Navigation Links
Oregon researchers find trigger gene for muscle development
Date:1/31/2008

University of Oregon scientists say they have identified a gene that is the key switch that allows embryonic cells to form into muscles in zebrafish.

Much like students in a kindergarten class lining up to go to lunch, the trigger gene, which is identified as Smarcd3, must align correctly with two other genes for muscle formation to begin, a process known as myogenesis, said principal investigator Monte Westerfield, a professor of biology and researcher in the UO Institute of Neuroscience.

The basic research, funded by the National Institutes of Health, was done using zebrafish embryos, which provide a model system for analyzing the genetic control of induction and specification of muscle cells in vertebrates, as well as for many other important health issues. The findings were published online ahead of the regular publication by the Journal of Biological Chemistry.

"Our muscles develop from a particular set of cells in the embryo," Westerfield said. "These muscle precursor cells need to be in the right place at the right time to develop into muscles. Previously it was unknown how the timing of this critical developmental switch is controlled. We discovered the missing factor, Smarcd3, which forms a protein complex that alters the shape of DNA in particular regions of the genome, thus turning on genes required for cells to develop into muscle."

Smarcd3 proteins are part of a chromatin-remodeling complex made up of DNA and proteins that make up chromosomes. It is a transcriptional protein, which means it is important for initiating, in this case, development.

The UO researchers found that muscle formation begins in an embryo's mesoderm when Smarcd3 interacts correctly with two other transcription-factors known as Fgf and Ntl. This specific time-sensitive alignment, the researchers noted, works to trigger the earliest gene expression involved in myogenesis.

Previous research had suggested the requirement of several additional transcription proteins, but the UO team was able to sort through many of the combinations and narrow the field to these three factors. The findings could eventually allow researchers to understand how various combinations of proteins in the chromatin act to regulate the development of different cell types, tissues and organs.


'/>"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert  

Related medicine news :

1. TriWest Contributes $30,000 to Oregon National Guard Fund
2. Tobacco Industry Puts Profits Before Kids in Defeating Oregon Ballot Initiative
3. Big Tobacco Spends Record $12 Million to Deceive Oregon Voters
4. New Report: Increasing Oregons Cigarette Tax Will Reduce Smoking, Save Lives and Save Money
5. The First Mega-Shelter Arrangement in Oregon Created for Major Disaster Response and Recovery
6. Details of Oregon Wine Regions First Luxury Inn, Spa Revealed at Groundbreaking Ceremony
7. Big Tobaccos Latest Dirty Trick: Deceiving Oregon Voters
8. Oregon Scientific to Sponsor First-Ever Rock Concert on Mount Everest
9. Contents of the McGinnis Mansion Refurbishes Portland, Oregon Sexual Minority Youth Center
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. Researchers uncover more about how poxviruses evade the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oregon researchers find trigger gene for muscle development
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... "FCPX editors ... customizable inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... style. Final Cut Pro X users can now reveal the media of ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... Birmingham, Lake Orion, Clarkston, Michigan (PRWEB) , ... ... ... their direction with respect to fertility once they have been diagnosed with endometriosis. ... for tolerable intercourse but they also require a comprehensive approach that can help ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ANDOVER, Mass. and SAN CLEMENTE, Calif. ... California -based mobile pulmonary function testing company, is now ... portable PFT devices developed by ndd Medical Technologies , Inc. ... PFT testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ... CA , can get any needed testing done in the ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology: