone. Multiple therapeutic molecules that trigger immune reactions have been withdrawn after clinical trials due to these immunogenicity challenges. The researchers think that many of these could be rehabilitated if the immune response of the T-cells during treatment could be controlled.

Anokion is planning clinical trials for 2017. They will initially test their technology in conjunction with a drug known to trigger strong immune reactions before moving on to autoimmune diseases.


'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers generate immunity against tumor vessel protein
2. Testosterone-regulated genes may affect vaccine-induced immunity
3. Combat the Flu with Immunity Products from Kirkman®
4. Maternal smoking may impair infant immunity, causing a broad range of infections
5. Wiley launches new open access journal: Immunity, Inflammation and Disease
6. Anxiety about relationships may lower immunity, increase vulnerability to illness
7. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
8. From herd immunity and complacency to group panic: How vaccine scares unfold
9. Study unveils new approach to treating brittle bone disease
10. Study points to potential revision of treatment guidelines for bleeding ulcers
11. Vibrating capsule shows promising results in treating chronic constipation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... in cancer patients suffering from malignant spinal cord compression ... of radiation therapy (RT), compared to patients who receive ... according to research presented today at the American Society ... Malignant spinal cord compression (MSCC) is a complication of ... a tumor,s secondary deposit presses on the spinal cord ...
(Date:9/16/2014)... Umpires and judges are the unwitting focus of some ... and gymnasts to improve their performance in competition, thanks ... researcher. , Dr Daniel Greenwood, from QUT,s Institute of ... Academy of Sport Centre of Excellence for Applied Sport ... in sports such as cricket, long jump, triple jump ...
(Date:9/16/2014)... Beginning October 1st 2014, Dallas’ Park Cities Pet ... clients who book a recurring visit schedule, and thus receive ... Most recurring visit clients are ones that book ... include clients whose unique work schedules or lifestyles simply require ... basis. The newly introduced 15-minute visit length will only ...
(Date:9/16/2014)... York (PRWEB) September 16, 2014 Transparency ... states that the global facial care market is expected ... 2019. The report, titled ‘Facial Care Market (By Product ... Face Wash, Cleansing Wipes, Serums and Masks and Others ... Size, Share, Growth, Trends and Forecast 2013 – 2019,’ ...
(Date:9/16/2014)... Whatisfinalexpenseinsurance.com has released a new blog post ... seniors. , Finding affordable life insurance for senior citizens ... the insurance market has moved online. The newly released ... use when shopping for life coverage. , Having ... financial security for vulnerable family members. Clients can use ...
Breaking Medicine News(10 mins):Health News:Cancer patients with malignant spinal cord compression have preserved mobility 2Health News:Cancer patients with malignant spinal cord compression have preserved mobility 3Health News:Cancer patients with malignant spinal cord compression have preserved mobility 4Health News:Getting the jump on competitors: QUT study 2Health News:Dallas-based Park Cities Pet Sitter Introduces New 15-Minute Visit for Clients on Recurring Visit Schedules. 2Health News:Dallas-based Park Cities Pet Sitter Introduces New 15-Minute Visit for Clients on Recurring Visit Schedules. 3Health News:Global Facial Care Market Will Report a CAGR of 6.9% between 2013 and 2019: Transparency Market Research 2Health News:Global Facial Care Market Will Report a CAGR of 6.9% between 2013 and 2019: Transparency Market Research 3Health News:Life Insurance for Seniors - Clients Can Find Fast Life Insurance By Comparing Online Quotes! 2
... life expectancy, study finds , TUESDAY, Feb. 23 ... MRI appears to be a cost-effective way to improve ... cancer, U.S. researchers say. , In the new study, ... in Boston, and colleagues used statistical modeling to compare ...
... ... ... ... ...
... stress hormone levels in adolescent boys and girls but ... researchers. Early treatment of depression could help reduce stress ... "This is the first time cortisol reactivity has ... obesity in girls," said Elizabeth J. Susman, the Jean ...
... ... ... , ... , , , , ...
... LOUIS -- The extract from a vegetable that is common ... of events that kills breast cancer cells and prevents them ... Ratna Ray, Ph.D., professor in the department of pathology at ... that the extract from the bitter melon she cooks in ...
... ... ... ... ...
Cached Medicine News:Health News:Mammogram Plus MRI Seems Cost-Effective in High-Risk Women 2Health News:First Coast Service Options (FCSO) Expands Use of Burgess Products 2Health News:First Coast Service Options (FCSO) Expands Use of Burgess Products 3Health News:First Coast Service Options (FCSO) Expands Use of Burgess Products 4Health News:Stress hormone, depression trigger obesity in girls 2Health News:Johnson & Johnson to Participate in RBC Capital Markets' Health Care Conference 2Health News:Bitter melon extract attacks breast cancer cells 2Health News:Kimberly-Clark Announces 10 Percent Dividend Increase 2Health News:Kimberly-Clark Announces 10 Percent Dividend Increase 3
(Date:9/16/2014)... BOSTON , September 16, 2014 ... Fiona Marshall , will give a presentation entitled " ... StaR ®   technology " ... and Development " virtual symposium run by Chemical & Engineering ... symposium is on Wednesday, 24 September 2014; Dr Marshall,s presentation ...
(Date:9/15/2014)... FRANCISCO , Sept. 15, 2014 ... studies presented at the American Society for Radiation ... its Decipher® Prostate Cancer Classifier, a genomic test ... influence treatment decisions and improve patient outcomes for ... These presentations follow a recently published study that ...
(Date:9/15/2014)... DALLAS , Sept. 15, 2014 /PRNewswire-iReach/ -- ... to 2020″, provides key market data on the ... report provides value, in millions of US dollars, ... dollars) within market segments Invasive Body Contouring Devices ... Radio Frequency-Assisted Liposuction (RFAL) Devices, Ultrasound-Assisted Liposuction (UAL) ...
Breaking Medicine Technology:Heptares to Present on Structure-Based Drug Design Using G Protein-Coupled Receptors at Inaugural Chemistry & Engineering News Virtual Symposium 2Two New Studies Show Decipher Genomic Prostate Cancer Test Charts Best Course of Treatment and Influences Patient Outcomes 2Two New Studies Show Decipher Genomic Prostate Cancer Test Charts Best Course of Treatment and Influences Patient Outcomes 3Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 2Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 3Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 4Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 5
... 2011 /PRNewswire-Asia-FirstCall/ -- Dehaier Medical Systems ... emerging leader in the development, assembly, marketing and sale ... today announced that it was granted three new patents ... of China ("SIPO"). The patent awards were related to ...
... Cellular Dynamics International (CDI) today announced the online publication ... demonstrating for the first time a methodology for researchers ... blood samples through the creation of induced pluripotent stem ... B-cell lines reprogrammed to EBV-free induced pluripotent stem cells," ...
Cached Medicine Technology:Dehaier Strengthens Intellectual Property Portfolio 2Dehaier Strengthens Intellectual Property Portfolio 3Cellular Dynamics International Unlocks the Potential of Banked Blood Samples 2
Full Handle Laseredge Stab Blade Knife, 45 blade. Blade tip dimension: 8.9 mm x 1.9 mm x 1.9 mm....
Full Handle Laseredge Stab Blade Knife, 15 blade. Blade tip dimension: 3 mm x 1.0 mm x 3.0 mm....
19 Gauge. Reusable. Block of 4 each....
18 gauge straight. Fine tip. Lightweight design offers precise hemostasis. Pencil design minimizes tissue trauma and induced astigmatism. Knurled handle provides a sure grip and better manipulation....
Medicine Products: