Navigation Links
Ordinary heart cells become 'biological pacemakers' with injection of a single gene
Date:12/16/2012

LOS ANGELES (EMBARGOED UNTIL DEC. 16, 2012 AT 1 P.M. EST) Cedars-Sinai Heart Institute researchers have reprogrammed ordinary heart cells to become exact replicas of highly specialized pacemaker cells by injecting a single gene (Tbx18)a major step forward in the decade-long search for a biological therapy to correct erratic and failing heartbeats.

The advance will be published in the Jan 8 issue of Nature Biotechnology and also will be available today on the journal's website.

"Although we and others have created primitive biological pacemakers before, this study is the first to show that a single gene can direct the conversion of heart muscle cells to genuine pacemaker cells. The new cells generated electrical impulses spontaneously and were indistinguishable from native pacemaker cells," said Hee Cheol Cho, PhD., a Heart Institute research scientist.

Pacemaker cells generate electrical activity that spreads to other heart cells in an orderly pattern to create rhythmic muscle contractions. If these cells go awry, the heart pumps erratically at best; patients healthy enough to undergo surgery often look to an electronic pacemaker as the only option for survival.

The heartbeat originates in the sinoatrial node (SAN) of the heart's right upper chamber, where pacemaker cells are clustered. Of the heart's 10 billion cells, fewer than 10,000 are pacemaker cells, often referred to as SAN cells. Once reprogrammed by the Tbx18 gene, the newly created pacemaker cells "induced SAN cells" or iSAN cells had all key features of native pacemakers and maintained their SAN-like characteristics even after the effects of the Tbx18 gene had faded.

But the Cedars-Sinai researchers, employing a virus engineered to carry a single gene (Tbx18) that plays a key role in embryonic pacemaker cell development, directly reprogrammed heart muscle cells (cardiomyocytes) to specialized pacemaker cells. The new cells took on the dis
'/>"/>

Contact: Sally Stewart
sally.stewart@cshs.org
310-248-6566
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Citizen science more than a century later: Ordinary people go online to track Gulf oil spill
2. Ordinary chickens may be extraordinary in fighting cancer, says Texas A&M researcher
3. Carriers of gene variant appear less likely to develop heart disease
4. Yo-Yo Dieting Can Hurt the Heart, Study Finds
5. Stop-Smoking Drug Chantix May Carry Heart Risks, FDA Warns
6. U.S. Lifestyles Thwarting Heart Health Progress: Report
7. Fainting in Healthy People May Be First Sign of Heart Trouble
8. Massage and the Aboriginal Didgeridoo - A Transcendental Healing Experience in the Heart of New York City
9. Even Light Smoking Boosts Womens Risk of Sudden Heart Death: Study
10. Common Heart Drug Might Dampen Some Autism Symptoms
11. A Single Pill for Heart Disease Prevention? from the December 2012 Harvard Women's Health Watch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... April 18, 2015 More than 2000 ... now at TheCelebrityDresses.com, the #1 online store carrying celebrity ... many girls have got their perfect dresses for their ... celebrity fashion prom dresses at TheCelebrityDresses.com would be an ... more than 2000 prom dresses inspired by the most ...
(Date:4/18/2015)... York, NY (PRWEB) April 18, 2015 On ... Internal Security Threat Report , which they say, “exposes a ... how many new malware variants were introduced in 2014 - ... took for Zero Day threats to be identified and patched ... it is abundantly clear that doing business in a digital ...
(Date:4/18/2015)... 18, 2015 Aureus Medical Group ... including physical therapy jobs, has announced that it ... Carolina Physical Therapy Association Annual Conference to be ... in Greenville, SC. , The SCAPTA Annual ... with products and services. , Representatives from ...
(Date:4/18/2015)... ” was featured on NewsWatch as part of its monthly ... applications on the market for iOS, Android, and ... conducted the app review and shared with viewers how this ... world, people may find themselves in dangerous situations where they ... but some situations can be avoided if there was an ...
(Date:4/18/2015)... April 18, 2015 PHOENIX, ARIZONA – ... along with 11 other secure destruction professionals across the ... Specialists (CSDS). He will now display “CSDS” as a ... offered before the National Association of Information Destruction 2015 ... another Grapevine, Texas. Of the 20 people who took ...
Breaking Medicine News(10 mins):Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:A Personal Safety Application was Featured on NewsWatch Television 2
... RAISE AWARENESS THAT ADDICTION IS A,CHRONIC, TREATABLE DISEASE ... A PUBLIC RALLY IN NYC ON SEPTEMBER 27TH, ... 16 A&E Network today announced the,launch of ... help raise awareness that addiction is a treatable ...
... UNION COUNTY, Pa., Sept. 16 The ... Pennsylvania, is one,of the first recipients of ... FOUND was developed to counter the rise ... Project Lifesaver is a nationwide tracking program ...
... to diagnose location of defects, study says , , ... contribute to hearing loss in children can be detected ... records of hundreds of children diagnosed with sensorineural (related ... computed tomography (CT) and X-rays, is often used to ...
... Food and Drug Administration (FDA), Scott Mandell, CEO, President ... manufacturer of allergy-friendly and gluten-free foods, provided comments at ... of allergens in foods. Mandell cautioned that current labeling ... and other special diet consumers. , ...
... issue campaign aimed,at strengthening and reauthorizing the State Children,s ... Health Care for,Kids, a new, non-partisan organization of labor ... assure that every American child gets,the high quality health ... Kids has launched a bipartisan TV and direct mail,campaign ...
... September 16, 2008 Studies published in a special issue ... Policy by the University of California Press reveal ... behavior in teenagers, provide inaccurate information about condoms, and ... MD, MPH, professor and chair of the Heilbrunn Department ...
Cached Medicine News:Health News:A&E Network Partners with Leading Federal Agencies and Non-Profit Organizations To Launch The Recovery Project 2Health News:A&E Network Partners with Leading Federal Agencies and Non-Profit Organizations To Launch The Recovery Project 3Health News:National Autism Association's 'FOUND' Provides Funds to Union County Sheriff's Office for Project Lifesaver Equipment 2Health News:MRI Detects Soft Tissue Damage Affecting Kids' Hearing 2Health News: Enjoy Life Foods CEO Tells FDA Grocery Stores Remain A Dangerous Minefield for Food Allergic, Food Intolerant and Celiac Shoppers 2Health News: Enjoy Life Foods CEO Tells FDA Grocery Stores Remain A Dangerous Minefield for Food Allergic, Food Intolerant and Celiac Shoppers 3Health News: Enjoy Life Foods CEO Tells FDA Grocery Stores Remain A Dangerous Minefield for Food Allergic, Food Intolerant and Celiac Shoppers 4Health News:Multi-million Dollar Campaign for Kids' Health Program is Launched 2Health News:Multi-million Dollar Campaign for Kids' Health Program is Launched 3Health News:Accuracy, efficacy and ethics of abstinence-only programs questioned by public health experts 2Health News:Accuracy, efficacy and ethics of abstinence-only programs questioned by public health experts 3Health News:Accuracy, efficacy and ethics of abstinence-only programs questioned by public health experts 4
(Date:4/17/2015)... 2015 Research and Markets ( ... "The Corporate Reputation of Pharma - The ... report to their offering. The ... now in its fourth edition. This report contains ... For each annual Corporate Reputation report, the author ...
(Date:4/17/2015)... April 17, 2015 Bionomics Limited (ASX:BNO, ADR:BMICY), ... of innovative therapeutics for the treatment of cancer and ... presentation of data from three of its most advanced ... Research (AACR) 106 th Annual Meeting being held ... USA. The presentation on ...
(Date:4/16/2015)... , April 16, 2015 Mindray ... developer, manufacturer, and marketer of medical devices worldwide, ... Securities and Exchange Commission an Annual Report on Form ... year ended December 31, 2014. An electronic version of ... on Mindray,s investor relations website at  http://ir.mindray.com  or  ...
Breaking Medicine Technology:The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2
... Alcon, Inc. (NYSE: ACL ) and its ... today that Alcon has begun treating patients in a Phase ... for viral conjunctivitis, a type of "pink eye". Conjunctivitis ... and children, leading to more than four million doctor and ...
... and BRISTOL, Tenn., July 2 Acura Pharmaceuticals, Inc. (Nasdaq: ... KG ) announced today that the U.S. Food and ... the New Drug Application (NDA) for Acurox (oxycodone HC1, USP ... for the relief of moderate-to-severe pain. , ...
Cached Medicine Technology:Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis 2Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis 3Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis 4Acura and King Receive FDA Complete Response Letter Regarding Acurox(R) 2Acura and King Receive FDA Complete Response Letter Regarding Acurox(R) 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: