Navigation Links
Osteoporosis Drug Prompts Increase in Certain Bone Cells
Date:12/31/2008

is a dynamic tissue -- it continually remodels and repairs itself," Weinstein explained. "Just like an aircraft wing after many flights gets fatigue damage and needs to be repaired, bone also bears the weight of individuals and undergoes damage and needs repair. There's a system [in which] cells remove the old pockets that are no longer at full capacity and replaces them with new bone.

"This is accomplished by two kinds of cells: armies of osteoclasts that erode cavities in the bone, then teams of osteoblasts which replace old bone with new, strong bone," he continued.

Postmenopausal osteoporosis results from an imbalance in that remodeling process. Fosamax, part of a class of drugs known as bisphosphonates, is thought to prevent that imbalance by decreasing the number of bone-eroding cells.

But, after examining 51 bone biopsy specimens from healthy postmenopausal women (40 to 59 years of age) who had participated in a three-year trial and who took different doses of Fosamax versus a placebo, the study authors found the opposite was actually true.

Women receiving the highest dose of the drug (10 milligrams) once a day had 2.6 times the number of osteoclasts, compared with women in the placebo group. The number of osteoclasts increased with the dose, the study found.

Twenty-seven percent of the osteoclasts were "mega-cells" that were still present one year after the women had stopped taking Fosamax. The study authors hypothesized that bone cells weren't dying, allowing them to fuse together in this way.

"It's like disarming the soldiers in the bone army [osteoclasts] but increasing the size of the army by more than 260 percent," Weinstein said.

"The drugs do work, no question," he said. But, he added, it's important to figure out just how they work (knowledge that often doesn't come until drugs have been in use for a while) to make sure the right people are getting them and to anticipate side ef
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Study Shows Exercise Shields Against Osteoporosis
2. Osteoporosis Drug Seems to Shrink Breast Tumors
3. CT Colonography Screens for Cancer, Osteoporosis
4. CT Colonography Offers One-Stop Screening for Cancer and Osteoporosis
5. CT colonography offers 1-stop screening for cancer and osteoporosis
6. Susan Lark, MD Speaks Out Against the Newest Osteoporosis Drug, Reclast
7. Osteoporosis care at risk in the United States
8. Treating Osteoporosis After Hip Fracture
9. International Osteoporosis Foundation supports UK charity call for NICE guidance changes
10. Repair and healing of osteoporotic fractures a focus of upcoming IOF World Congress on Osteoporosis
11. Osteoporosis Meds Linked to Heart Problem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... August 04, 2015 , ... Rock Your Hair, http://www.rockyourhair.com ... Bash Tour. In addition, they have signed Lexi Noel, dubbed the Teen Beauty Queen ... print and overall branding opportunities for the company. , The Pop & Rock ...
(Date:8/4/2015)... ... ... More than 700 years of marital bliss were celebrated as 13 couples from Friendship ... Kafader and Richard Oas lead the non-denominational service for married couples wishing to reaffirm ... by the Moonlight Serenade Orchestra and a special honeymoon dinner featuring lobster and steak. ...
(Date:8/4/2015)... ... August 04, 2015 , ... Dr. Gary Richter, Montclair ... Favorite Veterinarian. The contest is put on by the American Veterinary Medical Foundation ... Nominees were evaluated on community involvement, ethical behavior, passion for profession, and their ...
(Date:8/4/2015)... ... 04, 2015 , ... The Law Offices of Ben C. Martin , ... with Inferior Vena Cava Filters (“IVC Filters”). , As lead IVC filter lawyer for ... Filter clients under In re Cook Medical, Inc., IVC Filters Marketing, Sales Practices and ...
(Date:8/4/2015)... ... 04, 2015 , ... In the most recent talcum powder ... report that a new location for pretrial proceedings is under consideration, according to ... warning information at their website, the Talcum Powder Cancer Lawsuit Center. , The ...
Breaking Medicine News(10 mins):Health News:Rock Your Hair Signs On As Title Sponsor For The HYPE! Projects Pop & Rock Beauty Bash Tour 2Health News:Couples Renew Vows at Friendship Village of Schaumburg 2Health News:Dr. Gary Richter, Oakland Holistic Veterinarian, Among 20 Finalists for America’s Favorite Veterinarian 2Health News:Dr. Gary Richter, Oakland Holistic Veterinarian, Among 20 Finalists for America’s Favorite Veterinarian 3Health News:Law Offices of Ben C. Martin in Dallas Files New IVC Filter Complications Lawsuits and Pursues Settlements 2Health News:Law Offices of Ben C. Martin in Dallas Files New IVC Filter Complications Lawsuits and Pursues Settlements 3Health News:Talcum Powder Lawsuits: Plaintiffs Suggest Middlesex County Transfer 2Health News:Talcum Powder Lawsuits: Plaintiffs Suggest Middlesex County Transfer 3Health News:Talcum Powder Lawsuits: Plaintiffs Suggest Middlesex County Transfer 4
... across the world is increasing, and it is estimated that over ... will live to see their 100th birthday. According to official estimates,// ... figure of 10,000 to 1.2 million by 2074 in Britain, according ... 30 somethings have a one in eight chance of living to ...
... mode, and milestones are met long before they are due, ... are reaching puberty 18 months sooner than their mothers and 2 ... ,Early puberty is triggered by a range of factors ... most certainly, broken homes, according to the report. Experts have expressed ...
... some food for thought. A component of Cocoa is ... Flavanoids, known to stave off new age diseases like ... according to stalwarts from the food and industry department , ... ,Flavonoids, is found in chocolates, green tea, vegetables and red ...
... Gilead Sciences Inc. has revealed that the results of the ... noticed in the case of those who were taking the ... 10 days on 40 patients. ,The negative ... serious nature. This new therapy is of the integrase inhibitors ...
... York Academy of Sciences, the Chinese Academy of Sciences and ... a unique conference to apprise the world of the progress ... in the light of epidemics like SARS, the H5N1 bird ... ,More than a 100 scientists from China, ...
... Delhi Government to monitor the activity of hospitals after the ... provided by the city’s hospitals //to the poor people. The ... needy segments of society actually benefit from the court's order ... at concessional rates. ,The government has appointed five ...
Cached Medicine News:Health News:Trendsetters: Little girls fast track into ladies even before they know it 2Health News:East And West Meet Under The Aegis of NY Academy Of Sciences' 2
(Date:8/3/2015)... -- Luminex Corporation (NASDAQ: LMNX ) today announced financial ...  Financial and operating highlights for the quarter include the ... by 6 percent to $58.9 million, over the second ... assay revenue by 22 percent to $24.2 million over ... Increased Q2 2015 royalty revenue by 17 percent to ...
(Date:8/3/2015)... MINNEAPOLIS , Aug. 3, 2015 /PRNewswire/ ... a significant shareholder and will become the exclusive ... for cardiology-related diagnostic and monitoring offerings. ... for Preventice Solutions," said Jon Otterstatter , ... Preventice Solutions.  "We are thrilled to partner with ...
(Date:8/3/2015)... (Nasdaq: DRRX ) announced today financial results for the ... net loss was $5.5 million for the three months ended ... million and net loss of $5.5 million for the three ... cash and investments of $37.8 million, compared to cash and ... 30, 2015, we had $19.8 million in long term debt. ...
Breaking Medicine Technology:Luminex Corporation Reports Record 2nd Quarter 2015 Results 2Luminex Corporation Reports Record 2nd Quarter 2015 Results 3Luminex Corporation Reports Record 2nd Quarter 2015 Results 4Luminex Corporation Reports Record 2nd Quarter 2015 Results 5Luminex Corporation Reports Record 2nd Quarter 2015 Results 6Luminex Corporation Reports Record 2nd Quarter 2015 Results 7Luminex Corporation Reports Record 2nd Quarter 2015 Results 8Luminex Corporation Reports Record 2nd Quarter 2015 Results 9Luminex Corporation Reports Record 2nd Quarter 2015 Results 10Luminex Corporation Reports Record 2nd Quarter 2015 Results 11Luminex Corporation Reports Record 2nd Quarter 2015 Results 12Luminex Corporation Reports Record 2nd Quarter 2015 Results 13Luminex Corporation Reports Record 2nd Quarter 2015 Results 14Luminex Corporation Reports Record 2nd Quarter 2015 Results 15Luminex Corporation Reports Record 2nd Quarter 2015 Results 16Boston Scientific Announces Equity Investment And Sales Cooperation Agreement With Preventice Solutions 2DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 2DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 3DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 4DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 5DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 6DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 7DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 8DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 9DURECT Corporation Announces Second Quarter 2015 Financial Results and Update of Programs 10
... Nov. 9, 2010 HeartWare International, Inc. (Nasdaq: ... less invasive, miniaturized circulatory support technologies that are revolutionizing ... Keith Aaronson, MD, MS, will present data from the ... the American Heart Association (AHA) Scientific Sessions 2010 at ...
... 2010 Segal McCambridge Singer & Mahoney, Ltd. and ... in favor of medical device manufacturer I-Flow Corporation.  A ... the District of Oregon returned defense verdicts on all ... three plaintiffs whose cases had been consolidated for trial. ...
Cached Medicine Technology:HeartWare Bridge-to-Transplant Data Featured as Late Breaking Clinical Trial at American Heart Association Scientific Sessions 2010 2
Guaranteed leak-proof , Teflon coating is impervious to corrosive materials , Shock-resistant , NBS tolerances of accuracy , Thermometers are 225 mm long with an immersion length of 35 mm ...
Digital Thermometer & High-Low Temp Alarm, -50C to +90C...
... The F340 is a basic laboratory ... compensated pH results can be obtained when ... a 3-in-1 electrode. • Fast and easy ... buffer recognition for five buffers (pH 1.68, ...
... basic laboratory system for pH and temperature ... obtained when used with a temperature probe ... and easy one and two-point calibration with ... (pH 1.68, 4.00, 7.00, 10.01 and 12.45) ...
Medicine Products: