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Osteoporosis drug may help treat advanced hormone-sensitive breast cancer
Date:6/17/2013

fene in a study funded by the drug's manufacturer, Pfizer. First, they applied standard molecular biology techniques to multiple models of human-derived breast cancer cell lines. The models included cancer cells that were resistant to tamoxifen, aromatase inhibitors and lapatinib, a drug used to treat aggressive HER2-positive breast cancer. In all models, bazedoxifene reportedly inhibited estrogen-induced gene expression and cell proliferation.

The researchers then transplanted the cultured breast tumors into immune-compromised mice. Wardell said that bazedoxifene "completely inhibited the estrogen receptor-dependent tumor growth," not only in tumors that had never received tamoxifen treatment but also in those that were resistant to tamoxifen. The drug deterred tumor growth to a similar extent as reported for fulvestrant, she said.

The ideal next research step, according to Wardell, would be a clinical trial to evaluate the efficacy of bazedoxifene in patients with metastatic, hormone therapy-resistant breast cancer.

Pfizer has applied for U.S. Food and Drug Administration approval of bazedoxifene but only when combined with conjugated estrogens for treatment of postmenopausal symptoms and prevention of postmenopausal osteoporosis, she said.


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Contact: Aaron Lohr
alohr@endocrine.org
240-482-1380
The Endocrine Society
Source:Eurekalert

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