Navigation Links
Outwitting immunity to treat disease: Start-up raises 37 millions dollars
Date:5/5/2014

in PNAS and received an enormous amount of attention.

"The technology delivers proteins, be they autoimmune antigens or protein drugs, in a manner that re-trains the immune system to accept them as the body's own," explains Hubbell "We are delighted that leading biotech venture funds have recognized the value of our approach, providing the necessary financial means to move forward."

Anokion's mission is to commercialize this discovery so that it can move out of the lab and into use as a treatment for disease. For now, the researchers are concentrating on a specific kind of white blood cell, T lymphocytes, that are implicated in many autoimmune and allergic diseases, including multiple sclerosis and type I diabetes.

The technology has a far wider potential, however. Protein drugs are used to treat diseases such as cancer and a number of genetic diseases such as hemophilia. Despite their effectiveness in treating these diseases, the body frequently recognizes these proteins as foreign and mounts an immune response against them, sometimes even after one or a few doses. After this, the body neutralizes the protein drugs that have been developed to heal it.

Using Anokion's technique, the drug could be administered over a much longer period by teaching the immune system to leave it alone. Multiple therapeutic molecules that trigger immune reactions have been withdrawn after clinical trials due to these immunogenicity challenges. The researchers think that many of these could be rehabilitated if the immune response of the T-cells during treatment could be controlled.

Anokion is planning clinical trials for 2017. They will initially test their technology in conjunction with a drug known to trigger strong immune reactions before moving on to autoimmune diseases.


