Navigation Links
Ottawa researchers find new pathway connected to type 2 diabetes
Date:3/19/2014

Ottawa, ON, March 19, 2014 Scientists at the Children's Hospital of Eastern Ontario (CHEO) Research Institute have discovered a cellular pathway that is responsible for keeping blood sugar levels low in obese or pre-diabetic people, and may prevent the onset of Type 2 diabetes. The discovery published this month in a leading journal Nature Cell Biology.

Following a meal, beta cells found in islets of the pancreas secrete insulin that helps to store food energy for future use. The inability of islet beta cells to produce enough insulin leads to diabetes. Unlike other research that has focused on how to replicate beta cells, this study focused on how to make pre-existing beta cells more functional, or better at secreting insulin.

The research team, led by Canada Research Chair Dr. Robert Screaton, senior scientist at the CHEO Research Institute and associate professor at the University of Ottawa, started with a gene "knockout" strategy to remove a protein called SIK2 from all beta cells. They found that mice without SIK2 secrete less insulin during feeding because they fail to turn off a switch protein called p35, which prevents insulin secretion when blood sugar levels are low. The team also found that SIK2 works together with the protein PJA2 to turn off p35.

"We were very excited when we found obese animals had three times the amount of SIK2 in their beta cells, meaning they were working harder to compensate for high blood sugar by turning up SIK2," said Dr. Screaton. "Diabetic mice have lost this ability to turn up SIK2 and compensation is lost. The SIK2-p35-PJA2 pathway provides us with new targets to try and improve beta cell functionality to prevent and treat Type 2 diabetes."


'/>"/>
Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Alcohol & Drug Rehab Ottawa Launches Program Aimed at Reducing Adolescent Marijuana Addiction
2. Heritage Woods of Ottawa Affordable Assisted Living to Host Craft and Bake Sale
3. The Royal Mental Health Center of Ottawa Releases a Complete Mobile Application Suite for Veterans Coping with Operational Stress Injuries
4. 2013 Ottawa Consumer Choice Award Winners
5. Champion of Genetics funding to Ottawa researcher
6. Ottawa researcher named 2013 Champion of Genetics
7. Paul McCartney Tickets: Paul McCartney Tickets in Kanata Ottawa at the Scotiabank Place Go on Sale on Friday, April 26th at 10:00 a.m. Local Time
8. TEAL Ottawa Launches Skin Imperfection Treatments by Thermo LO
9. Don’t Compromise Your Health, Ottawa Residents!
10. Shoulder revision repair surgery not as successful 2 years later, say researchers
11. Researchers find significant increase in painkillers prescribed to US adults in the ER
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
Breaking Medicine Technology: