Navigation Links
Oral Drug Ups Survival in Advanced Prostate Cancer Cases
Date:8/11/2009

But no reduced death risk in patients with localized disease, research shows

TUESDAY, Aug. 11 (HealthDay News) -- Oral sodium clodronate improves overall survival in advanced prostate cancer patients but doesn't reduce the risk of death in those with localized disease, British researchers say.

They reported on the long-term survival outcomes of more than 800 men enrolled in two trials launched in 1994. The trials examined the effects of sodium clodronate in patients with advanced (311 men) or localized prostate cancer (508 men).

The advanced prostate cancer patients who received the drug had a 23 percent lower death rate than patients who took a placebo. After five years, overall survival was 30 percent among men who took oral sodium clodronate and 21 percent among those in the placebo group. After 10 years, the survival rates were 17 percent and 9 percent, respectively, the researchers found.

However, the drug offered no improvement in overall survival to men with localized prostate cancer. After five years, overall survival was 78 percent among those who took clodronate and 80 percent among those given a placebo. After 10 years, the survival rates were 48 percent and 51 percent, respectively.

The findings are believed to be the first "to show an overall survival benefit conferred by an oral bisphosphonate when given in addition to standard hormone therapy to men with bone metastases who are starting or responding to hormone therapy," wrote Matthew Sydes, of the Medical Research Council Clinical Trials Unit, and colleagues. "However, there is no evidence that clodronate is of any benefit when given as an adjuvant to treatment in men with non-metastatic prostate cancer."

The study appears online and in the September print issue of The Lancet Oncology.

More information

The U.S. National Cancer Institute has more about prostate cancer treatment.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Aug. 10, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
4. Human C-reactive protein regulates myeloma tumor cell growth and survival
5. Mediterranean Diet May Boost Alzheimers Survival
6. Hospitals Improve Survival Rates While Treating Sicker Patients Thomson Healthcare Study Shows
7. The Fight for His Life: Author, Family Battle Disease and Challenge Politics in the Face of Survival
8. Communication in cancer world is key to survival
9. Molecular profiling can accurately predict survival in colon cancer patients
10. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
11. Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oral  Drug Ups Survival in Advanced Prostate Cancer Cases
(Date:7/24/2017)... ... 2017 , ... Peruvian Ayahuasca retreat, East West Lodge, announced ... and divided between two full-time university students enrolled in U.S. or Canadian accredited ... apply for the scholarship, students are asked to submit an essay between 750 ...
(Date:7/24/2017)... ... ... The International Essential Tremor Foundation (IETF) will host a free educational forum in ... take place on Saturday, Aug. 26 at the Embassy Suites by Hilton Cleveland Rockside ... a.m. to 12 p.m., with check-in beginning at 8 a.m. The event is sponsored ...
(Date:7/24/2017)... ... , ... Every year, thousands of dedicated Higher Education and K12 professionals flock ... coupled with a dynamic theme like Camp Canvas; this year, they’ve managed to take ... , To extend their partnership with Canvas beyond the LMS integration, Modo Labs secured ...
(Date:7/24/2017)... CA (PRWEB) , ... July 24, 2017 , ... ... financial organizations, today announced it has partnered with WALLIX to expand its ... Publication 800-171 . , There are a number of ways to address the authentication ...
(Date:7/24/2017)... ... July 24, 2017 , ... The Topricin Companies, formerly Topical ... Topricin’s revolutionary, natural, after-burn skin care product, Topricin After Burn Cream. ... term skin conditions, including cancer. In the short term, overexposure to sun, ...
Breaking Medicine News(10 mins):
(Date:7/24/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) announced ... operating results on Monday, August 7, 2017 after market ... p.m. ET. Shareholders ... of the conference call by dialing 877-201-0168 or 647-788-4901 ... 15 minutes prior to the call. A live webcast ...
(Date:7/21/2017)... EDMONTON, Alberta , July 21, 2017  IBM ... of Alberta in Edmonton, Canada ... journal, Schizophrenia 1 , demonstrating that AI and ... with 74% accuracy. This retrospective analysis also showed ... in schizophrenia patients with significant correlation, based on ...
(Date:7/21/2017)... SPRING, Md. and RESEARCH TRIANGLE ... United Therapeutics Corporation (NASDAQ: UTHR ) announced ... financial results before the market opens on Thursday, July ... Therapeutics will host a teleconference on Thursday, July 27, ... accessible by dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  ...
Breaking Medicine Technology: