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Orphan Drugs in Oncology Drug Pipeline Update 2013
Date:11/19/2013

indications, where of 132 are different cancer indications.

Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets
Mutations
All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 281 out of the 283 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.

Biological Structures
The identity of available biological structures on 208 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 4117 structures available today among drug targets.

Identified drugs are linked to more than 290 different targets, divided into 66 classifications of molecular function:
-Aminopeptidase activity
-ATPase activity
-Auxiliary transport protein activity
-Carboxy-lyase activity
-Catalytic activity
-Cell adhesion molecule activity
-Chaperone activity
-Chemokine activity
-Complement activity
-Cysteine-type peptidase activity
-Cytokine activity
-Deacetylase activity
-Deaminase activity
-DNA binding
-DNA repair protein
-DNA topoisomerase activity
-DNA-directed DNA polymerase activity
-DNA-methyltransferase activity
-Extracellular ligand-gated ion channel activity
-Extracellular matrix structural constituent
-Fucosyltransferase activity
-G-protein coupled receptor activity
-Growth factor activity
-GTPase activity
-Hydrolase activity
-Isomerase activity
-Kinase activity
-Kinase binding
-Kinase
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