Navigation Links
Osteoporosis drug may help treat advanced hormone-sensitive breast cancer

A new osteoporosis drug hinders the growth of estrogen-sensitive cancer that has become resistant to treatment with tamoxifen, a study in mice shows. The results will be presented Saturday at The Endocrine Society's 95th Annual Meeting in San Francisco.

The medication, bazedoxifene, which is approved in Europe under the brand name Conbriza for the treatment and prevention of postmenopausal osteoporosis, also reduced estrogen activity and estrogen receptor levels in cultured human breast cancer cells, the study authors reported.

"Bazedoxifene, a known, safe drug approved in Europe, may present a near-term option as an effective therapy for breast cancer in patients who have relapsed during treatment with tamoxifen or aromatase inhibitors," said Suzanne Wardell, PhD, the study's principal investigator and a research scientist at Duke University, Durham, N.C.

About 70 percent of breast cancers are hormone sensitive, the National Cancer Institute estimates, meaning they need female hormones like estrogen to grow. In one-third to one-half of these patients, the cancer becomes resistant to medications that block either estrogen production or activity of the estrogen receptor, according to Wardell, who said, "These women then have few treatment options."

Treatment options include systemic, or whole-body, chemotherapy or often-painful injections of an anti-estrogen drug, fulvestrant into the buttocks muscle.

The investigators reasoned that one or more drugs known as selective estrogen receptor modulators, or SERMs, might prove effective in treating breast tumors that have developed resistance to hormone blockers. Most SERMs have anti-estrogen effects on some tissues and estrogen-like effects on other tissues. The new SERM bazedoxifene stimulates the estrogen receptor in bone to retain bone mineral density but inhibits estrogen receptor activation in the breast and uterus, Wardell said.

Wardell's team tested bazedoxifene in a study funded by the drug's manufacturer, Pfizer. First, they applied standard molecular biology techniques to multiple models of human-derived breast cancer cell lines. The models included cancer cells that were resistant to tamoxifen, aromatase inhibitors and lapatinib, a drug used to treat aggressive HER2-positive breast cancer. In all models, bazedoxifene reportedly inhibited estrogen-induced gene expression and cell proliferation.

The researchers then transplanted the cultured breast tumors into immune-compromised mice. Wardell said that bazedoxifene "completely inhibited the estrogen receptor-dependent tumor growth," not only in tumors that had never received tamoxifen treatment but also in those that were resistant to tamoxifen. The drug deterred tumor growth to a similar extent as reported for fulvestrant, she said.

The ideal next research step, according to Wardell, would be a clinical trial to evaluate the efficacy of bazedoxifene in patients with metastatic, hormone therapy-resistant breast cancer.

Pfizer has applied for U.S. Food and Drug Administration approval of bazedoxifene but only when combined with conjugated estrogens for treatment of postmenopausal symptoms and prevention of postmenopausal osteoporosis, she said.


Contact: Aaron Lohr
The Endocrine Society

Related medicine news :

1. Simple Ways to Protect Yourself from the Risks of Osteoporosis
2. Nearly 30 percent of women fail to pick up new prescriptions for osteoporosis, study finds
3. Osteoporosis costs EU countries €37 billion every year
4. New scorecard shows inequalities in osteoporosis care in the Europe Union
5. Registration opens for Asia-Pacifics largest medical conference on osteoporosis
6. Smoking and depressive symptoms in adolescent girls are red flag for postmenopausal osteoporosis
7. Are there racial disparities in osteoporosis screening and treatment?
8. Teen smoking decreases bone accumulation in girls, may increase osteoporosis risk
9. Men with belly fat at risk for osteoporosis
10. Men May Benefit From Osteoporosis Drug, Too: Study
11. Has osteoporosis treatment failed when a fracture occurs?
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... International ... UPMC and KingMed Diagnostics researchers. Their review of more ... consultation with UPMC pathologists resulted in significantly altered treatment plans for more than ...
(Date:11/30/2015)... ... November 30, 2015 , ... ”Dying Words: The AIDS Reporting ... on December 1, 2015, to coincide with World AIDS Day. The multi-media project will ... covered the AIDS epidemic as he was dying of the disease. , A collaborative ...
(Date:11/30/2015)... ... November 30, 2015 , ... The Foundation for Breast and ... prevention—is joining forces with the award-winning creator and writer of Downton Abbey Julian ... 2015 at the Union League of Philadelphia. , The benefit, titled “An ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... Ingredients (ASI) as their exclusive channel partner for the Nutraceutical Specialties products into ... in the US, effective immediately. , “We are pleased to announce our ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... Analytics for the last 15 years, announced today that Michigan-based Family Health Center ... of care for over 45 years, FHC was awarded the largest Affordable Care ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Nov. 30, 2015 iCAD, Inc. (Nasdaq: ... feature its latest solutions for advanced image analysis ... cancer at the Radiological Society of North American ... from November 29 to December 4, ... including iReveal®, an automated breast density assessment solution, ...
(Date:11/30/2015)... India , Nov. 30, 2015 Varian Medical Systems ... to develop an educational partnership with Apollo Hospitals Group, the largest ... program that will help train radiation technologists in the country. The ... officer of Apollo Knowledge, and Ashok Kakkar , Varian,s ... . India , Varian intends to ...
(Date:11/30/2015)... KIRKLAND, Wash. , Nov. 30, 2015 /PRNewswire/ ... of Post-Processing services, is pleased to announce a ... of medical imaging services. Building on its ISO-9001:2008 ... adopted and implemented comprehensive Core Lab protocols and ... wide variety of research activities.  Their Core Lab ...
Breaking Medicine Technology: