Navigation Links
Optogenetics illuminates pathways of motivation through brain, Stanford study shows
Date:11/18/2012

want to move.

"This is one of the most debilitating aspects of depression, and motivation to take action is something that we can model in animals. That's the exciting opportunity for us as researchers," said Deisseroth, who also holds the D.H. Chen Professorship.

Light coercion

Psychiatrists, Deisseroth included, believe the will to act may be born in the prefrontal cortex the foremost part of the brain that helps plan and coordinate action. It then zips through the brain as a series of electrical signals, passing from neuron to neuron along countless branching pathways until it reaches the nerves that directly implement movement. Until this study, however, it was not clear which of these pathways might control the willingness to meet challenges, or the anticipation that action might be worthwhile in a difficult situation.

To isolate these pathways relevant to depression, Deisseroth's team needed to stimulate specific brain cells in rodents and observe changes in their behavior. They used optogenetics, a technique Deisseroth developed at Stanford in 2005, which has since revolutionized the fields of bioengineering and neuroscience.

The secret is as old as green algae. These single-celled organisms produce a protein called channelrhodopsin that makes them sensitive to sunlight. Borrowing and engineering the gene for this protein, Deisseroth has been able to create neurons that respond to light delivered from fiber-optic cables. He can turn the neurons on and off by sending bursts of light to activate different areas of the brain and then observe the effects on behavior.

Working backward

Surprisingly, the researchers found that simply stimulating the prefrontal cortices of rodents didn't motivate them to try any harder in a laboratory challenge. It turns out that motivation is not as simple as stimulating a region of the brain. Instead of one switch in the prefrontal cortex that turns motiv
'/>"/>

Contact: Andrew Myers
admyers@stanford.edu
650-736-2245
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Optogenetics project takes top NIDA Addiction Science Award
2. How tumor cells create their own pathways
3. Following the genomic pathways to stop the spread of cancer
4. Discovery explains how cellular pathways converge to regulate food intake and body weight
5. Global Energy Assessment identifies pathways to a sustainable energy future
6. VCU researchers identify changes in cholesterol metabolic pathways
7. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
8. Virtual boundaries: How environmental cues affect motivation and task-oriented behavior
9. BYU study: Exercise may affect food motivation
10. Research breakthrough could halt melanoma metastasis
11. Advancing understanding of treatment through clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... TUESDAY, Dec. 16, 2014 (HealthDay News) -- Greater participation ... new study finds. Researchers followed kids in the ... to poor children in Los Angeles. Over two ... larger improvements in how the brain processes speech and ... Also, the benefits of active participation in music ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, 2014 (HealthDay ... work commitment is a big reason why, new research suggests. ... Mathias Basner, an assistant professor of sleep and chronobiology in ... A time-use survey of nearly 125,000 Americans, ages 15 ... exchanged for sleep. Short sleepers -- those who slept six ...
(Date:12/15/2014)... December 15, 2014 Veretekk.com, Inc. announced ... Ocean Avenue. JM Ocean Avenue has secured exclusive ... online automated marketing system. JM Ocean Avenue is ... merger of Ocean Avenue and JM International, with partial ... Billion per year company. , “After nearly 2 decades ...
(Date:12/15/2014)... SIMpalm, a leading mobile app development company , ... client, which allows users to keep track of wines ... the right wine. At the center of WineMatch ... and wine information. All this information is assembled to ... that are close counterparts to one another are called ...
(Date:12/15/2014)... Steven Reinberg HealthDay Reporter ... study should reassure the millions of American women who have ... cancer. "There is no association between migraine and breast ... of medicine at Harvard Medical School. "There is no positive ... is no protective effect either." About 18 percent of ...
Breaking Medicine News(10 mins):Health News:Music Classes Boost Language Skills, Study Says 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 2Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 4Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2
... Web Site Strategy and Design, NEW YORK, ... been selected to develop a new web site ... of Public Health, one of the world,s,leading research, ... public health issues., "The Mailman website provides ...
... the,release of a new slimmer and more streamlined SenseWear(R) ... is 40% smaller than the previous model and weighs ... ergonomic,design intended to provide improved comfort and can be ... little device that could have a huge impact on,behavior ...
... Detroit bring up the rear, survey says , , MONDAY, May ... hearts in tip-top shape face the fewest challenges in Minneapolis, ... the list of the 10 most heart-healthy U.S. metropolitan areas ... But the list, released Monday by the American Heart Association, ...
... unnecessary surgeries , , MONDAY, May 19 (HealthDay News) ... lectin molecule called galectin-3 could help improve identification of ... surgeries, according to an Italian study. , The ... is to examine cells extracted by fine-needle aspiration. About ...
... survey says , , MONDAY, May 19 (HealthDay News) -- Women ... the fewest challenges in Minneapolis, Washington, D.C., and San Francisco. ... most heart-healthy U.S. metropolitan areas for women, a list that,s ... by the American Heart Association, also found the 10 metropolitan ...
... Disease Awareness Levels, However, ... More Doctor Visits Are Still Needed -, ... three,years, Hispanic-Americans have become increasingly aware of a potentially,serious ... Reflux Disease. Approximately 6.1 million Hispanics in the United,States ...
Cached Medicine News:Health News:Format-Studio Selected by Columbia University Mailman School of Public Health 2Health News:BodyMedia Releases New & Improved SenseWear(R) WMS Armband 2Health News:Minneapolis Tops List of Heart-Friendly Cities for Women 2Health News:Minneapolis Tops List of Heart-Friendly Cities for Women 3Health News:Protein Helps ID Thyroid Cancer Nodules 2Health News:Minneapolis Tops List of Heart-Healthy Cities for Women 2Health News:Minneapolis Tops List of Heart-Healthy Cities for Women 3Health News:New Survey Reveals Hispanic-Americans Are Taking Steps to Better Understand and Manage GERD 2Health News:New Survey Reveals Hispanic-Americans Are Taking Steps to Better Understand and Manage GERD 3Health News:New Survey Reveals Hispanic-Americans Are Taking Steps to Better Understand and Manage GERD 4Health News:New Survey Reveals Hispanic-Americans Are Taking Steps to Better Understand and Manage GERD 5
(Date:12/14/2014)... , Dec. 14, 2014  ChartSpan, a consumer ... most downloaded iPhone and iPad medical app in ... - http://photos.prnewswire.com/prnh/20141214/164317 ChartSpan is ... ability to request, manage and send electronic healthcare records. ... entrepreneurs who grew tired of waiting for the healthcare ...
(Date:12/13/2014)... DUBLIN , December 12, 2014 /PRNewswire/ ... ) has announced the addition of the  ... - Size, Share, Global Trends, Company Profiles, ...  report to their offering.  ... thin tubes made up of medical grade ...
(Date:12/13/2014)... Dec. 12, 2014 HudsonAlpha Institute for ... X Ten sequencing system manufactured by Illumina, Inc. ... produce and analyze genomic data faster and at ... Institute,s commitment to research programs for genomics excellence ... Ten provides unprecedented capacity, speed and accuracy for ...
Breaking Medicine Technology:ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3Global Catheters Market (Product Types and Geography) - Forecast to 2020 2Global Catheters Market (Product Types and Geography) - Forecast to 2020 3HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 3
... Oct. 20, 2011 A 76-year-old man suffering from ... is now pain-free, thanks to the world,s first implantation ... (Logo: http://photos.prnewswire.com/prnh/20111020/DC90730LOGO )   ... the patient was treated at Carolinas Rehabilitation in Charlotte, ...
... Virginia Dental Association honored Henry Schein Cares, the ... Inc. (NASDAQ: HSIC ), the largest ... office-based practitioners, with the organization,s first Corporate Partner ... Annual Meeting held in Las Vegas, Nev.  The ...
Cached Medicine Technology:World's First Implantation of SPR™ System for Chronic Pain 2World's First Implantation of SPR™ System for Chronic Pain 3The Virginia Dental Association Honors Henry Schein Cares With the Organization's First Corporate Partner Award 2The Virginia Dental Association Honors Henry Schein Cares With the Organization's First Corporate Partner Award 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: