Navigation Links
Oregon researchers find trigger gene for muscle development
Date:1/31/2008

University of Oregon scientists say they have identified a gene that is the key switch that allows embryonic cells to form into muscles in zebrafish.

Much like students in a kindergarten class lining up to go to lunch, the trigger gene, which is identified as Smarcd3, must align correctly with two other genes for muscle formation to begin, a process known as myogenesis, said principal investigator Monte Westerfield, a professor of biology and researcher in the UO Institute of Neuroscience.

The basic research, funded by the National Institutes of Health, was done using zebrafish embryos, which provide a model system for analyzing the genetic control of induction and specification of muscle cells in vertebrates, as well as for many other important health issues. The findings were published online ahead of the regular publication by the Journal of Biological Chemistry.

"Our muscles develop from a particular set of cells in the embryo," Westerfield said. "These muscle precursor cells need to be in the right place at the right time to develop into muscles. Previously it was unknown how the timing of this critical developmental switch is controlled. We discovered the missing factor, Smarcd3, which forms a protein complex that alters the shape of DNA in particular regions of the genome, thus turning on genes required for cells to develop into muscle."

Smarcd3 proteins are part of a chromatin-remodeling complex made up of DNA and proteins that make up chromosomes. It is a transcriptional protein, which means it is important for initiating, in this case, development.

The UO researchers found that muscle formation begins in an embryo's mesoderm when Smarcd3 interacts correctly with two other transcription-factors known as Fgf and Ntl. This specific time-sensitive alignment, the researchers noted, works to trigger the earliest gene expression involved in myogenesis.

Previous research had suggested the requirement
'/>"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. TriWest Contributes $30,000 to Oregon National Guard Fund
2. Tobacco Industry Puts Profits Before Kids in Defeating Oregon Ballot Initiative
3. Big Tobacco Spends Record $12 Million to Deceive Oregon Voters
4. New Report: Increasing Oregons Cigarette Tax Will Reduce Smoking, Save Lives and Save Money
5. The First Mega-Shelter Arrangement in Oregon Created for Major Disaster Response and Recovery
6. Details of Oregon Wine Regions First Luxury Inn, Spa Revealed at Groundbreaking Ceremony
7. Big Tobaccos Latest Dirty Trick: Deceiving Oregon Voters
8. Oregon Scientific to Sponsor First-Ever Rock Concert on Mount Everest
9. Contents of the McGinnis Mansion Refurbishes Portland, Oregon Sexual Minority Youth Center
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. Researchers uncover more about how poxviruses evade the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oregon researchers find trigger gene for muscle development
(Date:5/24/2013)... (HealthDay News) -- Patients hospitalized for heart failure appear ... on Mondays or in the morning, a new study ... highest among heart failure patients admitted in January, on ... scheduled to present their findings Saturday in Portugal at ... the European Society of Cardiology. "The fact ...
(Date:5/24/2013)... KC and Monica Craichy, Founders of ... Their oldest sons, Kyle and Austin Craichy, will be kiteboarding ... several professional kiteboarders. , KC Craichy said he is excited ... come together such that virtually everyone who planned to be ... kite boarders will meet at Matheson Hammock Park and Beach ...
(Date:5/24/2013)... 24 (HealthDay News) -- New research suggests a ... people with insomnia. Every additional hour someone ... percent drop in the likelihood of moderate or ... the University of Pennsylvania. "We were ... sleep duration and suicide risk," study author, Linden ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Gift ... Cards, major competitors in sustainable card material, are ... using forest materials as a sustainable gift card ... to identify industry challenges and increase education and ... programs to support the reduction of carbon footprint ...
(Date:5/24/2013)... Let’s face it: very few are luckily gifted ... majority of people to be uncomfortable with the color of ... addiction or simply genetics, yellowish or stained teeth suppresses confidence ... , Herald Square Dental is proud to announce the ... White Max. , Teeth become discolored for a number ...
Breaking Medicine News(10 mins):Health News:Monday Best Time for Hospitalization With Heart Failure, Study Says 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:Sleep Duration Linked to Suicidal Thoughts in People With Insomnia 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 3Health News:Herald Square Dental Introduces New In-office Whitening System: Venus White Max 2
... A study of H1N1 and seasonal influenza vaccination in a ... low rate of vaccine acceptance among parents and caregivers. Only ... children against H1N1, and 22 percent indicated their children ... The majority of children in the sample (71 percent) were ...
... Goodwin HealthDay Reporter , THURSDAY, April 28 ... fill out while waiting to see their child,s ... suggests. Researchers recruited 137 pediatricians in the San ... screening test to fill out before seeing the doctor. ...
... tube defects in neonates are common in Germany compared with ... in Germany might prevent these in 85-100% of cases, Wolfgang ... Deutsches rzteblatt International (Dtsch Arztebl Int 2011; 108[15]; 249-54). ... pregnancy ensures that the fetus does not develop the neural ...
... This release is available in French and ... researchers have proven that melatonin a natural hormone produced by ... the intake of food, improves blood lipid profile as it ... Melatonin is found in small quantities in some fruits and ...
... HealthDay Reporter , WEDNESDAY, April 27 (HealthDay News) -- The ... a new claim to fame: leprosy. A new ... and have somehow passed the disease to several dozen humans ... long-suspected link between leprosy in humans and armadillos," said the ...
... HealthDay Reporter , THURSDAY, April 28 (HealthDay News) -- ... see their cancer risk drop to normal after three "all ... can then resume screening for cervical cancer on the same ... is how we should follow women who have been treated ...
Cached Medicine News:Health News:Pediatric flu vaccination: Understanding low acceptance rates could help increase coverage 2Health News:Quick Screening May Help Spot Autism in Babies 2Health News:Quick Screening May Help Spot Autism in Babies 3Health News:Melatonin might help in controlling weight gain and preventing heart diseases associated with obesity 2Health News:Armadillos Give Leprosy to Humans in Southern U.S.: Study 2Health News:Armadillos Give Leprosy to Humans in Southern U.S.: Study 3Health News:After Treatment for Precancerous Cervical Lesions, Risk Drops to Normal for Some 2Health News:After Treatment for Precancerous Cervical Lesions, Risk Drops to Normal for Some 3
(Date:5/23/2013)... -- A recently published clinical study conducted at TOPS Comprehensive ... demonstrates that 3D mammography (breast tomosynthesis) significantly reduces unnecessary ... The study, "Implementation of Breast Tomosynthesis in a Routine ... Stephen L. Rose , MD, and published ... of Roentgenology (AJR). The AJR is the scientific ...
(Date:5/23/2013)...  The need to add tissue preserving therapies ... prominently at the 108 th Annual Meeting ... Diego.  According to SonaCare Medical, a leader in ... the need for image-guided technologies to better identify ... minimally invasive ablative treatments, was addressed in the ...
(Date:5/23/2013)... Mass. , May 23, 2013  Hologic, ... HOLX ), a leading developer, manufacturer and supplier ... products, with an emphasis on serving the healthcare ... large-scale observational study in a U.S. clinical practice ... technology (breast tomosynthesis) with conventional 2D mammography alone ...
Breaking Medicine Technology:First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 2First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... order tips. Each box contains 10,000 tips ... in easy-to-open, re-sealable Bulk Packs of 200 ... with a tamper-proof strip which can easily ... Diamond Tips. Bulk Packs are closed using ...
Capillary section fits into a 0.3-mm well for accurate loading of sequencing gels - Ideal for use with CastAway System...
This extended 10 ul combats contamination by keeping your pipettor out of 1.5 ul and 2.0 ul tubes. Utilizes MicroPoint design and 2 ul reference mark....
... powerful motor with a lightweight, comfortable design. ... three positions for maximum comfort and convenience.mum ... button on the top of the filler ... wide-angle position is ideal for restricted spaces ...
Medicine Products: