Navigation Links
Oral Drug Helps Prevent Clotting After Hip Replacement
Date:6/25/2008

Daily dose of rivaroxaban cut risk of venous thromboembolism, study finds

WEDNESDAY, June 25 (HealthDay News) -- Extended use of the oral drug rivaroxaban helps prevent potentially fatal blood clots after hip replacement surgery, British researchers say.

The risk of venous thromboembolism (VTE) is high after total hip replacement, and the risk can persist after a patient leaves hospital. Current guidelines recommend patients receive a heparin-based preventive drug such as enoxaparin (Lovenox) for a minimum of 10 days, and up to 35 days, after surgery. However, this preventive treatment is not used much after patients leave hospital, according to background information in the study.

The researchers at the London School of Medicine and Dentistry and the Thrombosis Research Institute compared the new oral antithrombotic drug rivaroxaban (Xarelto) with enoxaparin in the treatment of hip replacement patients.

In the randomized, controlled trial, 1,252 patients received 10 milligrams of oral rivaroxaban once daily for 31 to 39 days, followed by placebo injection for 10 to 14 days, while 1,257 patients received 40 milligram once-daily injections of enoxaparin for 10 to 14 days, followed by placebo tablets for 31 to 39 days.

The completed analysis of 864 patients in the rivaroxaban group and 869 patients in the enoxaparin group found that patients in the enoxaparin group were more than four times as likely to suffer deep vein thrombosis, nonfatal pulmonary embolism, or die than patients in the rivaroxaban group -- 9.3 percent versus 2 percent. Both groups had similar rates of bleeding events during treatment.

"Extended thromboprophylaxis with rivaroxaban was significantly more effective than short-term enoxaparin plus placebo for the prevention of venous thromboembolism, including symptomatic events, in patients undergoing total hip arthroplasty [replacement]," the researchers concluded.

The study was released online Wednesday by The Lancet and will be published in an upcoming issue.

"With superior efficacy, no compromise in safety, and a convenient once-daily regimen, rivaroxaban seems an obvious choice for simplified thromboprophylaxis after hip or knee arthroplasty [replacement]," Dr. John Eikelboom and Jeffrey Weitz, of McMaster University in Hamilton, Ontario, Canada, wrote in an accompanying editorial.

More information

The American Academy of Orthopaedic Surgeons has more about total hip replacement.



-- Robert Preidt



SOURCE: The Lancet, news release, June 25, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Heel Ultrasound Helps Detect Fracture Risk
2. Bat Scan to the Rescue: New Clubhouse CT Scanner Helps Eliminate Exploding Bats
3. Pro Baseball Helps Keep Skin Cancer From Scoring
4. Caregiverlist.com Helps Families Find Quality Senior Care
5. World Renowned Hand Surgeon Helps Patients Conquer Joint Discomfort Naturally
6. Nature Made SAM-e Complete Helps Americans Find Their Good Moods
7. Gene Therapy Helps Dogs Stricken With Cancer
8. New study shows American Cancer Society program helps employers
9. Estrogen therapy helps or hurts the brain depending on reproductive status
10. Online Scheduler Helps Track Kids Shots
11. MassMutual Announces Web Site Enhancement That Helps Employees Save for Retirement Sooner
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... , ... May 28, 2016 , ... In a part of the city where’s it’s ... new farm-to-table Kelowna restaurants is hoping to attract diners with a taste for ... Suites officially opened the doors to Cornerstone Grill, an urban casual restaurant focusing on ...
(Date:5/27/2016)... ... 27, 2016 , ... W.S. Badger Co. Inc ., the maker of ... recognized as one of the best small businesses for new dads by Fatherly, the ... small businesses providing progressive benefits to new parents on the organization’s 2016 Best ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational campaign aimed at ... stories, courtesy of awareness-driven celebrities and thought leaders. It also provides insight to ... industry leaders such as Bioness. , As patients feel increasingly concerned about ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... Aimed ... inspiring human interest stories, which come courtesy of leaders in the nursing and health ... industry, from leading advocates and associations—namely Abilene Christian University. , As the nursing ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... There are ... Hot Dog and Sausage Council (NHDSC) suggests that Americans prefer their dogs straight off ... 63 percent say grilling is their favorite way to cook a hot dog, far ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... - DCGI grants limited approval to market ... - Stempeucel® becomes 5th off-the-shelf Stem cell product to ... - Buerger,s Disease (also known as Thromboangiitis Obliterans) is a ... Globally - Prevalence of Buerger,s Disease is estimated to ... 10,000 persons in the European Community & USA ...
(Date:5/27/2016)... , May 27, 2016 According ... of hypertension is driving ambulatory blood pressure monitoring system ... elasticity and their ability to respond to different pressure ... condition can lead to various cardiovascular disorders such as ... disease. These diseases are growing in prevalence each year. ...
(Date:5/26/2016)... , May 26, 2016 According to ... Waste Management Market - U.S. Industry Analysis, Size, Share, Growth, ... market in the U.S. was valued at US$ 5.89 Bn ... of 3.4% from 2015 to 2023 to reach US$ 7.99 ... of current and emerging needle free drug delivery devices and ...
Breaking Medicine Technology: