Navigation Links
Oral bacteria may signal pancreatic cancer risk
Date:9/18/2012

PROVIDENCE, R.I. [Brown University] A new study finds significant associations between antibodies for multiple oral bacteria and the risk of pancreatic cancer, adding support for the emerging idea that the ostensibly distant medical conditions are related.

The study of blood samples from more than 800 European adults, published online Sept. 18 in the journal Gut, found that high antibody levels for one of the more infectious periodontal bacterium strains of Porphyromonas gingivalis were associated with a two-fold risk for pancreatic cancer. Meanwhile, study subjects with high levels of antibodies for some kinds of harmless "commensal" oral bacteria were associated with a 45-percent lower risk of pancreatic cancer.

"The relative increase in risk from smoking is not much bigger than two," said Brown University epidemiologist Dominique Michaud, the paper's corresponding author. "If this is a real effect size of two, then potential impact of this finding is really significant."

Pancreatic cancer, which is difficult to detect and kills most patients within six months of diagnosis, is responsible for 40,000 deaths a year in the United States.

Several researchers, including Michaud, have found previous links between periodontal disease and pancreatic cancer. The Gut paper is the first study to test whether antibodies for oral bacteria are indicators of pancreatic cancer risk and the first study to associate the immune response to commensal bacteria with pancreatic cancer risk. The physiological mechanism linking oral bacteria and pancreatic cancer remains unknown, but the study strengthens the suggestion that there is one.

"This is not an established risk factor," said Michaud, who is also co-lead author with Jacques Izard, of the Forsyth Institute and Harvard University. "But I feel more confident that there is something going on. It's something we need to understand better."

Izard, a microbiologist, said the importance of bacteria in cancer is growing. "The impact of immune defense against both commensals and pathogenic bacteria undeniably plays a role," he said. "We need to further investigate the importance of bacteria in pancreatic cancer beyond the associated risk."

Prospective, controlled study

To conduct their research, Michaud and Izard drew on medical records and preserved blood samples collected by the Imperial College-led European Prospective Investigation into Cancer and Nutrition Study, a massive dataset of more than 500,000 adults in 10 countries. Detailed health histories and blood samples are available from more than 380,000 of the participants.

From that population, the researchers found 405 people who developed pancreatic cancer, but no other cancer, and who had blood samples available. The researchers also selected 416 demographically similar people who did not develop pancreatic cancer for comparison.

The researchers blinded themselves to which samples came from cancer patients and which didn't during their analysis of the blood, which consisted of measuring antibody concentrations for 25 pathogenic and commensal oral bacteria. In their study design and analysis they controlled for smoking, diabetes, body mass index, and other risk factors.

An important element of the study design was that date of the blood samples preceded the diagnosis of pancreatic cancer by as much as a decade, meaning that the significant difference in antibody levels were likely not a result of cancer.

Instead, the underlying mechanisms that link Porphyromonas gingivalis to pancreatic cancer could be causal, Michaud said, although much more research is needed to understand this association.

Meanwhile, the researchers speculate, the association of high levels of antibodies for commensal bacteria and pancreatic cancer, may indicate an innate, highly active immune response that is protective against cancer.

"Genetic determinants of immune surveillance clearly play a critical role in pancreatic cancer development," the authors wrote. "Consequently, it is plausible that elevated levels of antibodies to oral bacteria in individuals serve as a marker for a genetically stronger immune response, providing protection against carcinogenesis."

Michaud, who studies cancer risk factors generally, continues to investigate the association between oral bacteria and pancreatic cancer in collaboration with Izard.


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Related medicine news :

1. Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
2. Superpowered Bacteria May Lurk Behind Sinus Infections
3. Feces-Linked Bacteria Found at Lake Erie Beaches
4. Could Bacteria in Skin Mites Help Cause Rosacea?
5. New antibacterial coating for sutures could reduce infections after surgery
6. Trudeau researchers identify unforeseen regulation of the anti-bacterial immune response
7. Microbiology and Genome Experts Quell Deadly Bacteria Outbreak
8. NIH uses genome sequencing to help quell bacterial outbreak in Clinical Center
9. Genes carried by E. coli bacteria linked to colon cancer
10. Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
11. Chronic exposure to staph bacteria may be risk factor for lupus, Mayo study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oral bacteria may signal pancreatic cancer risk
(Date:3/22/2017)... ... March 22, 2017 , ... University Orthopedics ... Orthopedic Surgery, Division of Hand, Upper Extremity and Microvascular Surgery at Newport Hospital. ... board-certified in both Orthopedics and Hand Surgery. , As the leader of ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... protection assistance and financial consultations to families and business owners in the greater ... for the local American Cancer Society Relay For Life event. , Each year, ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Zabbia Insurance Agency, ... families and business owners in the greater Nassau County area, is embarking on ... , Every 3 minutes, someone in America is diagnosed with blood cancer. Every ...
(Date:3/22/2017)... ... ... HumanHaus is proud to announce the launch of its newest invention on ... was invented, but our customers today are busy, energetic, multi-taskers that live in a ... nesters and retired that want to travel. The Sweep&Stand is a self-standing ...
(Date:3/22/2017)... San Diego, CA (PRWEB) , ... March 22, 2017 , ... ... Specialty Health Inc. as one of San Diego’s Best and Brightest in Wellness® ... innovative healthcare strategies and its model use of best practices in wellness for its ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017  Varex Imaging Corporation ... entered into a renewed three-year pricing agreement with Toshiba ... supply its computed tomography (CT) tubes for integration into ... This renewed agreement will be effective April 1, 2017. ... this renewed agreement are estimated to be in the ...
(Date:3/22/2017)... Ill. , March 22, 2017 ... innovative solutions for patients who suffer from advanced ... management team. Recent hires include experienced medtech executives ... (CMO), Richard Powers , Chief Information Officer ... of Manufacturing and Operations, who bring a wealth ...
(Date:3/22/2017)... SAN DIEGO , March 22, 2017 /PRNewswire/ ... company, announced today that it has entered into ... direct placement of 1,312,000 shares of common stock ... aggregate gross proceeds of $3,148,800.  The offering is ... 2017, subject to satisfaction of customary closing conditions. ...
Breaking Medicine Technology: