Navigation Links
Other stomach microbiota modulate resistance to H. pylori-driven ulcers
Date:3/25/2013

WASHINGTON, DC March 25, 2013 Mice with different naturally occurring stomach bacteria have distinct susceptibilities to disease caused by Helicobacter pylori, the well-known cause of ulcers in humans, according to a study published online ahead of print in the journal Infection and Immunity. This is the first study to document (in mice) that the presence of certain bacteria in the stomach microbiota can prevent pathology from H. pylori.

The gastro-intestinal tract is a veritable ecosystem packed with microbes, and over the last decade, investigators have been discovering that the species composition of that ecosystem can have a profound effect on human health. But the eureka moment that led to this study came "when we realized that mice from different vendors mount different responses to H. pylori infection," says principal investigator Karen Ottemann of the University of California, Santa Cruz.

Following this discovery, the researchers divided mice from the vendor, Taconic Farms, into three groups: mice treated with antibiotics in order to kill some of the resident bacteria, mice that were fed normal stomach bacteria after antibiotic treatment, and mice that were not treated. They then infected each group with H. pylori, and assayed the animals' stomachs for immune system cells.

"The antibiotic-treated mice had small quantities of particular inflammatory cells, called Th1 T helper cells," says Ottemann. Both the untreated mice, and the treated mice that were then fed normal stomach bacteria had normal (higher) levels of Th1 T helper cells. These results suggested that the normal stomach microbes contribute to disease caused by H. pylori, says Ottemann.

The researchers then determined that around 4,000 species of bacteria were different in the high- and low-inflammation (no antibiotics, and antibiotic-treated, respectively) mice. Notably, the mice with low inflammation "had elevated amounts of Clostridia, bacteria known to prevent inflammation in the intestine," says Ottemann. Thus, the Clostridia may be key to dampening H. pylori pathology, although that remains to be determined, she says.

Ottemann says that this research may lead to predicting future H. pylori disease, including ulcers and gastric cancer -- which has few treatment options and high mortality -- based on stomach microbiota.

"After we determine which microbes underlie H. pylori disease outcomes, we could test whether H. pylori-infected people harbor those particular bacteria, and target them for curing," says Ottemann. Alternatively, such people could receive the protective bacteria as probiotics. The latter might be a superior option, because while prone to ulcers in middle and advanced age, people who harbor H. pylori are less likely to get esophageal cancer and asthma.


'/>"/>
Contact: Garth Hogan
ghogan@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. New insights into when beach sand may become unsafe for digging and other contact
2. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
3. Immunotherapy for elderly cancer patients finds new promise in drug combination
4. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
5. Concerns about MRSA for expectant mothers may be unfounded
6. Another Drug Take-Back Day Scheduled for Saturday
7. Low-Income Mothers May Overfeed Their Infants
8. New global report says US lags behind 130 other nations in preterm birth rate
9. Screening for Other Health Problems May Aid COPD Survival
10. Stem cell sparing radiotherapy for head and neck cancer may avoid salivary gland damage
11. Genetic predictor of breast cancer response to chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:10/2/2017)... Oct. 2, 2017 Halo Labs announces the European launch ... called the HORIZON at MIBio 2017 in Cambridge, U.K ... visible particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity ... novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
Breaking Medicine Technology: