Navigation Links
Oral Drug Helps Prevent Clotting After Hip Replacement
Date:6/25/2008

Daily dose of rivaroxaban cut risk of venous thromboembolism, study finds

WEDNESDAY, June 25 (HealthDay News) -- Extended use of the oral drug rivaroxaban helps prevent potentially fatal blood clots after hip replacement surgery, British researchers say.

The risk of venous thromboembolism (VTE) is high after total hip replacement, and the risk can persist after a patient leaves hospital. Current guidelines recommend patients receive a heparin-based preventive drug such as enoxaparin (Lovenox) for a minimum of 10 days, and up to 35 days, after surgery. However, this preventive treatment is not used much after patients leave hospital, according to background information in the study.

The researchers at the London School of Medicine and Dentistry and the Thrombosis Research Institute compared the new oral antithrombotic drug rivaroxaban (Xarelto) with enoxaparin in the treatment of hip replacement patients.

In the randomized, controlled trial, 1,252 patients received 10 milligrams of oral rivaroxaban once daily for 31 to 39 days, followed by placebo injection for 10 to 14 days, while 1,257 patients received 40 milligram once-daily injections of enoxaparin for 10 to 14 days, followed by placebo tablets for 31 to 39 days.

The completed analysis of 864 patients in the rivaroxaban group and 869 patients in the enoxaparin group found that patients in the enoxaparin group were more than four times as likely to suffer deep vein thrombosis, nonfatal pulmonary embolism, or die than patients in the rivaroxaban group -- 9.3 percent versus 2 percent. Both groups had similar rates of bleeding events during treatment.

"Extended thromboprophylaxis with rivaroxaban was significantly more effective than short-term enoxaparin plus placebo for the prevention of venous thromboembolism, including symptomatic events, in patients undergoing total hip arthroplasty [replacement]," the researchers concluded.

The study was released online Wednesday by The Lancet and will be published in an upcoming issue.

"With superior efficacy, no compromise in safety, and a convenient once-daily regimen, rivaroxaban seems an obvious choice for simplified thromboprophylaxis after hip or knee arthroplasty [replacement]," Dr. John Eikelboom and Jeffrey Weitz, of McMaster University in Hamilton, Ontario, Canada, wrote in an accompanying editorial.

More information

The American Academy of Orthopaedic Surgeons has more about total hip replacement.



-- Robert Preidt



SOURCE: The Lancet, news release, June 25, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Heel Ultrasound Helps Detect Fracture Risk
2. Bat Scan to the Rescue: New Clubhouse CT Scanner Helps Eliminate Exploding Bats
3. Pro Baseball Helps Keep Skin Cancer From Scoring
4. Caregiverlist.com Helps Families Find Quality Senior Care
5. World Renowned Hand Surgeon Helps Patients Conquer Joint Discomfort Naturally
6. Nature Made SAM-e Complete Helps Americans Find Their Good Moods
7. Gene Therapy Helps Dogs Stricken With Cancer
8. New study shows American Cancer Society program helps employers
9. Estrogen therapy helps or hurts the brain depending on reproductive status
10. Online Scheduler Helps Track Kids Shots
11. MassMutual Announces Web Site Enhancement That Helps Employees Save for Retirement Sooner
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... ... gynecological care and gynecological services for women of all ages. The ... a wide variety of reproductive services from routine health screenings to diagnosing and ...
(Date:1/23/2017)... ... ... “Crossing the Bar”: a moving and eloquent drama depicting the events ... is the creation of published author, Charlotte Hotte, a North Carolina native, a mother ... of the book to her sister, Denise, wishes to acknowledge her savior, Jesus Christ, ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Life Under Blankets”: an entrancing story about ... “Life Under Blankets” is the creation of published author, Kimberly Mitchell, who earned her ... She went on to pursue a master’s degree in education in the field of ...
(Date:1/23/2017)... ... ... Valentine’s Day is a time when many people celebrate romance and love by giving cards, ... for the ideal present, Atlanta-based Perimeter Plastic Surgery is offering a Valentine’s Day ... $200 and get $50 free. , “A lot of people just buy the more ...
(Date:1/22/2017)... (PRWEB) , ... January 22, 2017 , ... Zifam Pinnacle, ... across the world, recently met with big-name retail buyers at the January ECRM Trade ... of efficacy and uses the utmost safety standards in all of its creations to ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Stock-Callers.com today presents the following Generic ... CPRX ), Sophiris Bio Inc. (NASDAQ: SPHS ), ... Therapeutics Inc. (NASDAQ: AGRX ). These companies are ... late trade on Friday, January 20 th , 2017, with ... of health care companies in the S&P 500 also were ...
(Date:1/23/2017)... Januar 2017  ResMed (NYSE: RMD ), ... Medical ( Winter Haven, Florida ) gaben ... die Beilegung aller globalen Rechtsstreitigkeiten zwischen den Parteien geeinigt ... ihrer bestehenden Produkte im Tausch gegen Lizenzgebühren an ResMed ... leisten, um das in Florida ...
(Date:1/22/2017)... DAVOS, Switzerland and ABU DHABI , ... leaders from the US ... , Hospital of the Future , at ... in the hospital of the future will be driven by big data and ... better," according to the panel of experts that discussed the ,Hospital of the ...
Breaking Medicine Technology: