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Other highlights in the Feb. 26 JNCI
Date:2/26/2008

the most cost-effective screening protocols for both vaccinated and unvaccinated women included cytology during the early part of a womans life, followed by HPV DNA-based screening after age 30. This strategy differs from most commonly used screening practices.

The investigators emphasized that the frequency of screening could be reduced in vaccinated individuals and the switch to DNA-based screening delayed by five years, relative to unvaccinated women. The researchers estimated that cervical cancer risk could be reduced by an additional 30 percent in future generations of American women provided there is high vaccine coverage in preadolescent girls, continued screening in vaccinated and unvaccinated women, and targeted efforts to recruit and screen women with historically poor access to cervical cancer prevention.

Our findings indicate that it may be worthwhile to consider strategies that differ according to age and vaccination status and to revisit screening options recommended for older women, the authors write.

In an accompanying editorial, Nancy Kiviat, M.D., of Harborview Medical Center in Seattle, and colleagues write The analyses presented [here] will undoubtedly support the urgently needed development of screening recommendations for the immediate future.

Contact:
Article: Robin Herman, rherman@hsph.harvard.edu, (617) 432-4388 or Todd Datz, tdatz@hsph.harvard.edu, (617) 432-3952
Editorial: Nancy Kiviat, nbk@u.washington.edu, (206) 731-3145

Interleukin Plays a Role in Ovarian Cancer Growth

Patients whose tumors produced high levels of interleukin-8 (IL-8) protein had a worse outcome than those with less IL-8. Blocking expression of IL-8 in mouse models of ovarian cancer slowed tumor growth by reducing blood vessel growth.

IL-8 exp
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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