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Other highlights in the Oct. 30 JNCI
Date:10/30/2007

radiation. The risk of second cancers increases over time and remains elevated for over 40 years.

The 10-year survival rate for cervical cancer is nearly 70%. But exposure to radiation therapy and the presence of other risk factors among cervical cancer survivors, such as HPV infection, puts this population at high risk for second cancers.

Anil Chaturvedi, Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues collected data on 104,760 cervical cancer survivors from several Scandinavian countries and the United States. They calculated the incidence of second cancers among these women during a follow-up period of more than 40 years.

About 12,500 women were diagnosed with second cancers. These women were more likely to have HPV-related cancers or smoking-related cancers. Cervical cancer patients treated with radiation were at greater risk for all second cancers, compared with those treated with other methods, and were at particular risk of cancers at sites that were exposed to radiationthe colon, rectum, bladder, ovaries, and genitals. The 40-year risk of a second cancer was greater among women diagnosed with cervical cancer before age 50 than among women diagnosed after age 50.

The high cumulative risk of second primary cancers in cervical cancer survivors should prompt screening efforts in this group of women, the authors write.

Contact: National Cancer Institute press office, (301) 496-6641, ncipressofficers@mail.nih.gov

Sequential Randomization in Clinical Trials Points Out Promising Cancer Treatments

A novel trial design offers a way to select which promising drug combinations should be pursued in more advanced clinical trials. Because it is impossible to conduct randomized comparisons of all possible therapies, a new selection method was needed to identify the most promising ones.

Randall Millikan,
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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