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Other highlights in the Oct. 30 JNCI
Date:10/30/2007

Cancer-Killing Virus Shows Promise as Metastatic Cancer Treatment

The Seneca Valley Virus is a potent cancer killer and can differentiate between normal and cancerous cells. The virus may be a potential treatment for some metastatic cancers, such as small-cell lung cancer.

Cancer-killing viruses have been shown in clinical trials to be promising therapies for localized cancer. But so far their success has been limited in metastatic cancers. This could be due to the viruses targeting normal cells as well as cancer cells or the viruses being inactivated by a patients blood or immune system.

Paul Hallenbeck, Ph.D., of Neotropix in Malvern, Pa., and colleagues examined the cancer-killing potential of the newly discovered Seneca Valley Virus-001 in normal and tumor cell lines. They also tested the virus in human blood to assess whether it would be suitable for intravenous delivery. The researchers evaluated the safety and efficacy of the virus in mice with tumors derived from human small-cell lung cancer and childhood eye cancer cell lines.

The Seneca Valley Virus was more effective at killing the lung and eye cancer cell lines than the normal cells, and the virus was not inhibited in the blood. Among mice treated with the virus, there was a complete response in all the mice with lung cancer tumors and in the majority of those with eye cancer tumors.

The data in this report suggest that [the Seneca Valley Virus] may overcome many of the challenges faced by traditional therapies and other [cancer-killing] viruses, the authors write.

Contact: Paul Hallenbeck, (610) 296-8660, phallenbeck@neotropix.com


Cervical Cancer Survivors Are at Greater Risk of Second Cancers

Cervical cancer patients treated with radiation have an increased risk of second cancers, particularly in areas of the body previously exposed to high levels of
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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