Navigation Links
Origin of aggressive ovarian cancer discovered
Date:3/6/2013

ITHACA, N.Y. Cornell University researchers have discovered a likely origin of epithelial ovarian cancer (ovarian carcinoma), the fifth leading cause of cancer death among women in the United States.

Pinpointing where this cancer originates has been difficult because 70 percent of patients are in advanced stages of disease by the time it is detected. Because the origin of ovarian carcinoma development is unknown, early diagnostic tests have so far been unsuccessful.

Some epithelial cancers are known to occur in transitional zones between two types of epithelium (layers of tissue that line the body and organs and form glands), while others originate in epithelial tissue stem cells. All organs have the capacity for regeneration, which is done by adult stem cells located in areas of each organ called stem cell niches.

With this knowledge, the researchers discovered a novel stem cell niche for the ovarian surface epithelium in mice and showed that ovarian carcinoma preferentially originates from stem cells found in that niche, according to the study published March 6 in the journal Nature. This stem cell niche lies in a transitional area known as the hilum region, a layer of cells that links the ovary to the rest of the body.

"We now know where these cells are located in mice, so we can look in humans in those areas," said Alexander Nikitin, professor of pathology, leader of the Cornell Stem Cell Program and the paper's senior author. Andrea Flesken-Nikitin, a postdoctoral researcher in Nikitin's lab, is the paper's lead author. The findings also provide a guide for scientists to look for stem cell niches and sources of cancer in other transitional zones in other organs, Nikitin added.

The researchers proved that stem cells from the hilum region were highly prone to ovarian carcinoma, using the most current genetic research techniques.

The researchers first found that cells in the hilum region express a known
'/>"/>

