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Orexigen(R) Therapeutics Presents New Data Showing Weight Loss with Contrave Significantly Improves Important Markers of Cardiometabolic Risk
Date:10/24/2009

------- COR-I COR-II ----- ------ PBO Contrave32 PBO Contrave32 --- ---------- --- ---------- Waist Circumference -2.8 -7.1* -2.2 -7.3* (cm) (N=282) (N=279) (N=254) (N=410) Males >102 cm Females >88 cm Fasting Triglycerides -32.0 -66.3* -13.9 -51.2* (mg/dL) (N=82) (N=87) (N=69) (N=135) >/=150 mg/dL Fasting HDL +1.3 +5.0* +1.3 +6.2* (mg/dL) (N=122) (N=121) (N=117) (N=184) Males <40 Females <50 Fasting LDL (mg/dL) -22.5 -12.8 -8.0 -27.3 >/=160 mg/dL (N=29) (N=31) (N=26) (N=44) hsCRP (mg/L) -0.7 -2.9* -1.1 -1.6* >3 mg/L (N=163) (N=177) (N=144) (N=261) *p<.05 for difference between Contrave and placebo

"The focus of today's panel discussion on pharmacotherapy among distinguished members of the scientific community serves as further validation that medication may play an important role in the treatment of obesity," said Eduardo Dunayevich, M.D., Chief Medical Officer, Orexigen Therapeutics. "We believe that, if approved, Contrave can benefit a broad range of obese patients. The results of the COR program, coupled with recently disclosed results from our Empatic Phase 2b trial, support our belief that these two product candidates can help fill the current gap in obesity treatment by providing physicians with multiple pharmacologic options to address the varying needs of this diverse patient population."

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SOURCE Orexigen Therapeutics, Inc.
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4. Orexigen(R) Therapeutics Names Michael Narachi, 24-Year Biopharmaceutical Veteran, New President and Chief Executive Officer
5. Orexigen(R) Therapeutics Announces In-Licensing of Key Patents to Further Strengthen its Intellectual Property Estate for Contrave(R)
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