Navigation Links
Origin of aggressive ovarian cancer discovered
Date:3/6/2013

marker for stem cells, called ALDH1. They then isolated ALDH1 positive cells, sequenced their genetic profiles and found many markers previously reported for stem cells in other organs.

One of these markers, LGR5, has been studied for intestinal stem cells by other researchers who have bred special mice and developed an advanced method that uses a fluorescent protein to follow stem cells. The gene encoding the fluorescent protein is passed down from a stem cell to each generation of daughter cells, thereby marking the lineage. The technique "allows you to see the fate of stem cells over time," said Nikitin. Using the method on the hilum cells, "we showed that cells from the hilum area spread around the whole ovary."

Finally, the researchers microdissected ovary and hilum cells, inactivated two tumor suppressor genes p53 and Rb1, whose pathways are commonly altered in human aggressive ovarian carcinoma, and injected cells into the abdominal cavity of mice. Very few tumors developed in the mice injected with ovary cells, but almost all of the mice injected with hilum cells died after developing aggressive, metastasizing cancers that were similar to human ovarian carcinomas.

In future work, the researchers will look for stem cells and sources of cancer in transitional zones in the human ovary and other organs, such as the stomach, rectum and uterine cervix.


'/>"/>

Contact: Joe Schwartz
bjs54@cornell.edu
607-254-6235
Cornell University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Bel Marra Health Reports on a New Study: Software Originally Used for Star Gazing Now Being Used to Analyze Breast Cancer Tissue
2. Serious Collector Announces His Search for Original Jimi Hendrix 1968 Independence Hall Baton Rouge, Louisiana Concert Poster
3. EvolutionHealth.com Introduces the the Original Bodylift Yoga Headstand as Used by Martha Stewart, Reverse the Negative Effects of Gravity on the Body
4. Originals By Weber's New Invention: "EZoo" Denture Liner Is Eazy To Put On/Eazy To Take Off Makes Loose Dentures Fit Better
5. Tracking the origins of HIV
6. Massage and the Aboriginal Didgeridoo - A Transcendental Healing Experience in the Heart of New York City
7. Study finds reformulated ER Oxycodone abuse rates are significantly lower than original ER Oxycodone
8. For brain tumors, origins matter
9. Jamaican teen immigrants do better when they retain strong ties to original culture
10. The ORIGIN-GRACE study
11. Stimulant marketed as natural in sports supplement actually of synthetic origin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... 2015 Omar Ahmad Barrada, a junior ... in the 2015 Congress of Future Medical Leaders in ... gathering of “America’s highest achieving high school students.” , ... set new goals and learn better study habits,” said ... during which we can ask the surgeons questions.” , ...
(Date:5/22/2015)... “It’s like learning an new language,” ... President of Clinical Operations/Education and Training at Harmony ... how care is coded and reimbursed.” , Harmony ... reimbursement, operations and compliance consulting, as well as ... a new series of day-long seminars on the ...
(Date:5/22/2015)... May 22, 2015 Coordinating care ... difficult process. Historically providers have not been reimbursed ... Starting in 2015, Medicare has paved the way ... Thanks to the launch of Oculus Health ... health systems using the platform will now be ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Power Systems is ... for the 2015 race season. Drobeck is in his second ... as a firefighter with the Missoula Fire Department in Missoula, ... a Pro in 2014. During his career, he has had ... Pro, Drobeck recorded top 10 finishes in all seven of ...
(Date:5/22/2015)... PA (PRWEB) May 22, 2015 According to ... a hub for drug related death, totaling almost 2,500 confirmed ... as reported by state officials, totals 2,489 deaths stemming from ... work out, Pennsylvania loses seven people every day to fatal ... has been singled out as one of the most rife ...
Breaking Medicine News(10 mins):Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 3Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2
... of Michigan’s researchers has revealed that those children who live in ... put on weight. As many as 16% of those belonging to ... reported to be overweight, while in the UK the number of ... 1990s. ,The researchers, led by Julie Lumeng, looked ...
... strong relationship between obesity and kidney failure. ,The ... develop kidney disease // and the risk for ... ,The link could be because obesity is linked ... renal failure, said author Chi-yuan Hsu, an assistant professor of ...
... Bad habits die hard. Smoking is no exception. To all ... milestone year, here is some mind-blowing news. Smokers // ... in zapping the habit. ,Cold laser therapy, likened to a ... four to five times than that of most other smoking ...
... that the detox tablets taken after the Christmas bash is ... take what is essential and expel the harmful substances. ... and the body automatically recuperates. ,The detox industry ... the flushing out of the toxins from our body. The ...
... The American Society of Clinical Oncology has chosen 11 ... cancer for the year 2005. Prominent// among them is ... recurrence of HER-2-positive early-stage breast cancer. ... early-stage lung cancer is successful if chemotherapy is given ...
... Nearly one in every 10 American teenagers experienced major depression ... to government statistics // . ,Overall, nine percent ... more at risk than their younger peers, said the Substance ... ,The older age bracket (16-17) was more likely to suffer ...
Cached Medicine News:Health News:Surroundings Have An Effect On Weight 2Health News:Study links obesity to kidney failure 2Health News:Zap the butt (cigarette) with Laser Therapy 2Health News:Depression affects one in 10 U.S. teens: study 2
(Date:5/22/2015)... According to a new market ... Instruments, Services), by Test Type (Indirect, Enzyme-based, Reactive Oxygen ... End Users - Global Forecast to 2020", published by ... reach $736.85 Million by 2020 from $452.36 Million in ... Browse 71 market data Tables and 90 Figures ...
(Date:5/22/2015)... 22, 2015 Research and Markets ... the "Latest Regulations on Pharmaceutical International Multi-Center ... offering. This is first time in ... on international multi-center clinical trials of drugs in ... to be implemented on March 1, 2015. The ...
(Date:5/22/2015)... -- Richmond Pharmacology is a university ... worldwide reputation for excellence in clinical trials. It ... reviewed medical journals. Its officers are engaged with ... about rules for transparency and publication of clinical ... Clinical research is conducted worldwide, therefore ...
Breaking Medicine Technology:Oxidative Stress Assays Market Worth $736.85 Million by 2020 2Oxidative Stress Assays Market Worth $736.85 Million by 2020 3Oxidative Stress Assays Market Worth $736.85 Million by 2020 42015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... Oct. 1 Wound Management Technologies, Inc., (OTC Bulletin ... products, announced today it has closed on its acquisition ... technologies including a resorbable bone wax and a delivery ... , Under the terms of the agreement, Resorbable Orthopedics ...
... St. Joseph,s Hospital of Atlanta is the first hospital ... Knife® Perfexion(TM) , an advanced radiosurgery device specifically designed ... making an incision. , A gentler alternative to ... thousands of low-intensity radiation beams to one or more ...
Cached Medicine Technology:Wound Management Technologies Acquires Resorbable Orthopedics 2Wound Management Technologies Acquires Resorbable Orthopedics 3Saint Joseph's Hospital First in Georgia to Offer Noninvasive Treatment of Brain Disorders with Leksell Gamma Knife Perfexion 2Saint Joseph's Hospital First in Georgia to Offer Noninvasive Treatment of Brain Disorders with Leksell Gamma Knife Perfexion 3
C 2.3K with lightweight headband: the practical alternative for spectacle-wearers. Delivered in protective designer case....
... computer operators who require corrective mulitfocal ... different heights and distanced to simulate ... printed two sided- black and white, ... two type sizes to simulate viewing ...
Near PT test card/shorthand /PH stock market 5 1/2 " X 8"...
Near point card 4 1/2 to 24 PT 5 1/2" x 8"....
Medicine Products: