Navigation Links
Our brain has switch board to guide behavior in response to external stimuli
Date:2/14/2014

How do our brains combine information from the external world (sensory stimulation) with information on our internal state such as hunger, fear or stress? NERF-scientists demonstrate that the habenula, a specific part in our brain consisting of neural circuits, acts as a gate for sensory information, thus regulating behavior in response to external stimuli.

Emre Yaksi (NERF VIB/imec/KU Leuven): "Our brain has high levels of spontaneous activity, even in the absence of sensory stimulation. We think that this spontaneous neural activity in combination with sensory stimulation results in a particular internal state of the habenula. By this functional organization the habenula acts as a kind of switch board, selecting certain sensory information and sending it to the downstream brainstem areas. Thus the habenula regulats our behavior. It will be interesting to test whether experience or learning can alter the functional organization of these circuits."

Unraveling neural circuits

Neuroscientists all over the world are gradually unraveling the processes in our brain. However our brain still remains a mystery. The activity of single neurons and the functioning of 'one-to-one' interactions have been examined in detail. Yet, the information processing at the level of neural circuits is less well-understood. Emre Yaksi and his NERF-colleagues integrate neurobiology and nano-scale engineering to study brain function at multiple levels of detail. This multidisciplinary approach enables the researchers to look beyond the brain cells, and it provides them with great tools to study neural circuits and their link with behavior.

Exploring brain structures in zebrafish

Zebrafish is a useful model organism for neurological research. To find out how brains combine external and internal stimuli, Suresh Kumar Jetti, Nuria Vendrell Llopis and Emre Yaksi focused on the dorsal habenula (dHb) in zebrafish. The dHb is an equivalent of the habenula in mammals and relays information from the sensory areas to the brain region that regulates animal behavior under stress conditions. In zebrafish, the dHb receives input from cells of the olfactory bulbthus odors can trigger distinct behaviors (e.g. feeding, courtship, alarm).

Spontaneous activity is highly organized

The ongoing spontaneous activity in neurons was thought to be associated with several neurological phenomenons, such as sleep, or the learning and sensory process. The researchers observed that dHb is highly active even in the absence of any sensory stimulation. Moreover they showed that the spontaneous activity of dHb is not random but highly structured in the spatial clusters of neurons. Later the team showed that this spontaneous activity is very prominent during sensory stimulation and governs the odor responses in the dHb. The scientists their conclusion is that dHb acts like a switch board for the sensory information and is controlled by spontaneous activity.


'/>"/>

Contact: Kris Van der Beken
kris.vanderbeken@vib.be
32-473-783-435
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related medicine news :

1. Rebuilding the brain after stroke
2. Grant supports Cedars-Sinai study of possible links between air pollution and brain cancer
3. Brilliant blue G may shine in treating traumatic brain injuries
4. Males and females differ in specific brain structures
5. Long distance signals protect brain from viral infections
6. Study identifies protein to repair damaged brain tissue in MS
7. Toxin from brain cells triggers neuron loss in human ALS model
8. Monkeys that eat omega-3 rich diet show more developed brain networks
9. High long-term survival of most common pediatric brain tumor, less when radiation was used
10. Early rehabilitation important for recovery after severe traumatic brain injury
11. Quality of white matter in the brain is crucial for adding and multiplying
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: