Navigation Links
Osteoporosis Drugs' Safety Subject of FDA Panel
Date:9/9/2011

solute risk of developing osteonecrosis of the jaw is between 1 in 10,000 and 1 in 400,000 among people taking these drugs for osteoporosis.

But when high-dose bisphosphonates are used to slow the spread of bone cancer, the risk rises, affecting anywhere from 1 percent to 15 percent of patients, she said.

For atypical femur (thigh) fractures, the absolute risk linked to bisphosphonates is about 1 to 5 fractures in 10,000 bisphosphonate users, she said.

Besides hip fractures, bisphosphonates prevent spine, wrist and arm fractures, Shane said.

The FDA wants the committee to consider whether current data support long-term use of bisphosphonates for treating or preventing osteoporosis. The experts also are to consider whether a time limit should be placed on their use, and if patients who need long-term therapy would benefit from a "drug holiday," meaning time off the medication.

"I am really not in favor of putting a limit on use of bisphosphonates and dictating the use of drug holidays," Shane said. "We have very little evidence to support the use of drug holidays or no drug holidays."

If the committee finds that bisphosphonates do pose a serious risk, it may suggest revising the drugs' labels to reflect these potential dangers. The labels already carry a warning about atypical femur fractures.

Dr. Nelson Watts, director of the University of Cincinnati Bone Health and Osteoporosis Center and co-author of a 2010 study on long-term use of bisphosphonates, said length of treatment should be considered on an individual basis. His study suggested patients at mild risk might discontinue drug treatment after five years for as long as no fractures occurred and no bone loss was evident. Higher-risk patients could take the drugs for 10 years and perhaps then take a "holiday" from bisphosphonates of one or two years.

"It would probably be helpful if FDA or some official organization could provide guidelines on duration of tre
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. New study highlights what works in osteoporosis treatment
2. Program announced for 1st Middle-East & Africa Osteoporosis Meeting
3. Preliminary program announced for 2nd Asia-Pacific Osteoporosis & Bone Meeting
4. Gene combinations are found to be related to hip osteoporosis in postmenopausal women
5. Study links long-term use of osteoporosis drugs to unusual fractures
6. An extra 5 years of life an unexpected benefit of osteoporosis treatment
7. Researchers discover age of onset of puberty predicts adult osteoporosis risk
8. Loyola physician helps develop national guidelines for osteoporosis
9. New Osteoporosis Screening Recommendations Issued
10. Belly fat puts women at risk for osteoporosis
11. Taking a break from osteoporosis drugs can protect bones
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Osteoporosis Drugs' Safety Subject of FDA Panel 
(Date:7/23/2014)... PartnerTech Inc. , a major systems integration ... von Uexkull to their facilities, June 6, 2014 as ... a top trade official from the Embassy of Sweden, ... bring awareness and insight to the business community concerning ... , As an expert on global economy, von Uexkull ...
(Date:7/23/2014)... On July 4th, at the age of 70, ... a first place prize in her age group at the Firecracker ... waited until she was in her forties before becoming an ordained ... start running. Not one to do anything halfway, she launched her ... Kitty, the decision to begin running started five years ago at ...
(Date:7/22/2014)... July 22, 2014 Ticket Down ... vs. Manchester City tickets at Sporting Park in Kansas ... on Wednesday, July 23rd. Tickets can be conveniently printed ... Ticket Down can be reached toll free at 1-877-870-3653. ... are authentic and covered by Ticket Down's customer satisfaction guarantee. ...
(Date:7/22/2014)... 23, 2014 Provectus has ... From now on, in addition to working with the ... for Google Glass as well as the creation of ... A dynamic lifestyle requires special gadgets for work, leisure ... found application in healthcare, logistics, travelling, sports, education, science ...
(Date:7/22/2014)... 2014 Obtaining a bachelor’s degree in ... who have hands-on medical experience. The School of Nursing ... announced the launch of an accelerated nursing degree program ... new program, the UNCG Veterans Access Program (VAP), will ... veterans. With some prior college credit, veterans who are ...
Breaking Medicine News(10 mins):Health News:Swedish Official Tours PartnerTech’s U.S. Facility 2Health News:Swedish Official Tours PartnerTech’s U.S. Facility 3Health News:Naperville, Ilinois’ Monarch Landing Resident Wins First Place in 5K Run 2Health News:Sporting Kansas City vs. Manchester City Tickets: Ticket Down Has Slashed Ticket Prices for Manchester City vs. Sporting Kansas City on July 23rd 2Health News:Provectus Announces Development for Google Glass and Wearables 2Health News:UNCG School of Nursing Fast-Tracks Medically Trained Veterans 2
... Epidural hematoma, is a blood clot between the brain and ... Natasha Richardson died from a blunt impact to the head, ... Monday on a beginner,s ski slope in Canada. , The ... hematoma due to blunt impact to the head," said medical ...
... Encourages Dialog between Patients and PhysiciansALEXANDRIA, Va., March 19 ... their end-of-life wishes with their physicians had significantly lower ... found that these conversations between patients and physicians led ... and resulted in a far more peaceful death for ...
... less invasive than deep brain stimulation, researchers say ... with Parkinson,s-like symptoms walked and moved normally again ... frequency electrical currents, a new study shows. , ... has the potential to be an important new ...
... company cofounded by Beth Israel Deaconess Medical Center (BIDMC) ... has announced that it has closed an $8M Series ... Life Sciences (SVLS) and MedImmune Ventures. , The company ... T-cells, with their first program focusing on treatments for ...
... adds features that benefit both patients and health ... a leading international provider of innovative stroke rehabilitation ... www.saebo.com . The new site is designed ... upper extremity stroke rehab products, while making the ...
... of Pittsburgh School of Medicine have begun testing a vaccine ... at high risk for developing the disease. If shown to ... of repeated invasive surveillance tests, such as colonoscopy, that are ... cancer takes years to develop and typically starts with a ...
Cached Medicine News:Health News:Natasha Richardson Died From Head Trauma: Autopsy 2Health News:Natasha Richardson Died From Head Trauma: Autopsy 3Health News:Discussions About End-of-Life Care Reduce Healthcare Costs in Last Week of Life 2Health News:New Parkinson's Treatment Shows Promise in Animals 2Health News:New Parkinson's Treatment Shows Promise in Animals 3Health News:Biotech company cofounded by BIDMC scientists targets natural killer T-cells 2Health News:Saebo Expands Internet Presence With Launch of New Website 2Health News:Saebo Expands Internet Presence With Launch of New Website 3Health News:Pitt vaccine to prevent colon cancer being tested in patients 2
(Date:7/22/2014)... Pa. , July 22, 2014  Eyeon Therapeutics ... dry eye treatment based on a charged hydrophilic polymer ... The product has been shown to be safe and ... Mitchnick , MD, CEO states, "This first set of ... a long way to moving this technology into the ...
(Date:7/22/2014)... , July 22, 2014 Elekta (NSE:EKTAb) and ... that The Christie NHS Foundation Trust ( Manchester, ... a consortium whose mission is to develop the clinical ... radiation therapy system. Such a system would, in principle, ... cancer targets. "The Christie was an ...
(Date:7/22/2014)... SCHOFIELD, Wis. , July 22, 2014 /PRNewswire/ ... and marketer of over-the-counter (OTC) medicinal and healthcare ... corporate sponsor of Operation Troop Aid. ... said Russell Mitchell , CEO and Chairman ... men and women in combat zones experience migraines ...
Breaking Medicine Technology:Particle Sciences and Eyeon Therapeutics Receive Patent on Novel Dry Eye Technology 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 4PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 2PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 3
... best value in high performance electronic pipetting!, ... lightweight design reduce hand fatigue and strain ... tip ejector , Color coding for easy ... for greater performance use Hamilton AdvanTip Low ...
... Research pro Electronic Pipette is ideal for ... Its easy-to-follow display, ergonomically-placed operating buttons, and ... reverse pipetting and diluting make this a ... functions of a manual pipette without any ...
... The Research pro Electronic Pipette is ... the laboratory. Its easy-to-follow display, ergonomically-placed operating ... pipetting, dispensing, reverse pipetting and diluting make ... the simple functions of a manual pipette ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
Medicine Products: