Oral contraceptives and hormone replacement therapy may protect women against brain... ( (CHICAGO) Results from a new study ...)

Oral contraceptives and hormone replacement therapy may protect women against brain aneurysms

Date:7/30/2010

(CHICAGO) Results from a new study suggest that oral contraceptives and hormone replacement therapy (HRT) may yield additional benefit of protecting against the formation and rupture of brain aneurysms in women. The findings from this first-of-its-kind study by a neurointerventional expert from Rush University Medical Center were presented at the Society of Neurointerventional Surgery (SNIS) 7th annual meeting.

According to the lead author of the study, Dr. Michael Chen, neurointerventionalist at Rush, the retrospective, case-control study was initiated due to the observation that in the two largest brain aneurysm trials to date, cerebral aneurysms occurred most frequently in post-menopausal women.

The two trials, the International Subarachnoid Aneurysm trial and the International Study of Unruptured Intercranial Aneurysms, found that 70 percent of aneurysms occurred in post-menopausal women with the mean age of 52 at a time of life coinciding with a severe drop in estrogen levels.

"By understanding the potential link between low levels of estrogen and aneurysms, we can focus our areas of study with the hope of providing women who are at risk for brain aneurysms with preventative therapies," said Chen, who also is assistant professor of neurology, neurosurgery and radiology at Rush University.

Conducted over a two-year period from 2008-2010, researchers at Rush also studied a group of 60 women with both unruptured and ruptured aneurysms. Sixty-five percent of the cases were unruptured and 35 percent were cases where women had ruptured aneurysms. The ages of the women who participated in the study ranged from 31-80, and were under the care of Dr. Chen and his team.

By comparing a variety of factors in this case group to that of a control group including 4,682 random females, who represented national population averages, Chen and his team aimed to determine if a link existed between lower estrogen levels and aneur
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Contact: Deb Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

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