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Orexigen(R) Therapeutics Presents New Data Showing Weight Loss with Contrave Significantly Improves Important Markers of Cardiometabolic Risk
Date:10/24/2009

m baseline."

Additional findings presented today from patients who completed 56-weeks of therapy include:

    Efficacy Results
    ----------------
                                   COR-I                       COR-II
                                   -----                       ------
                              PBO        Contrave32       PBO       Contrave32
                            (N=290)       (N=296)       (N=267)      (N=434)
                            ------         ------        ------       ------

    Equal or greater
    than 5% weight
    loss (%)                 23.1%        61.8%*         21.7%      75.8%*

    Equal or Greater
    than 10%
    weight loss (%)          10.7%        34.5%*          7.9%      48.2%*

    Equal or Greater
    than 15%
    weight loss (%)           3.1%        17.2%*          3.4%      23.0%*


    Markers of Cardiometabolic Risk (mean change)
    ---------------------------------------------
                                    COR-I                       COR-II
                                    -----                       ------
                              PBO        Contrave32       PBO       Contrave32
                            (N=290)       (N=296)        (N=267)      (N=434)
                            ------         ------        ------       ------
    Waist
    circumference
    (cm)                     -2.7         -6.9*          -2.1       -7.1*

    Fasting
    triglycerides
    (mg/dL)                  -3.8        -19.0*          +0.5      -14.8*

    Fasting HDL
    (mg/dL)                  -0.1         +3.5*          -1.0       +4.2*

    Fasting LDL
     (mg/dL)                 -2.8         -4.3           -2.0       -6.3*

    hsCRP (mg/L)             -0.5         -1.6*           0.0       -0.7*


    Markers of Cardiometabolic Risk (mean change among patients with increased
    cardiometabolic risk)
    -------------------------------------------------------------------
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SOURCE Orexigen Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

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Related medicine news :

1. Orexigen(R) Therapeutics Announces Webcast of Third Quarter Financial Results on November 6, 2008
2. Orexigen(R) Therapeutics to Speak at J.P. Morgan Healthcare Conference
3. Orexigen(R) Therapeutics Names Patrick Mahaffy to Board of Directors
4. Orexigen(R) Therapeutics Names Michael Narachi, 24-Year Biopharmaceutical Veteran, New President and Chief Executive Officer
5. Orexigen(R) Therapeutics Announces In-Licensing of Key Patents to Further Strengthen its Intellectual Property Estate for Contrave(R)
6. Orexigen(R) Therapeutics Announces Proposed Public Offering of Common Stock
7. Orexigen(R) Therapeutics Prices Public Offering of Common Stock
8. Orexigen(R) Therapeutics Announces Second Quarter 2009 Financial Results
9. Orexigen(R) Therapeutics Phase 2b Trial for Empatic(TM) Meets Primary Efficacy Endpoint Demonstrating Significantly Greater Weight Loss Versus Comparators in Obese Patients
10. Prime Therapeutics Receives TIPPS Certification
11. Adams Respiratory Therapeutics to Celebrate 10th Anniversary of its Incorporation on September 12
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