Navigation Links
Our own treacherous immune genes can cause cancer after viral infection
Date:6/5/2014

dly fire' more likely. Alternatively, there may well be something about the virus that causes the APOBEC response to wrongly target the body's own genes for mutation."

Mutated PIK3CA (p110α) protein is known to play a key role in the development of a range of cancers, so it is a hot target for new drugs. The new research could explain why particular PIK3CA mutation variants are so commonly found in HPV-associated cancers.

"While it is too early to consider targeting APOBEC genes to prevent tumour formation, it is nonetheless fascinating to work out how HPV drives tumour formation through their activity," says co-lead author Ankur Chakravarthy, a PhD student in the Tumour Virus team. The team's aim is now to learn what happens following HPV infection of cells in which APOBEC genes have been deleted.

The research could also inform screening procedures, as there are variants of particular APOBEC genes that are known to affect cancer risk. For example, a variant of the specific gene APOBEC3B is known to approximately double breast cancer risk. This variant is common in East Asia, with approximately 80% of Indonesians carrying the gene variant. By contrast, only around 2% of the African population carry this variant.

"Previous studies have shown that APOBECs cause mutations in a range of cancers but our finding that they mutate key cancer genes implicates them as drivers of tumour development, particularly in HPV-associated cancers. It will be interesting to see whether such APOBEC variants can predict the risk of developing cancer after HPV infections," says Dr Tim Fenton. "If at-risk groups could be identified by genetic testing, this could have important implications for HPV screening and vaccination programmes."


'/>"/>

Contact: Harry Dayantis
h.dayantis@ucl.ac.uk
44-020-310-83844
University College London
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New therapies harness power of the immune system against cancer
2. Immune therapy for advanced bladder cancer yields promising results
3. New tick-borne disease threatens primarily immune suppressed persons
4. 2014 Avant-Garde Awards focus on strengthening the immune system
5. UBC scientists find new way to mobilize immune system against viruses
6. A form of immune therapy might be effective for multiple myeloma
7. Immune cells found to fuel colon cancer stem cells
8. Autoimmune diseases may succumb to new drug strategy
9. Penn researchers find link between sleep and immune function in fruit flies
10. Study sheds light on how the immune system protects children from malaria
11. Is Parkinsons an autoimmune disease?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 26, 2014 DW-InductionHeating.com (DaWei Induction Heating ... researching and developing, producing and marketing of a series ... business announces their new series of induction brazing ... the company, induction brazing refers to the ... filler material and heat. The manager says that there ...
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 ... Market Analysis to 2023” focuses on the current ... opportunities in the colorectal cancer market. Stivarga is ... of colon or rectal cancer. Boehringer Ingelheim is ... for the treatment of refractory CRC in the ...
(Date:12/25/2014)... 26, 2014 Recently, Dylan Queen, a ... excitedly released its collection of discounted prom dresses, most ... a senior spokesman of the company, the promotion is ... promotion is to expand the UK market. , The ... different colors, lengths, and styles: A-line strapless, empire strapless ...
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
(Date:12/25/2014)... 2014 (HealthDay News) -- Among early stage breast cancer ... half of one percent will eventually develop leukemia as ... The finding comes from a review of more ... 2007, and it suggests that the risk for developing ... had previously thought. "The frequency of bone marrow ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... Pharmaceutical Marketing Industry Due to New PhRMA Marketing ... Pharmaceutical marketers are taking on the 2009 ... a unique marketing company whose integrated engagement solutions ... sector. In the past two years the company ...
... Disease Depend on Plasma DonationANNAPOLIS, Md., Jan. 6 Kawasaki ... between the ages of two and five and is ... in the United States according to the American Heart ... globulin (IVIG), a plasma-derived therapy that replaces vital missing ...
... flow leader positioned for expanding role of patient flow ... has been helping its clients, now more than 700 ... The need to increase capacity and improve patient ... of U.S. hospitals have postponed building and expansion plans ...
... Music Organization Will Offer "The Prevention Plan(TM)" Health ... Preventive Medicine(R), the leader in disease prevention, today ... performing right organization that represents more than 375,000 ... Prevention Plan(TM) to its members at a discount. ...
... N.C., Jan. 6 Compass Group North America ... of Harwood Heights,Illinois-based KIMCO Corporation, a provider of ... sector. Through the acquisition, KIMCO,becomes a wholly owned ... a division of Compass Group North America focused ...
... Rising Medical Solutions, Inc. (Rising), a,leading medical ... Company will provide Medical Data Call services for ... data to the National Council on,Compensation Insurance, Inc. ... http://www.newscom.com/cgi-bin/prnh/20080206/AQW030LOGO-b ) , ...
Cached Medicine News:Health News:Kyp Systems Takes on the Challenge of New Pharmaceutical Marketing Guidelines 2Health News:Kyp Systems Takes on the Challenge of New Pharmaceutical Marketing Guidelines 3Health News:Kawasaki Disease Treated with Plasma-Derived Therapy 2Health News:TeleTracking Technologies to Focus on Growth 2Health News:TeleTracking Technologies to Focus on Growth 3Health News:U.S. Preventive Medicine(R) Strikes a Note with Broadcast Music, Inc. 2Health News:Compass Group North America Acquires KIMCO Corporation 2Health News:Rising Medical Solutions to Provide NCCI Medical Data Call Services 2
(Date:12/24/2014)... and LONDON , December 24, 2014 ... are expected to grow at an average rate of ... value and volume. Hip, knee and spine surgeries are ... in emerging economies they have a lower penetration. Increased ... the use of composites. Non-metallic orthopedic devices have gained ...
(Date:12/24/2014)...  Advanced Medical Isotope Corporation ("AMIC") (OTCQB: ADMD), a ... development of brachytherapy devices and medical isotopes for ... has filed a de novo submission ... marketing clearance for its patented Y-90 RadioGel(TM) device ... Drug and Cosmetic Act (the "Act").  ...
(Date:12/24/2014)... Dec. 23, 2014   Synageva BioPharma Corp. ... company developing therapeutic products for rare disorders, today ... of the Marketing Authorization Application (MAA) for sebelipase ... the company,s request for accelerated assessment, which has ... time.   The MAA, and the ...
Breaking Medicine Technology:Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... 2011 As NFL coaches and players face a dramatically ... team,s preparation will be gaining a competitive edge as it ... Today, Polar USA and the Atlanta Falcons announced that the ... Heart Rate Training System" of the Atlanta Falcons. ...
... CINCINNATI, Sept. 7, 2011 HealthWarehouse.com, Inc. (OTC: HEWA) ... that Lalit Dhadphale, president and CEO of HealthWarehouse.com, will ...  The presentation will begin at 10:00 a.m. Eastern Time ... invited to listen to a live web cast of ...
Cached Medicine Technology:Polar Team2 Pro Set Solution Is Official Heart Rate Training System for the Atlanta Falcons 2Polar Team2 Pro Set Solution Is Official Heart Rate Training System for the Atlanta Falcons 3
... one of our highly featured models. This model has ... target using the mouse to have the patient look ... allow the unit to photograph a particular area on ... after you have taken the picture you can ascertain ...
... laser combines excellent cutting, ablation and ... procedures. It is also extremely effective ... stones of all compositions, making it ... its laser light is transmitted through ...
... Thanks to the progress and perfecting ... techniques have acquired a more strategic role ... technology in this sector has certainly contributed ... various urological pathologies that are becoming more ...
... PhotoLightFACIAL facial skin treatment, vascular ... Incorporates a wide range ... multiple hand pieces and large ... the most flexibility. Compact ...
Medicine Products: