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Osteoporosis Drug Seems to Shrink Breast Tumors
Date:12/11/2008

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  • Finally, aromatase inhibitors may be poised to replace tamoxifen as standard treatment to prevent breast cancer recurrence in women who have already undergone conventional therapy, according to a new meta-analysis. The analysis looked at two groups: women with postmenopausal estrogen receptor-positive breast cancer who took tamoxifen for five years after standard treatment and women who took tamoxifen but then switched to an aromatase inhibitor after initial treatment. "The data are still early but it does show a statistically significant advantage in [women who were switched from tamoxifen to an aromatase inhibitor] but not in [women who took tamoxifen for the full five years]," said Dr. James Ingle, director of the breast cancer program at the Mayo Clinic, in Rochester, Minn. "But you have to remember our experience with tamoxifen. It took 10 to 15 years to see the full effect of tamoxifen."
  • More information

    Visit the U.S. National Cancer Institute for more on breast cancer treatment.



    SOURCES: Dec. 11, 2008, teleconference with Robert Coleman, M.D., professor, medical oncology, University of Sheffield, United Kingdom; Stephen Jones, M.D., medical director, U.S. Oncology Research, Houston; Luca Gianni, M.D., director, medical oncology, National Cancer Institute, Milan, Italy; Stephen Johnston, Ph.D., consultant, medical oncology, and reader, breast cancer medicine, Royal Marsden Hospital and Foundation, United Kingdom; James Ingle, M.D., director, breast cancer program, Mayo Clinic, Rochester, Minn.; Dec. 11, 2008, presentations, CTRC-AACR San Antonio Breast Cancer Symposium, Texas


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