Navigation Links
Our normal genetics may influence cancer growth, too

COLUMBUS, Ohio The genes we possess not only determine the color of our eyes and hair and how our bodies grow, they might also influence the changes that occur in tumors when we develop cancer.

A study by researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) suggests that our normal genetic background the genetic variations that we inherit contributes to the kinds of DNA changes that occur in tumor cells as cancer develops.

The researchers compared multiple independent tumors from people with a form of skin cancer called squamous cell carcinoma (SCC) for losses and gains of DNA in tumor cells. They found that the pattern of these changes is quite similar in tumors from the same person but quite different in tumors from different individuals.

The findings, published in a recent issue of PLoS Genetics, may offer a new way to identify individuals at greater risk for developing cancer, the researchers say.

"Our data strongly support the idea that an individual's normal genetic constitution can strongly influence the genetic changes that occur when a person develops cancer," says study leader Amanda Toland, assistant professor of medicine and a specialist in the genetics of cancer susceptibility at the OSUCCC James.

"They may also provide another strategy to identify genetic variations within healthy individuals that may increase their odds of developing cancer," she adds.

Toland and her collaborators analyzed 222 SCC tumors from 135 organ transplant recipients, who as a group are 65 to 250 times more likely to develop SCC than people in the general population. The researchers examined three or more separate tumors from 25 of these individuals.

They compared the genetic profiles of tumors from the same individual with those from other individuals for DNA copy number changes.

They found that the changes in SCCs from the same patient were statistically similar but significantly different when compared with other patients. They also found that in some cases a particular kind of genetic change is preferentially selected in tumors from the same individual.

"Overall," Toland says, "our findings provide strong evidence that an individual's genetic background plays a key role in driving the changes that occur in tumors during cancer development."


Contact: Darrell E. Ward
Ohio State University Medical Center

Related medicine news :

1. Older women with normal T-scores may not need bone mineral density screening for 10 years
2. Could brain abnormalities cause antisocial behavior and drug abuse in boys?
3. Study Suggests Statins Could Help Some With Normal Cholesterol
4. Experts Predict Normal H1N1 Flu Season This Year
5. Vision Abnormality Seen in Close Relatives of Autism Patients
6. Childhood cancer survivors may have abnormal long-term cardiac function
7. Abnormal brain activity in migraineurs is not restricted to attacks
8. Thyroid Function at High End of Normal Tied to Miscarriage Risk
9. Normal Blood Pressure in Male Teens a Warning Sign
10. Specially trained nurse practitioner detected same breast abnormalities as surgeon
11. Harmless Brain Abnormalities in Kids Pose Disclosure Dilemmas
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Vision Group Holdings, the largest LASIK provider in ... brands including The LASIK Vision Institute and TLC Laser Eye Centers, Vision Group Holdings ... laser vision correction. , Global Laser Vision will continue to operate in San Diego ...
(Date:10/13/2015)... ... October 13, 2015 , ... PhyMed Healthcare Group ... announced its partnership with WPC Healthcare , a provider of predictive analytics ... the data into an aggregated data repository necessary to perform reporting and analytics ...
(Date:10/13/2015)... ... October 13, 2015 , ... Symposium Chairman, Dr. Rod J. ... Dallas Cosmetic Symposium to be held March 2nd and 3rd, 2016. The annual meeting, ... plastic surgeons and cosmetic physicians from around the world. , Key topics at this ...
(Date:10/13/2015)... ... October 13, 2015 , ... e-con Systems Inc., a leading embedded design ... the industry’s first RGB-IR pixel format camera with a USB 3.0 interface and ... See3CAM family of UVC USB 3.0 cameras, is based on the 1/3-inch OV4682 - ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... today their Title Sponsorship of Synergy 2015. The annual WennSoft KEY2ACT user conference ... Valley Ranch and will unite customers, partners, WennSoft team members and sponsors to ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015  Vitamin Angels – a charity that ... need of nutritional support - announced its work continues ... Nations (UN). The UN,s newly established Global Goals - ... recent follow up to the Millennium Development Goals established ... The new 17 Global Goals intend to address three ...
(Date:10/13/2015)... Generational Equity , a leading mergers and acquisitions advisor ... acquisition of its client, Quality Medical Rentals ... by Meridian Biomedical, Inc. (Meridian), headquartered in Colorado.  The ... Florida . To learn more, visit ... To learn more, visit . --> ...
(Date:10/13/2015)... -- The spine division of Zimmer Biomet (NYSE and SIX: ... its portfolio of innovative clinical solutions and technologies at ... 14-17, 2015, in Chicago , Illinois.  ... "Supplemental MIS Fixation Options for LLIF" NASS ... 1 p.m. --> "Supplemental MIS Fixation Options ...
Breaking Medicine Technology: