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Other highlights in the Feb. 12 JNCI
Date:2/12/2008

ancer.

Some people with Lynch syndromean inherited condition that predisposes a person to colon cancerare also at greater risk for developing certain skin cancers, a condition known as Muir-Torre syndrome.

Albert de la Chapelle, M.D., Ph.D., and colleagues at The Ohio State University in Columbus investigated how often Lynch syndrome patients were diagnosed with skin tumors related to Muir-Torre syndrome. The study included 152 Lynch syndrome patients from 50 different families.

Fourteen people in the study, each from different families, were diagnosed with Muir-Torre syndrome. Families that carried particular mutations in one of the DNA mismatch repair genes were more likely to have a family member with Muir-Torreassociated skin lesions than those with other mutations in the DNA mismatch repair genes.

On the basis of our results, we suggest that Muir-Torre syndrome be defined as a variant of Lynch syndrome that is characterized by mutations in all [mismatch repair] genes. We propose that Muir-Torre syndromeassociated skin lesions be included as a component tumor of the Lynch syndrome and screened for accordingly, the authors write.

Contact: Eileen Scahill, media relations department, The Ohio State University Medical Center, (614) 293-2092, eileen.scahill@osumc.edu


Reporting of Cancer Drug Side Effects Needs Update

Updated criteria for reporting adverse events in clinical trials are needed, according to a commentary in the Journal of the National Cancer Institute.

The Common Terminology Criteria for Adverse Events was developed by the National Cancer Institute to establish standard language for reporting adverse events that occur in NCI-sponsored clinical trials. Some newer, targeted cancer therapies that are taken daily for an extended period of time often result in side effects, such as diarrhea or nausea. But unde
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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