Navigation Links
Outcomes of steroid therapy following surgery for infants with bile duct disorder
Date:5/3/2014

Among infants who underwent surgery to repair bile ducts that do not drain properly (biliary atresia), the administration of high-dose steroid therapy following surgery did not significantly improve bile drainage after 6 months, although a small clinical benefit could not be excluded, according to a study in the May 7 issue of JAMA, a theme issue on child health. This issue is being released early to coincide with the Pediatric Academic Societies Annual Meeting.

Biliary atresia progresses to end-stage liver disease (cirrhosis) in more than 70 percent of affected children and is the leading indication for pediatric liver transplantation in the world, accounting for about 50 percent of liver transplants in children. Hepatoportoenterostomy (surgery to improve bile drainage) results in successful bile drainage in only about half of patients with biliary atresia treated in the United States, underscoring the need for additional therapies to improve survival without liver transplantation, according to background information in the article. There have been conflicting reports regarding the effectiveness of the use of corticosteroids to improve bile flow following surgery.

Jorge A. Bezerra, M.D., of Cincinnati Children's Hospital Medical Center, Cincinnati, and colleagues randomly assigned 140 infants (average age, 2.3 months) to receive high-dose steroid therapy or placebo following surgery to improve bile drainage.

The researchers found that the proportion of infants with improved bile drainage was not significantly improved by steroids at 6 months following surgery (58.6 percent of steroids group vs 48.6 percent of placebo group). The adjusted absolute risk difference was 8.7 percent.

Survival without liver transplantation at 2 years of age for infants treated with steroids was nearly identical to those who received placebo (58.7 percent vs. 59.4 percent). Serious adverse events were common in both treatment groups (81.4 p
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
The JAMA Network Journals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New model can predict therapy outcomes in prostate cancer with bone metastasis
2. Drug-eluting stents demonstrate better outcomes after 1 year than bare metal stents
3. USF study finds stem cell combination therapy improves traumatic brain injury outcomes
4. Obesity and diabetes have adverse effects on cancer outcomes
5. Unilateral radiation therapy for advanced stage tonsil cancer results in favorable outcomes
6. UT Southwestern launches Center for Patient-Centered Outcomes Research
7. Extended outcomes from APBI show tumor control, breast cosmesis and minimal late toxicity
8. Good outcomes with staged surgery for epilepsy in children
9. Mayo Clinic study finds standardized protocol and surgery improve mortality outcomes
10. Quality improvement initiative improves asthma outcomes in teens
11. ROI grants $200,000 to evaluate the value of RT and patient outcomes among lung cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Energy Textiles is excited to announce ... the world’s leading responsive textile, can now be ... are a number of benefits to wearing Celliant, ... balanced body temperature; which can lead to enhanced ... athletic performance; and overall wellness. In addition, the ...
(Date:12/19/2014)... These vanadium reserves are mostly found ... 151,000 tons of vanadium were produced globally in 2013, ... increased at 6.7% AAGR during the period from 2001 ... being the largest consumer, accounted for more than 90% ... alloy and the chemical industry. , View Full Report ...
(Date:12/19/2014)... (HealthDay News) -- The intestinal bacteria that cause inflammatory ... may be inherited, researchers report. The findings, published ... help in efforts to prevent the disease and treat ... study authors added. "The intestinal bacteria, or ,gut ... have a big impact on your health for the ...
(Date:12/19/2014)... News) -- The cost of cancer treatment can cause ... finds. Researchers examined data from 1,000 people in ... or lung cancer. Of those patients, almost 900 had ... 100 had advanced cancer. Nearly half of the ... bills, which was linked with a poorer health-related quality ...
(Date:12/19/2014)... B. E. Smith, the only full-service leadership ... retained to lead a national chief financial officer ... Park, Colo. The top executive search firm in the ... than 900 healthcare executives into organizations. , Estes ... access hospital and level IV trauma center, with a ...
Breaking Medicine News(10 mins):Health News:Energy Textiles Launches Celliant Revitalizing Bedsheets 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3Health News:Crohn's, Colitis May Have Genetic Underpinnings, Study Finds 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 3
... meet increasing demand for,pharmaceutical packaging in China, ... HON ) announced,today that it has signed a ... Ltd., to provide the Chinese company with,Honeywell,s Aclar(R) ... also provide technical services and training to Haishun,as ...
... 6 CJPS Enterprises, LLC (, http://www.CJPS-Enterprises.com ... resources,to help companies that depend on the automotive ... "Although both industries seem similar in what they ... companies trying to embark,on this diversification initiative have ...
... an independent factor in cancer survival rates and should not ... a study in the November issue of IJCP , ... team of hospital and University-based researchers from Barcelona, Spain, carried ... with cancer. , "We found that there were a ...
... in German . , Opting for ... warning signs of lymphedema: that,s how women with breast ... German Institute for Quality and Efficiency in Health Care ... themselves from this common and distressing adverse effect of ...
... Conference on Cell Therapy for Cardiovascular Disease (IC3D) ... evolving field of cell-based therapies for treating cardiovascular ... "Cellular and Molecular Building Blocks: Strategies for Cardiovascular ... will convene to present basic, core discussions on ...
... 6 Let,s face it: Because of the,economy, typical ... are,becoming luxuries. Today,s budget trimmers who regularly attend a ... make a small,investment in a home yoga practice and ... Balanced Living magazine,s November,issue, now on newsstands, features "The ...
Cached Medicine News:Health News:Honeywell Signs Supply Agreement with Chinese Company for Aclar(R) Film 2Health News:Honeywell Signs Supply Agreement with Chinese Company for Aclar(R) Film 3Health News:CJPS Enterprises to Increase Focus on Automotive Diversification 2Health News:Age is not a key factor in cancer survival, but clinical trials exclude older patients 2Health News:Age is not a key factor in cancer survival, but clinical trials exclude older patients 3Health News:How women can improve their quality of life after breast cancer treatment 2Health News:5th Annual Global Conference on Stem Cell Therapy to be held Jan. 13-16, 2009 in NYC 2Health News:In These Stressful, Budget-Busting Times, It's Wise to Invest in a Home Yoga Practice, Says Natural Solutions Magazine 2
(Date:12/19/2014)... Dec. 19, 2014 Breckenridge Pharmaceutical, Inc. announced ... with MSN Laboratories Pvt. Ltd. ( Hyderabad, India ... commercialize several new ANDAs.  Under the terms of the ... exclusively to Breckenridge for the U.S. market, and Breckenridge ... Breckenridge and MSN have agreed to develop an oral ...
(Date:12/19/2014)... N.C. , Dec. 19, 2014 ... optimize a product,s web presence to reflect the ... websites, in particular, must meet the needs of ... and culture. According to recent ... than half of the participating companies averaged more ...
(Date:12/19/2014)... , Dec. 19, 2014  Monarch America Inc. (OTCQB: ... Corp.) is pleased to provide this review of the ... in 2015. "Over this past year, we ... I am extremely proud to say that Monarch America ... than it has ever been," stated Eric Hagen ...
Breaking Medicine Technology:Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Building a Best-in-Class Pharma Global Brand Website 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: