Navigation Links
Orexigen(R) Therapeutics Presents New Data Showing Weight Loss with Contrave Significantly Improves Important Markers of Cardiometabolic Risk
Date:10/24/2009

>Contrave Obesity Research (COR) Trial Design and Safety Profile

All Phase 3 trials in the COR program were 56 week, randomized, double-blind, placebo-controlled trials. The co-primary endpoints were the proportion of patients achieving at least 5% weight loss and percent change in body weight compared to placebo. Secondary endpoints included multiple markers of cardiometabolic risk, patient reported food cravings and eating control measures, as well as HbA1c in the COR-Diabetes trial. Patients were randomized to receive either placebo or Contrave, BID, with a four week titration period.

As previously reported, seven serious adverse events were attributed by investigators as possibly related to Contrave treatment across the entire COR program. These include cholecystitis (gallbladder inflammation), seizure, palpitations, paresthesia and vertigo. The most frequently observed treatment-emergent adverse events were nausea, constipation and headache. Nausea was the leading adverse event resulting in discontinuation; however, for the majority of patients experiencing nausea, it was mild to moderate, transient and manageable.

At week 56, mean blood pressure was generally unchanged from baseline for Contrave patients compared to placebo patients, who tended to experience a slight decrease (approximately 2 mm Hg) from baseline. Contrave treatment did not appear to disrupt the normal circadian pattern of blood pressure. There was a slight increase in pulse (approximately 1 beat per minute) in Contrave patients compared to placebo patients, whose pulse was generally unchanged. There were no meaningful treatment effects on ECGs or laboratory measures including liver function tests. Treatment with Contrave was not associated with increases in symptoms of depression or suicidal ideation.