Contact: Joe Schwartz
bjs54@cornell.edu
607-254-6235
Cornell University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Bel Marra Health Reports on a New Study: Software Originally Used for Star Gazing Now Being Used to Analyze Breast Cancer Tissue
2. Serious Collector Announces His Search for Original Jimi Hendrix 1968 Independence Hall Baton Rouge, Louisiana Concert Poster
3. EvolutionHealth.com Introduces the the Original Bodylift Yoga Headstand as Used by Martha Stewart, Reverse the Negative Effects of Gravity on the Body
4. Originals By Weber's New Invention: "EZoo" Denture Liner Is Eazy To Put On/Eazy To Take Off Makes Loose Dentures Fit Better
5. Tracking the origins of HIV
6. Massage and the Aboriginal Didgeridoo - A Transcendental Healing Experience in the Heart of New York City
7. Study finds reformulated ER Oxycodone abuse rates are significantly lower than original ER Oxycodone
8. For brain tumors, origins matter
9. Jamaican teen immigrants do better when they retain strong ties to original culture
10. The ORIGIN-GRACE study
11. Stimulant marketed as natural in sports supplement actually of synthetic origin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Principle Business Enterprises, a family ... manufacturing top-of-the-line absorbent products. The company has recently ... popular brand, Tranquility® Premium Protection absorbent products. The ... gave its packaging a new look, and is currently ... to the public. , The new website, developed with ...
(Date:10/20/2014)... October 20, 2014 Rockynol Retirement ... Center on Oct. 14. The $11 million project will ... and a cooked-to-order kitchen with full-service restaurant style dining. ... choice for first class Assisted Living apartments,” said Kara ... deserve the highest quality of care and this investment ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 National Teen Driver ... of the American Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ... in encouraging parents of teen drivers to talk to their ... road. , Motor vehicle crashes are the leading cause of ... drivers involved in fatal crashes, and 859 (42%) of those ...
(Date:10/20/2014)... It’s hard to imagine what it’s like to live without ... world, it’s a reality. And while new shoes are considered ... walk barefoot on rocky terrain or sewage-lined streets just to ... , Buckner International's Shoes for Orphan Souls ... to encourage support for Air1 and while also providing new ...
(Date:10/20/2014)... Spring, Maryland, USA (PRWEB) October 20, 2014 ... or to track interventions? Here comes a wonderful app ... mobile app development company helped its client ... Intervention more efficiently. The app is designed for iOS ... and iPod touch. This app is optimized for iPhone ...
Breaking Medicine News(10 mins):Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3
... administered Sunday to around 2.6 million children below the age ... in Delhi which has reported five polio cases this year. ... Dikshit Saturday expressed concern over the fresh cases but promised ... ,She said the migrant population that arrives in Delhi ...
... reproductive organs from the body of a man who is serving ... also found a uterus and ovaries and removed them. Both these ... R.K. Sharma, the doctor who conducted the operation late Saturday. ... 43 such cases have been found in the world," said Anil ...
... who has been under house arrest since May 2003 in ... regular visits from her personal doctor, United Nations sources said ... Undersecretary General for Political Affairs Ibrahim Gambari, who was granted ... night by Myanmar's ruling junta. ,Gambari, who also ...
... a million packets of fake medicines, most of them from ... according to officials here. ,The fake medicines include ... condoms. A sample that was investigated revealed that what was ... of brick dust. ,"A secret wave of dangerous ...
... in India's northeast living with HIV, the virus that causes ... access to treatment. ,"People are dying regularly and ... because such medicines are very expensive," said Dipak Singh, president ... ,Two MNPP members died earlier this week allegedly due to ...
... who are known for their entrepreneurial skills and its hold ... buying tribal girls// for their inheritance. This issue has caused ... of the main reasons for the fall in female child ... ,Prof Gaurang Jani, senior sociologist associated with the Gujarat ...
Cached Medicine News:Health News:Aung San Suu Kyi complains of irregular medical visits 2Health News:Hundreds dying in northeast from AIDS 2
(Date:10/17/2014)... 2014 Research and Markets  has ... Development Prospect of China Dialysis Market, 2014-2018" ... on the 2013 version, this update Report provides ... industry and the relevant effect in recent three ... segmentations. Moreover, it analyzes Chinese private-owned hemodialysis services. ...
(Date:10/17/2014)... 2014 Investor-Edge has initiated coverage ... ARNA ), NPS Pharmaceuticals Inc. (NASDAQ: ... Momenta Pharmaceuticals Inc. (NASDAQ: MNTA ), and ... these five companies can be accessed at: http://investor-edge.com/register ... 16, 2014, ended on a mixed note as the ...
(Date:10/17/2014)... 17, 2014   InnFocus, Inc ., reported on results ... States for up to 3 years with the ... in Chicago . The Summit ... annual meeting of the American Academy of Ophthalmology . ... 150 glaucoma patients in 6 countries by early 2015. ...
Breaking Medicine Technology:Research and Development Prospect of China Dialysis Market, 2014-2018 2Research and Development Prospect of China Dialysis Market, 2014-2018 3Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 2Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 3Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 4Biotech Equities Technical Briefing - Arena Pharma, NPS Pharma, XOMA, Momenta Pharma, and Catalyst Pharma Partners 5InnFocus Featured at the Ophthalmology Innovation Summit In Chicago 2
... Sept. 27, 2011 Thousands of jobs in Michigan ... if harmful policies – such as imposing new taxes ... by federal policymakers. From research to technical ... suppliers to child care services, the biopharmaceutical sector supports ...
... in Texas supported by the biopharmaceutical research sector would ... new taxes in the Medicare prescription drug program – ... to technical work, manufacturing to construction and other building ... sector supports a broad array of high-quality jobs. ...
Cached Medicine Technology:Research Demonstrates Possible Michigan Job Losses from Sectors Supported by Biopharmaceutical Companies 2Research Demonstrates Possible Michigan Job Losses from Sectors Supported by Biopharmaceutical Companies 3Research Demonstrates Possible Texas Job Losses from Sectors Supported by Biopharmaceutical Companies 2Research Demonstrates Possible Texas Job Losses from Sectors Supported by Biopharmaceutical Companies 3
... unique Model Practice Eye can be used for ... indirect ophthalmoscopy, non-contact fundus biomicroscopy. , ... synthetic rubber which closely resembles the human eye ... of the sclera. The lens and pupil ...
... a cost-effective synthetic bone filler tailored ... Phosphate (TCP) and Hydroxyapatite (HAP), its ... BAB formulates the chemistry and microstructure ... This formulation provides optimal osteo-conduction. The ...
... quadripolar pacing wire design offers ... sensing in the atrium and ... wires in one lead design. ... and ventricle are color-coded for ...
... The TME 227 T is ... for temporary cardiac pacing and ... surgery. The TME 227 T ... the myocardium, which allows safe ...
Medicine Products: