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Orphan Drugs in Oncology Drug Pipeline Update 2013
Date:11/19/2013

regulator activity
-Ligand-dependent nuclear receptor activity
-Ligase activity
-Lipid kinase activity
-Lipid phosphatase activity
-Metallopeptidase activity
-MHC class I receptor activity
-Molecular function unknown
-Oxidoreductase activity
-Peptide hormone
-Peroxidase activity
-Phosphoric diester hydrolase activity
-Phosphorylase activity
-Protease inhibitor activity
-Protein binding
-Protein serine/threonine kinase activity
-Protein threonine/tyrosine kinase activity
-Protein tyrosine phosphatase activity
-Protein tyrosine/serine/threonine phosphatase activity
-Protein-tyrosine kinase activity
-Receptor activity
-Receptor binding
-Receptor signaling complex scaffold activity
-Receptor signaling protein serine/threonine kinase activity
-RNA binding
-RNA-directed DNA polymerase activity
-Serine-type peptidase activity
-Structural constituent of cytoskeleton
-Superoxide dismutase activity
-T cell receptor activity
-Transcription factor activity
-Transcription regulator activity
-Transferase activity
-Translation regulator activity
-Transmembrane receptor activity
-Transmembrane receptor protein tyrosine kinase activity
-Transporter activity
-Voltage-gated ion channel activity

Sub-Cellular Localization
Identified targets are categorized into 27 different primary and alternate sub-cellular localizations:
-Cell surface
-Centrosome
-Clathrin-coated vesicle
-Cytoplasm
-Cytoplasmic vesicle
-Cytoskeleton
-Cytosol
-Endoplasmic reticulum
-Endosome
-Extracellular
-Golgi apparatus
-Integral to membrane
-Kinetochore
-Lysosome
-Microtubule
-Mitochondrial membrane
-Mitochondrion
-Nuclear
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