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Other highlights in the Feb. 12 JNCI
Date:2/12/2008

ular disease is of particular concern to breast cancer patients because of its prevalence and the reality that many therapies for breast cancer can cause cardiac dysfunction, the editorialists write.

Contact:

  • Article: Judith-Anne Chapman, (613) 533-6000 ext. 77390, JChapman@ctg.queensu.ca

  • Editorial: Laura Sussman, press office, M. D. Anderson Cancer Center, (713)745-2457, lsussman@mdanderson.org


    DNA Repair Gene Variant Linked to Brain Cancer Risk

    A certain variation in a DNA repair gene is associated with an increased risk of developing a type of brain cancer called meningioma.

    Meningioma is an uncommon brain tumor that occurs in the meninges, the membranes that cover the brain and spinal cord. Relatives of meningioma patients are at greater risk of developing the cancer, but exposure to radiation also increases ones risk for the disease.

    Richard Houlston, Ph.D., of the Institute of Cancer Research, in Sutton, England, and colleagues investigated whether certain variants in DNA repair genes increased the risk of developing meningioma. They analyzed single-nucleotide polymorphisms (SNPs) in 136 DNA repair genes for their association with meningioma risk.

    A SNP known as rs4968451, which is in a breast cancer susceptibility gene, was associated with increased risk of meningioma. Almost 30 percent of Europeans carry this genetic variant, which, the authors write, could indicate the substantial contribution of the variant in the development of meningioma.

    Contact: Richard Houlston, +44 208 722 4178, richard.houlston@icr.ac.uk


    Skin Cancer and Colon Cancer Syndromes May Be Linked

    A syndrome that increases the risk of some skin cancers may be a subset of a syndrome that increases the risk of colon c
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  • Contact: Liz Savage
    jncimedia@oxfordjournals.org
    301-841-1287
    Journal of the National Cancer Institute
    Source:Eurekalert

    Page: 1 2 3 4

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