The findings indicate that laminar and columnar properties of the neocortex are not unique to mammals, and may in fact have evolved from cells and circuits in much more ancient vertebrates.
"The belief that cortical microcircuitry was a unique property of mammalian brains was largely based on the lack of apparent lamination in other species, and the widespread notion that non-mammalian vertebrates were not capable of performing complex cognitive and analytic processing of sensory information like that associated with the neocortex of mammals," said Karten.
"Animals like birds were viewed as lovely automata capable only of stereotyped activity."
But this kind of thinking presented a serious problem for neurobiologists trying to figure out the evolutionary origins of the mammalian cortex, he said. Namely, where did all of that complex circuitry come from and when did it first evolve?
Karten's research supplies the beginnings of an answer: From an ancestor common to both mammals and birds that dates back at least 300 million years.
The new research has contemporary, practical import as well, said Karten. The similarity between mammalian and avian cortices adds support to the utility of birds as suitable animal models in diverse brain studies.
"Studies indicate that the computational microcircuits underlying complex behaviors are common to many vertebrates," Karten said. "This work supports the growing recognition of the stability of circuits during evolution and the role of the genome in producing stable patterns. The question may now shift from the origins of the mammalian cortex to asking about the changes that occur in the final p
|Contact: Scott LaFee|
University of California - San Diego