The Company is on track to submit a New Drug Application (NDA) for Contr
'/>"/>

SOURCE Orexigen Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Orexigen(R) Therapeutics Announces Webcast of Third Quarter Financial Results on November 6, 2008
2. Orexigen(R) Therapeutics to Speak at J.P. Morgan Healthcare Conference
3. Orexigen(R) Therapeutics Names Patrick Mahaffy to Board of Directors
4. Orexigen(R) Therapeutics Names Michael Narachi, 24-Year Biopharmaceutical Veteran, New President and Chief Executive Officer
5. Orexigen(R) Therapeutics Announces In-Licensing of Key Patents to Further Strengthen its Intellectual Property Estate for Contrave(R)
6. Orexigen(R) Therapeutics Announces Proposed Public Offering of Common Stock
7. Orexigen(R) Therapeutics Prices Public Offering of Common Stock
8. Orexigen(R) Therapeutics Announces Second Quarter 2009 Financial Results
9. Orexigen(R) Therapeutics Phase 2b Trial for Empatic(TM) Meets Primary Efficacy Endpoint Demonstrating Significantly Greater Weight Loss Versus Comparators in Obese Patients
10. Prime Therapeutics Receives TIPPS Certification
11. Adams Respiratory Therapeutics to Celebrate 10th Anniversary of its Incorporation on September 12
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... 2015 The Mesothelioma Applied Research ... at the International Symposium on Malignant Mesothelioma on Monday, ... the Hyatt Regency Bethesda in Bethesda, Maryland. The following ... and commitment to the mission to cure mesothelioma. , ... be presented to Miriam Ratner. Miriam runs the Meso ...
(Date:2/28/2015)... Beach, CA (PRWEB) February 28, 2015 ... needs of Central Coast area residents, recently announced a ... System. It’s a treatment option for new and ... kick off 2015 with a bright, white smile, Dr. ... discounted price of $299, marked down from the regular ...
(Date:2/28/2015)... Kaylie Corrigan, Outdoor Supervisor at Back2Basics ... current student obtaining her Masters degree in social work ... in psychoeducation on substance use for teens at the ... of her studies. , “Even though these students are ... at the high school and junior high school level,” ...
(Date:2/28/2015)... February 28, 2015 The noted Friedman ... that they have officially relaunched their website. The new ... but it contains a new section about their team ... read the full biographies of each Friedman Dental Group ... the website was designed to provide our patients with ...
(Date:2/28/2015)... Janesville, WI (PRWEB) February 28, 2015 ... The designation recognizes Mercy Harvard Hospital as stroke capable ... to be brought via ambulance to Mercy Harvard Hospital. ... the state to indicate their ability to treat stroke ... The designation allows ambulances transporting stroke patients to bypass ...
Breaking Medicine News(10 mins):Health News:Cancer Research Foundation Honors Award Recipients 2Health News:Cancer Research Foundation Honors Award Recipients 3Health News:Cancer Research Foundation Honors Award Recipients 4Health News:Pismo Beach Dentist Announces Special for Zoom! Teeth Whitening 2Health News:Staff at Arizona Drug Addiction Treatment Center Starts Teen Sobriety Support Group at Local High School 2Health News:Friedman Dental Group Announces Their Updated Website 2Health News:Mercy Harvard Hospital Recognized as Leader in Stroke Care - Javon Bea 2
... of East Anglia,s Climatic Research Unit (CRU) are leaked on the ... calls for a debate into science and transparency. , Emails were ... ,Information Gap, leading science writer Fred Pearce argues that ,if CRU ... great deal of time and angst on the part of its ...
... Cambridge, Mass. November 30, 2011 From targeted ... the 21st century may prove to be the age ... though, will be miniscule. Experts in chemistry, applied ... week for the BASF Advanced Research Initiative at Harvard ...
... creatures on Earth have skin that produces the greatest ... becoming new weapons in the battle against antibiotic-resistant infections, ... (like rotten fish, for instance) that scientists term them ... Research . Yun Zhang, Wen-Hui Lee and Xinwang ...
... -- There may be a link between high blood sugar ... women, a new study finds. Researchers analyzed 12 years ... Women,s Health Initiative study. The women,s fasting blood sugar (glucose) ... study and then several more times over the next dozen ...
... have a financial interest in imaging equipment are more ... exams, according to a study presented today at the ... (RSNA). "Self-referral," whereby a non-radiologist physician orders ... which that physician has a financial interest, is a ...
... HealthDay Reporter , TUESDAY, Nov. 29 (HealthDay News) ... In a 12-month study of 123 overweight or obese women, ... than those who skipped a mid-morning nosh. The finding ... the short interval between breakfast and lunch for these snackers, ...
Cached Medicine News:Health News:Is transparency bad for science? 2Health News:Nano meets pharma at Harvard-BASF symposium 2Health News:Nano meets pharma at Harvard-BASF symposium 3Health News:Women's High Blood Sugar Linked to Colorectal Cancer: Study 2Health News:Self-referral leads to more negative exams for patients 2Health News:Mid-Morning Snacks May Thwart Diets 2Health News:Mid-Morning Snacks May Thwart Diets 3
(Date:2/27/2015)...  Organovo Holdings, Inc. (NYSE MKT: ONVO) ("Organovo"), ... 3D bioprinting technology, announced today that Keith ... present live at VirtualInvestorConferences.com on March 5th. ... for this Company update," said Mr. Murphy. "We ... of the exVive3D Liver, Bioprinted Human Tissue, commercialization ...
(Date:2/27/2015)... YORK , Feb. 27, 2015 /PRNewswire/ ... are increasing in applications as their effectiveness ... firm Kalorama Information.  Kalorama Information says that ... is the most powerful tool in proteomic ... spec; MS) through its traditional techniques has ...
(Date:2/26/2015)... , Feb. 26, 2015  Today the National ... The psychological and physical side effects of pain medications ... painkillers, such as Vicodin and Oxycontin, are safer options ... overdose on prescription painkillers than on heroin and cocaine ... CEO of NSC. "Yet, these medications are marketed as ...
Breaking Medicine Technology:Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 2Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 3Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 4Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3National Safety Council: Opioid prescription painkillers have hidden, deadly side effects 2
... Eli Lilly and Company (NYSE: LLY ) will announce its ... 2010 .  Lilly will also conduct a conference call on that day with ... , , , ... from 9:00 a.m. to 10:00 a.m. EDT .  Investors, media and the ...
... RALEIGH, N.C. , July 9 Pioneer Surgical Technology, ... technical biologic expertise to support their growing line of products that address ... , , ... stated, "We are extremely pleased with our ability to provide innovative biologic ...
Cached Medicine Technology:Lilly Confirms Date and Conference Call for Second-Quarter 2010 Financial Results Announcement 2Pioneer® Surgical Expands Product Specialists to Support Growing Biologics Business 2
... Deluxe specimen bath mounts inside the existing black ... for the separation of buffer and ice kept ... can be sterilized and has round mounting disks ... The disks and bath surface are marked ...
Punch set for Advanced Tissue Arrayer, 1.5 mm...
Inquire...
Inquire...
Medicine Products: