Other highlights in the Jan. 8 JNCI (ne in kidney function and tumor developm...)

Other highlights in the Jan. 8 JNCI

Date:1/8/2008

ne in kidney function and tumor development.

The mice without the BHD gene had enlarged kidneys filled with cysts and died from kidney failure by the time they were three weeks old. Treatment with the drug rapamycin reduced kidney size and increased survival time.

Because BHD-targeted mice develop a striking kidney phenotype over a very short time, this model may be useful for the development and testing of new therapies or drugswith which to treat BHD patients and BHD-associated kidney cancers, the authors write.

Contact: National Cancer Institute press office, ncipressofficers@mail.nih.gov, (301) 496-6641

Tumor Viruses Regulate Telomeres to Assure Cell Proliferation

Human tumor viruses employ a variety of strategies for maintaining telomere length, which assist in the growth and survival of tumor cells.

Telomeres are the sections of DNA at the end of chromosomes that protect them from being degraded. Each time a cell divides, the telomeres shorten, giving normal cells a finite lifespan. Tumor cells are able to achieve cellular immortality by increasing the production of enzymes known as telomerase that can lengthen the telomeres.

In a review, Christophe Nicot, Ph.D., and graduate student Marcia Bellon and of the University of Kansas Medical Center in Kansas City discuss the many ways that human tumor viruses regulate these enzymes in order to maintain telomere stability and promote tumor cell survival and proliferation.

The diversity of strategies used by tumor viruses underscores the complexity oftelomerase regulation, the authors write.

Contact: Christophe Nicot, cnicot@kumc.edu, (913) 588-6724

Also in the January 8 JNCI:

http://www.eurekalert.org/emb_releases/2008-01/
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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