'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers generate immunity against tumor vessel protein
2. Testosterone-regulated genes may affect vaccine-induced immunity
3. Combat the Flu with Immunity Products from Kirkman®
4. Maternal smoking may impair infant immunity, causing a broad range of infections
5. Wiley launches new open access journal: Immunity, Inflammation and Disease
6. Anxiety about relationships may lower immunity, increase vulnerability to illness
7. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
8. From herd immunity and complacency to group panic: How vaccine scares unfold
9. Study unveils new approach to treating brittle bone disease
10. Study points to potential revision of treatment guidelines for bleeding ulcers
11. Vibrating capsule shows promising results in treating chronic constipation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... July 03, 2015 , ... Talcum powder attorneys representing clients in national ... Powder Cancer Lawsuit Center website. Just as the previous version did, the new website ... timely lawsuit updates and ovarian cancer warning information. The site is routinely updated with ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ” was featured ... coolest technology products available to consumers. Amanda Forstrom, a technology expert and special reporter ... great for documenting memories. , Almost every smartphone has an incredibly powerful camera built ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Celebrity Dresses is currently running ... to those of celebrities will have the opportunity to get 10% discount on orders ... that people do not have to use coupon codes or remember redemption codes. ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is ... is now the 19th sweetFrog store located in the Lone Star State. The premium ... growing companies in 2014. , The store, which opened July 1 at Duke’s Travel ...
(Date:7/2/2015)... ... July 02, 2015 , ... ... retrofit project at the University of Minnesota, they knew it would save the ... also be an award-winning choice: the total energy savings after installation was an ...
Breaking Medicine News(10 mins):Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2
... , , HARRISBURG, Pa., July ... received free dental care, valued at nearly $160,000, in the ... United Concordia Dental. , , ... provide free preventive services to those who cannot afford dental ...
... , LOS ANGELES, July 23 This week ... and Policy is launching its most comprehensive community outreach campaign ever to ... who have HIV does not know it. , , ... Titled "Virus," the multi-faceted campaign is designed to raise doubt and make ...
... , MIAMI, July 23 Following a successful ... a leader in sports nutrition for over 40 years, continues to ... Twinlab,s 2009 Mobile Beach Bash Celebration, ... Florida. For those eager to show-off their six-pack abs for a ...
... , DULUTH, Ga., July 23 /PRNewswire/ -- Get ... screenings to NHRA -- National Hot Rod Association -- fans at selected ... exhibiting at several recent NHRA race events, provides free blood ... damage derma-scans to the race attendees. While Get Screened America focuses ...
... , SUNRISE, Fla., July 23 Bioheart, Inc. ... devices and biologics that help monitor, diagnose and treat heart ... for presentation at the Heart Failure Society of America (HFSA) ... , Chris O,Connor, MD, Head of Heart ...
... stem-like cells have been implicated in the genesis of ... Medical Center,s Maxine Dunitz Neurosurgical Institute have isolated stem-like ... cells to generate new tumors in laboratory mice. Targeting ... strategy in the fight against malignant and benign tumors. ...
Cached Medicine News:Health News:More than 1,000 Underinsured and Uninsured Individuals Receive Free Dental Care 2Health News:Los Angeles County Launches Its Most Comprehensive Campaign Ever to Encourage HIV Testing 2Health News:Los Angeles County Launches Its Most Comprehensive Campaign Ever to Encourage HIV Testing 3Health News:Twinlab's(R) Mobile Beach Bash Heats Up After a Successful Kick-Off of the 2009 RateYourAbs.com Contest 2Health News:Get Screened America Goes After The 'Silent Killers' 2Health News:Bioheart Announces Acceptance of Marvel-1 Data for Presentation at the Heart Failure Society of America (HFSA) Meeting 2Health News:Bioheart Announces Acceptance of Marvel-1 Data for Presentation at the Heart Failure Society of America (HFSA) Meeting 3Health News:Study provides documentation that tumor 'stem-like cells' exist in benign tumors 2Health News:Study provides documentation that tumor 'stem-like cells' exist in benign tumors 3
(Date:7/2/2015)... , July 2, 2015 ResMed Inc. (NYSE: ... quarter and fiscal year ended June 30, 2015 results on ... market close. A press release with ResMed,s results will be ... will host a webcast to discuss operating results and future ... at 1:30 p.m. US Pacific Time and the live webcast ...
(Date:7/2/2015)... OXFORD, England , July 2, 2015 ... commonly known as ,Friendly Aedes aegypti , ... of Juazeiro, Brazil by 95%, ...      (Logo: http://photos.prnewswire.com/prnh/20150630/227348LOGO) , The ... of a trial of Oxitec,s genetically engineered mosquitoes. The ...
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/nlfg34/cancer ) has announced ... and by Application - Forecast to 2020" report to their ... reach $13.1 Billion in 2020 from an estimated $7.1 Billion in ... is dominated by North America , followed by ... Rest of the World (RoW). The cancer diagnostics market in ...
Breaking Medicine Technology:ResMed to Announce Fourth Quarter and Fiscal Year-End 2015 Results 2Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 2Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 3Global Cancer Diagnostics Market Report 2015 - Technology, Imaging and by Applications Forecasts to 2020 for the $13 Billion Industry 2
... NEW ORLEANS--(BUSINESS WIRE)--Mar 27, 2007 - Pfizer announced ... costs by significantly reducing the risk of,cardiovascular events ... economic analyses. The data were presented at the,annual ... of these analyses suggests that even with the ...
... Nuts May Reduce Inflammation After,Menopause; Weight-Loss Surgery Improves ... 28, 2007 /PRNewswire/ -- People who have,type 2 ... as,they age, though researchers are uncertain what accounts ... a new study being,published in the April issue ...
Cached Medicine Technology:Lipitor Significantly Lowered Hospitalization Costs for Patients,with Heart Disease, Two New Analyses Show 2Lipitor Significantly Lowered Hospitalization Costs for Patients,with Heart Disease, Two New Analyses Show 3Lipitor Significantly Lowered Hospitalization Costs for Patients,with Heart Disease, Two New Analyses Show 4Diabetes Linked to Higher Parkinson's Risk 2Diabetes Linked to Higher Parkinson's Risk 3Diabetes Linked to Higher Parkinson's Risk 4
Biotest ELPHA (=Enzyme Linked Probe Hybridization Assay) for class I and class II HLA typing shows convincing advantages for your lab routine....
This ELISA test is used for the detection and semi-quantitation of lgG antibobies to proteinase 3(pr3) in human sera, as an aid to the diagnosis of wegener s granulomatosis....
... for the semi-quantitative determination of specific ... serum. The results of the anti-GBM.assay ... in the diagnosis of diseases associated ... including Goodpastures Syndrome. Levels of these ...
The assay is an immunometric ('sandwich') EIA for the quantitative measurement of LH in human serum or plasma. LH in the sample is bound by 2 monoclonal anti-LH antibodies directed at different epito...
Medicine Products: