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Other highlights in the Dec. 25 JNCI
Date:12/25/2007

mmigrants and 13 cases among second-generation immigrants. The relative risk of testicular cancer was 63 percent lower among first-generation immigrants, but there was no statistically significant difference in risk among second-generation immigrants, compared with men of Danish ancestry.

The difference in testicular cancer rates among men born to foreign parents inside Denmark compared with those immigrating to Denmark as children or adults point to the possibility of environmental influences in utero, the authors write.

Contact: Mads Melbye, co-author, MME@ssi.dk, +45 32 68 31 63


Cannabinoids May Inhibit Cancer Cell Invasion

Cannabinoids may suppress tumor invasion in highly invasive cancers.

Cannabinoids, the active components in marijuana, are used to reduce the side effects of cancer treatment, such as pain, weight loss, and vomiting, but there is increasing evidence that they may also inhibit tumor cell growth. However, the cellular mechanisms behind this are unknown.

Robert Ramer, Ph.D., and Burkhard Hinz, Ph.D., of the University of Rostock in Germany investigated whether and by what mechanism cannabinoids inhibit tumor cell invasion.

Cannabinoids did suppress tumor cell invasion and stimulated the expression of TIMP-1, an inhibitor of a group of enzymes that are involved in tumor cell invasion.

To our knowledge, this is the first report of TIMP-1-dependent anti-invasive effects of cannabinoids. This signaling pathway may play an important role in the antimetastatic action of cannabinoids, whose potential therapeutic benefit in the treatment of highly invasive cancers should be addressed in clinical trials, the authors write.

Contact: Burkhard Hinz, burkhard.hinz@med.uni-rostock.de, +49 381 4945770


Novel Method Used to Classify New vs. Recurrent Can
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Contact: Andrea Widener
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

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