Navigation Links
Optogenetics illuminates pathways of motivation through brain, Stanford study shows
Date:11/18/2012

want to move.

"This is one of the most debilitating aspects of depression, and motivation to take action is something that we can model in animals. That's the exciting opportunity for us as researchers," said Deisseroth, who also holds the D.H. Chen Professorship.

Light coercion

Psychiatrists, Deisseroth included, believe the will to act may be born in the prefrontal cortex the foremost part of the brain that helps plan and coordinate action. It then zips through the brain as a series of electrical signals, passing from neuron to neuron along countless branching pathways until it reaches the nerves that directly implement movement. Until this study, however, it was not clear which of these pathways might control the willingness to meet challenges, or the anticipation that action might be worthwhile in a difficult situation.

To isolate these pathways relevant to depression, Deisseroth's team needed to stimulate specific brain cells in rodents and observe changes in their behavior. They used optogenetics, a technique Deisseroth developed at Stanford in 2005, which has since revolutionized the fields of bioengineering and neuroscience.

The secret is as old as green algae. These single-celled organisms produce a protein called channelrhodopsin that makes them sensitive to sunlight. Borrowing and engineering the gene for this protein, Deisseroth has been able to create neurons that respond to light delivered from fiber-optic cables. He can turn the neurons on and off by sending bursts of light to activate different areas of the brain and then observe the effects on behavior.

Working backward

Surprisingly, the researchers found that simply stimulating the prefrontal cortices of rodents didn't motivate them to try any harder in a laboratory challenge. It turns out that motivation is not as simple as stimulating a region of the brain. Instead of one switch in the prefrontal cortex that turns motiv
'/>"/>

Contact: Andrew Myers
admyers@stanford.edu
650-736-2245
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Optogenetics project takes top NIDA Addiction Science Award
2. How tumor cells create their own pathways
3. Following the genomic pathways to stop the spread of cancer
4. Discovery explains how cellular pathways converge to regulate food intake and body weight
5. Global Energy Assessment identifies pathways to a sustainable energy future
6. VCU researchers identify changes in cholesterol metabolic pathways
7. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
8. Virtual boundaries: How environmental cues affect motivation and task-oriented behavior
9. BYU study: Exercise may affect food motivation
10. Research breakthrough could halt melanoma metastasis
11. Advancing understanding of treatment through clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ ... Alliance (PPHA). The PPHA's passion for others' well-being and ... greats, treated for obstructive sleep apnea (OSA) has propelled them ... in the valley. The most recent plans for an event ...
(Date:1/22/2015)... 2015 The Incredible Bulk is a revolutionary ... increase lean muscle by up to 30lbs in less than ... of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... step-by-step, scientific diet formula that allows the body to pack ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue ... means to “Live Fearless.” , The “Faces of ... stories about how they or someone they know has faced ... in the moment. By telling these types of stories through ...
(Date:1/22/2015)... The federal court overseeing thousands of vaginal mesh ... District of West Virginia has upheld a $2 million verdict ... trial. In an Order dated January 21st, the Court denied ... C.R. Bard had not proven a miscarriage of justice. (Cisson ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 A ... issue of experience and person-centeredness in the long-term care ... towards action across the continuum. The paper, “The Power ... Continuum,” engages perspectives and practices of the patient, resident ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3
... Inlog, S.A., Subsidiary Continues its Strong Sales Presence ... Med Technologies(R), Inc. ("Global Med" or the "Company") ... information technology company, today announced that its Inlog ... Information Management Software (Marketed as "Labo Serveur" in ...
... a leading provider of clinical documentation software, workflow ... consulting and training agreement with IASIS Healthcare. ... training regarding quality clinical documentation for IASIS physicians.Precyse ... to utilize physician trainers to conduct high-level education ...
... are warned of side effect that could hamper immigration ... widely used cancer drug capecitabine can cause people to ... they,re trying to enter the United States, an oncologist ... medical oncology at the National Cancer Centre in Singapore, ...
... 27, 2009 -- Our brain is wired to identify ... a new study published in the Journal of ... de Montral team found the luminescence of the eyebrow ... , "As teenagers, dimorphism (systematic difference between sexes) ...
... on prevention and information can lead to healthier livesST. ... partnership with Healthwise(R) to rollout a new consumer health ... currently provides to its customers. Nurse Response will offer ... will allow eligible Nurse Response consumers to access over ...
... $18 million, three-year grant to develop new and more ... to a multi-institutional "Dream Team" of scientists and clinicians ... researcher with the U.S. Department of Energy,s Lawrence Berkeley ... Up To Cancer, an Entertainment Industry Foundation charitable organization ...
Cached Medicine News:Health News:Global Med Technologies(R), Inc. Licenses and Deploys its EdgeLab Laboratory Software at Eugene Andre Hospital in Lyon, France 2Health News:Global Med Technologies(R), Inc. Licenses and Deploys its EdgeLab Laboratory Software at Eugene Andre Hospital in Lyon, France 3Health News:Global Med Technologies(R), Inc. Licenses and Deploys its EdgeLab Laboratory Software at Eugene Andre Hospital in Lyon, France 4Health News:IASIS Healthcare and Precyse Solutions Sign Two-Year Consulting Agreement 2Health News:IASIS Healthcare and Precyse Solutions Sign Two-Year Consulting Agreement 3Health News:Fingerprints May Vanish With Cancer Drug 2Health News:Berkeley Lab scientist co-leads breast cancer 'dream team' 2Health News:Berkeley Lab scientist co-leads breast cancer 'dream team' 3
(Date:1/23/2015)... 23, 2015   Leatt Corporation  (OTCQB: LEAT), a global ... all forms of sports, including extreme motor sports, and ... today that the UISP Lega Motociclismo Lombardia, an Italian ... to wear a neck brace during its racing competitions.  ...
(Date:1/23/2015)... Jan. 23, 2015  Mallinckrodt plc (NYSE: MNK ... approved a share repurchase program. The open-ended authorization permits ... Mallinckrodt plc ordinary shares. "Funding additional ... priorities as we continue to pursue a range of ...
(Date:1/23/2015)... LONDON and BOSTON , January ... structure-guided drug discovery and development company, is delighted to announce ... has been awarded to Miles Congreve (Vice President ... co-founder) and Malcolm Weir (Chief Executive Officer and ...
Breaking Medicine Technology:Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4
... Medical Imaging of Fredericksburg is one of ...  Best of 2011 Radiology Facilities issue, a ... In an article titled "Small Town ... Imaging of Fredericksburg, a partnership between Mary Washington ...
... Inc., a biotechnology company developing orally-available antiviral therapeutics, ... for CMX001 in a late-breaker presentation at the ... Chemotherapy (ICAAC, Chicago – September 17-20).   ... Diseases Service at Memorial Sloan-Kettering Cancer Center and ...
Cached Medicine Technology:Medical Imaging of Fredericksburg Highlighted in Imaging Economics' Best of 2011 Radiology Facilities Issue 2Chimerix Announces Late-Breaker Presentation at 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Annual Meeting 2Chimerix Announces Late-Breaker Presentation at 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Annual Meeting 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: