Navigation Links
Osteoporosis drugs compared for side effects, efficacy in Loyola study
Date:12/2/2013

A study comparing the efficacy and tolerability of two popular osteoporosis drugs, denosumab and zoledronic acid, found that denosumab had a significantly greater effect on increasing spine bone mineral density and zoledronic acid caused more flulike symptoms. These findings were presented recently at the American Society for Bone and Mineral Research's annual meeting.

Researchers performed a retrospective chart review and survey of 107 patients to compare the efficacy, patient satisfaction, cost and known adverse effects of denosumab versus zoledronic acid, including muscle pain, back pain and flulike symptoms. The denosumab and zoledronic acid groups were statistically similar in all areas but spine bone mineral density (increased 0.060 g/cm2 versus 0.021 g/cm2, respectively) and flulike symptoms (none versus 29 percent of patients).

"Both groups of patients were satisfied with their treatment despite the discrepancies in the drugs," said Kellen Sheedy, first author and Stritch School of Medicine student.

The FDA approved denosumab in 2010 for postmenopausal women with osteoporosis. It is injected subcutaneously (60 mg) every six months. The treatment works by inhibiting bone loss and fracture risk.

Zoledronic acid was approved by the FDA in 2007 for osteoporosis. This treatment is administered intravenously (5 mg) once every 12 months. It is the most potent of the drugs in its class, and it works by interfering with the bone-breakdown process.

"This study helped us quantify the efficacy and adverse effects of these two drugs providing further guidance for physicians who prescribe these treatments," said Pauline Camacho, MD, study investigator and director of the Osteoporosis & Metabolic Bone Disease Center at Loyola University Health System. "While this was the first head-to-head comparison of these two treatments, larger prospective studies will be needed to confirm these findings."


'/>"/>

Contact: Nora Dudley
nodudley@lumc.edu
708-216-6268
Loyola University Health System
Source:Eurekalert

Page: 1

Related medicine news :

1. Certain Genetic Regions May Be Tied to Osteoporosis
2. Experts recommend men at risk for osteoporosis undergo bone density testing
3. US Drug Watchdog Now Offers To Help Women Who Used TheOsteoporosis Drug Called Fosamax And Then Had A Unexplainable Femur Fracture Get To The Best Attorneys Or Law Firms
4. US Drug Watchdog Now Offers to Help All Woman Who Used Fosamax For Osteoporosis and Then Had an Unexplained a Femur Break Get to the Best Attorneys
5. ASBMR task force urges use of fracture liaision services to reduce costly osteoporosis bone breaks
6. Meeting in Jordan to educate medical professionals on latest advances in osteoporosis
7. Major IOF osteoporosis meeting to take place in Kuala Lumpur, Malaysia
8. Teen Girls Need Bone Health Advice to Stave Off Osteoporosis
9. Has osteoporosis treatment failed when a fracture occurs?
10. Men May Benefit From Osteoporosis Drug, Too: Study
11. Men with belly fat at risk for osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/24/2017)... ... September 25, 2017 , ... Bhowanie Benimadhu’s new book “ Our Creative World: ... life and seeks answers in both Eastern and Western religious traditions and spirituality such ... in the mind of humankind for the past thousands of years and still are,” ...
(Date:9/24/2017)... ... September 24, 2017 , ... Millions of families and businesses worldwide ... wells can provide clean, safe, potable water. However, well water can also become contaminated ... to disease and illness. , The EPA does not regulate private drinking water ...
(Date:9/23/2017)... (PRWEB) , ... September 23, 2017 , ... ... the behavioral approach to fighting obesity of Robert Kushner, director of Chicago’s Center ... weight loss and promoting healthier habits, the article notes that the center routinely ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... they often saves lives. However, if one isn’t accessible in certain locations, the ... of defibrillation, I came up with this idea," said an inventor from Ridgecrest, ...
(Date:9/22/2017)... ... September 22, 2017 , ... SABRE is pleased to ... Molli C., a graduate student from Sonora, California, who will begin her studies ... Thomas University in Miami, Florida, was selected from a pool of more than ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)...  Eli Lilly and Company (NYSE: ... to more efficiently focus resources on developing new ... workforce reductions, including those from a U.S. voluntary ... 3,500 positions. With the streamlining ... approximately $500 million that will begin to be ...
(Date:9/7/2017)... Ind. , Sept. 7, 2017  Zimmer Biomet ... in musculoskeletal healthcare, today announced that it will be ... Global Healthcare Conference at the Grand Hyatt hotel in ... 11, 2017 at 11:40 a.m. Eastern Time. ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
(Date:9/6/2017)... N.Y. , Sept. 6, 2017   PDI , ... announced it will host an educational session focused on ... bloodstream infection (CLABSI) prevention at the 2017 Annual Scientific ... which will take place at the Phoenix ... from Sept. 16-19, will also feature PDI,s ...
Breaking Medicine Technology: