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Oral contraceptives and hormone replacement therapy may protect women against brain aneurysms
Date:7/30/2010

ysm incidence. Both groups were screened with questions related to their gynecologic history and the use of estrogen modifying medications. Some of the variables included menstrual onset, the woman's age at the time of birth of her first child, use and duration of oral contraceptives and hormone replacement therapy, and age of the start of menopause.

In both groups, strong similarities existed across multiple screening factors. The median age of both groups was 53, and when comparing for pertinent criteria, the results were:

  • Body Mass Index was 27.1 for case group and 25.2 for control group.
  • Average age of menstrual onset was 13 years for both groups.
  • The average age for those whose first pregnancy occurred over 30 years of age was 10 percent for the case group and 11 percent for the control group.

When it concerned use of estrogen modifying agents such as oral contraceptives and hormone replacement therapy, there were major differences among the two groups. The rate of oral contraceptive usage in the case group was 60 percent compared to 77.6 percent for the control group.

Also, the rate of hormone replacement therapy usage was 23.7 percent for the case group and 44.8 percent for the control group. Also, when comparing the median duration of oral contraceptive use, results showed that the average duration was 2.6 years for the case group and 5.2 years for the control group.

"These differences in the usage of estrogen modifying agents qualify as statistically significant and indicate that women with brain aneurysms use oral contraceptives and hormone replacement therapy less frequently than the general population," said Chen. "It is reasonable to conclude that the data results support our hypothesis that drops in estrogen that occur in menstruation and particularly at menopause may explain why cerebral aneurysms are more frequently found in women, particularly at menopause."

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Contact: Deb Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

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