Navigation Links
Outwitting immunity to treat disease: Start-up raises 37 millions dollars
Date:5/5/2014

in PNAS and received an enormous amount of attention.

"The technology delivers proteins, be they autoimmune antigens or protein drugs, in a manner that re-trains the immune system to accept them as the body's own," explains Hubbell "We are delighted that leading biotech venture funds have recognized the value of our approach, providing the necessary financial means to move forward."

Anokion's mission is to commercialize this discovery so that it can move out of the lab and into use as a treatment for disease. For now, the researchers are concentrating on a specific kind of white blood cell, T lymphocytes, that are implicated in many autoimmune and allergic diseases, including multiple sclerosis and type I diabetes.

The technology has a far wider potential, however. Protein drugs are used to treat diseases such as cancer and a number of genetic diseases such as hemophilia. Despite their effectiveness in treating these diseases, the body frequently recognizes these proteins as foreign and mounts an immune response against them, sometimes even after one or a few doses. After this, the body neutralizes the protein drugs that have been developed to heal it.

Using Anokion's technique, the drug could be administered over a much longer period by teaching the immune system to leave it alone. Multiple therapeutic molecules that trigger immune reactions have been withdrawn after clinical trials due to these immunogenicity challenges. The researchers think that many of these could be rehabilitated if the immune response of the T-cells during treatment could be controlled.

Anokion is planning clinical trials for 2017. They will initially test their technology in conjunction with a drug known to trigger strong immune reactions before moving on to autoimmune diseases.


'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers generate immunity against tumor vessel protein
2. Testosterone-regulated genes may affect vaccine-induced immunity
3. Combat the Flu with Immunity Products from Kirkman®
4. Maternal smoking may impair infant immunity, causing a broad range of infections
5. Wiley launches new open access journal: Immunity, Inflammation and Disease
6. Anxiety about relationships may lower immunity, increase vulnerability to illness
7. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
8. From herd immunity and complacency to group panic: How vaccine scares unfold
9. Study unveils new approach to treating brittle bone disease
10. Study points to potential revision of treatment guidelines for bleeding ulcers
11. Vibrating capsule shows promising results in treating chronic constipation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... ... Local filmmakers and now co-hosts of the up and coming podcast Path11 Podcast ... great success in launching their Path11 Podcast with 23 episodes released since April 2015. ... the well known Spiritual Catalyst and Linda Howe, leader in the field of Akashic ...
(Date:9/3/2015)... ... September 03, 2015 , ... Doctor Kayode Sotonwa can ... professionals out there. His perspective on internal medicine keeps patients happy and healthy, something ... is important regardless of the season, but even more so in the fall, when ...
(Date:9/2/2015)... ... , ... The Aspen Clinic (TAC), located in Basalt, Colorado, today ... inspiring wellness in the Roaring Fork Valley and beyond. , Amanda Wagner, Executive Director ... to fitness - we are much more than a gym. Our fitness and ...
(Date:9/2/2015)... ... September 03, 2015 , ... ... University Bloomberg School of Public Health and an internationally recognized scholar on obesity ... for 2015-16. Dr. Bleich, a Baltimore native and 1996 graduate of Garrison Forest ...
(Date:9/2/2015)... ... September 02, 2015 , ... Chris Harrison of Harrison’s Footwear of ... a simple decision, really,” says Chris. “We have a lot of repeat customers, and ... that work best for them—so we’ve given them the convenience of ordering from home.” ...
Breaking Medicine News(10 mins):Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3Health News:Doctor Kayode Sotonwa Highlights Expert Tips for Staying in Shape This Fall 2Health News:TAC Introduces New Retreats for Fall Fitness 2Health News:Dr. Sara Bleich, Garrison Forest Graduate, Selected for 2015-16 Class of White House Fellows 2Health News:Harrison's Comfort Footwear Announces Expansion with New CHarrison Online Store 2
... study says , , TUESDAY, Feb. 12 (HealthDay News) -- Americans ... pain, but new research suggests those extra dollars aren,t buying ... the authors of a study in the Feb. 13 issue ... but the lack of results weren,t. , "This calls into ...
... parent of Northwestern Memorial Hospital, appointed,at its January ... Northwestern,Memorial Foundation,s Boards of Directors., Trina D. ... of the Friends of Prentice,board of directors and ... Committee. Gordon is chairman of Boyden World,Corporation,s board ...
... 12 NHS Choices ( http://www.nhs.uk ),the online ... interactive tool aimed,to help people better understand the ... NHS accredited information, the food allergy symptom checker,( ... whether they have either a food allergy or ...
... The recent influenza,outbreaks across the country, resulting in at ... reminder that the influenza virus is a serious disease,and ... influenza hospitalizes more than 20,000 children,younger than 5 years ... and causes,approximately 100 deaths. These statistics are particularly tragic ...
... Feb. 12 A proposed,regulation to improve the ... by fostering the establishment of Patient Safety Organizations,(PSOs) ... Health and Human,Services (HHS)., PSOs are private ... patient safety events reported by health care providers. ...
... jaw adjustment, BLOOMINGTON, Ind., Feb. 12 A ... Medicine is advocating for the medical,community to provide relief ... sometimes deadly sleep apnea by using a common and ... just amazing that a few millimeters of adjustment, bringing ...
Cached Medicine News:Health News: Back Pain Spending Up, Relief Down 2Health News: Back Pain Spending Up, Relief Down 3Health News:Northwestern Memorial HealthCare and Northwestern Memorial Foundation Elect New Members to Board of Directors 2Health News:Childhood Influenza Immunization Coalition Responds to Recent Influenza Outbreaks 2Health News:New Patient Safety Proposed Regulation Aims to Improve Health Care Quality and Patient Safety 2Health News:New Patient Safety Proposed Regulation Aims to Improve Health Care Quality and Patient Safety 3Health News:New Patient Safety Proposed Regulation Aims to Improve Health Care Quality and Patient Safety 4Health News:Dental Devices Offer a Simple Solution for Sleep 2Health News:Dental Devices Offer a Simple Solution for Sleep 3
(Date:9/3/2015)... and REHOVOT, Israel, Sept. 3, 2015 ... and developing innovative therapies for ear, nose, and throat ... Company,s Newport Gateway office complex to be the location ... the move by end of September and will have ... U.S. Headquarters: OticPharma, Inc. 19900 MacArthur Blvd., ...
(Date:9/2/2015)... YORK , Sept. 2, 2015 ... by the collapse of one or more vertebral ... patients. Osteoporosis, a degenerative bone disease, is a ... bone disease, multiple myeloma, metastatic spinal tumors, and ... can undergo vertebroplasty and kyphoplasty to rectify the ...
(Date:9/2/2015)... , Sept. 2, 2015 This report ... the current and future prospects of the global ... health and assists medical practitioners in deciding the ... progression during treatment. Multi-parameter patient monitoring is effective ... disease. Geriatric population is observed to be at ...
Breaking Medicine Technology:OticPharma Establishes U.S. Headquarters in Orange County, California 2Global Balloon Kyphoplasty Market 2015-2019 2Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 2Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 3
... to do the exams you want: ,Four probe ... the easiest water path probe in the industry, ... exactly what you need to. From full ... chamber, the P60 provides the clarity of images ...
... will find the samaritan AED easy ... medical and rescue professionals) will appreciate ... manual override, and the ECG monitoring ... AED is an exceptionally well-engineered, lightweight ...
... extraordinary combination of features make the ... multi-specialty clinical environment. The versatility and ... hardware allows you to perform a ... high-quality results., ,The ideal choice for ...
Assay for Anti-HTLV-I and Anti-HTLV-II...
Medicine Products: