Navigation Links
Options increase for CML patients failed by existing drugs
Date:12/21/2012

HOUSTON The U.S. Food and Drug Administration (FDA) this month expanded the options for patients with chronic myeloid leukemia and one form of acute lymphoblastic leukemia that carries the Philadelphia chromosome (Ph+ALL). It approved the drug ponatinib (Iclusig), which is effective in a significant number of patients with either disease.

Patients with both leukemias have enjoyed strong responses to imatinib (Gleevec) and second-generation drugs nilotinib (Tasigna) and dasatinib (Sprycel). All work by inhibiting proteins called tyrosine kinases on leukemia cells, in particular the aberrant BCR-ABL protein that causes these diseases.

However, 30-40 percent of CML patients resist imatinib. Nilotinib and dasatinib work for about 40-50 percent of those patients.

"Ponatinib's availability will drastically improve the outcome of most patients with CML and PH+ALL who are resistant or intolerant to prior tyrosine kinase inhibitor therapy," said Jorge Cortes, M.D., professor and deputy chair, in The University of Texas MD Anderson Cancer Center Department of Leukemia.

"Clinical responses to Iclusig have been observed in patients regardless of their mutation status or disease stage. It's a valuable new treatment option for leukemia patients," Cortes said.

New drugs fill gaps in treatment

Ponatinib is the third drug approved by the FDA for CML and Ph+ALL during the past four months, providing oncologists with a wealth of options. Cortes led all of the clinical trials for the three drugs. The other two are bosutinib (Bosulif) and omacetaxine (Synribo). Cortes and other Leukemia Department faculty also led many of the clinical trials for the three previously approved CML therapies.

"It's important to have as many therapies against cancer as we can, because rarely does one drug or combination succeed for all patients," Cortes said. "These new drugs cover different gaps in treatment, so they can serve our patients in different way
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Version 2.0 of Award-Winning Proloquo2Go App for iPhone, iPad & iPod touch Speeds Up Communication, Adds New Voices and Customization Options
2. Mesothelioma Victims Center Now Urges US Navy Veterans Or Individuals With Mesothelioma To Call Them For The Names Of The Best Mesothelioma Attorneys & Treatment Options
3. Menu labeling requirements lead to healthier options at chain restaurants
4. Options Increasing for Coping With Kids Food Allergies
5. Existing drugs offer new treatment options for high-risk childhood leukemia subtype
6. Many options, good outcomes, for early-stage follicular lymphoma
7. Little evidence supports autism treatment options in adolescents
8. New options for ease and accuracy in extraction of rare cells or separating blood
9. Policy considerations pose options for leaders to reduce costly disparities in diabetes
10. Fast food menu options double; calorie counts remain high
11. Tamoxifen trial should prompt breast cancer patients to reconsider treatment options
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Randy Dotinga HealthDay Reporter ... who have the largest number of post-traumatic stress disorder symptoms ... to food, a new study suggests. The findings ... or becoming addicted to food. And it,s also possible that ... PTSD, or both. Still, the research seems to ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Fit Body ... the fastest-selling fitness business in the country and its popularity, ... has continued to grow enormously in 2014. , The ... Conference, is taking place in Costa Mesa, CA on September ... the biggest conferences yet. Founder Bedros Keuilian, who is also ...
(Date:9/18/2014)... It is true that a ... building a successful brand or business online. Best ... recently compared plenty of professional web hosting suppliers ... and iPage are the best VPS hosting suppliers ... web hosting. All-sized businesses or enterprises can find ...
(Date:9/18/2014)... 18, 2014 In Pretrial Order ... Compel Discovery; Motion for Protective Order ), the ... the subject of multiple telephone conferences.” The first ... “new process for the collection, retention, storage, and ... mesh revision or removal procedures,” which process was ...
(Date:9/18/2014)... September 18, 2014 SMI ... MEMS low pressure sensor Series designed especially ... accuracy. The unique gage and differential offering allows ... 14-Bit resolution and 1% accuracy provide the user ... per year provides the reliability and long-term reliability ...
Breaking Medicine News(10 mins):Health News:PTSD Link to Food Addiction Seen in Report 2Health News:PTSD Link to Food Addiction Seen in Report 3Health News:With Fit Body Boot Camp World Conference Nearing, Founder Explains the Fitness Boot Camp Franchise’s Success 2Health News:With Fit Body Boot Camp World Conference Nearing, Founder Explains the Fitness Boot Camp Franchise’s Success 3Health News:Best Cheap Hosting USA: GreenGeeks, Arvixe And iPage Are The Best Hosting Suppliers In 2014 2Health News:Transvaginal Mesh Lawsuit News: Court Orders C.R. Bard to Turn Over Relevant Documents to Plaintiffs, the Rottenstein Law Group LLP Reports 2Health News:SMI Launches Digital MEMS Low Pressure Sensor 2
... , MONDAY, June 21 (HealthDay News) -- Using ear tubes ... cochlear implants, a new study finds. , U.S. researchers studied ... received ear tubes before cochlear implants. In 46 (59 percent) ... implantation surgery. In all the other cases, the ear tubes ...
... likely to develop allergies, asthma, study suggests , ... born vaginally pick up different bacteria than those who ... immune systems develop, a new study suggests. , ... born through cesarean sections appear to be more at ...
... DC) A recent study of an ancient language ... with potential applications for today,s world. The study, "Dvandvas, ... to Word," to be published in the June 2010 ... authored by Paul Kiparsky of Stanford University. A preprint ...
... the industrial chemical bisphenol A, or BPA, in the womb ... according to a new study conducted in animals. The results ... Meeting in San Diego. "We are seeing changes in ... that are lower than what the Food and Drug Administration ...
... 21, 2010 The recent revelation that the chair ... (IDRC) was a tobacco executive until April 2010 sends ... is no longer a priority, states an editorial ... ). "There is simply no place for the ...
... ... there is promoter activity behind the website. , ... (PRWEB) June 21, 2010 -- The Active Search Results Search Engine ( ... Ranking Technology (ASR Ranking). , , ,ASR Ranking allows search engines to rank search ...
Cached Medicine News:Health News:Ear Tubes Appear to Be Safe Before Cochlear Implantation 2Health News:Delivery Method May Determine the Bacteria Babies Acquire 2Health News:Delivery Method May Determine the Bacteria Babies Acquire 3Health News:The 'bumpy ride' of linguistic change 2Health News:Early-life exposure to BPA may affect testis function in adulthood 2Health News:CMAJ calls for resignation of IDRC chair Barbara McDougall 2Health News:Active Search Results Announces its New Search Engine Ranking Algorithm 2Health News:Active Search Results Announces its New Search Engine Ranking Algorithm 3
(Date:9/17/2014)... , Sept. 17, 2014 BRIC ... Summary GlobalData,s new report, "BRIC ... market data on the BRIC Gynecological Devices market. ... dollars, volume (in units) and average prices (in ... Devices (Transcervical Sterilization Devices (Micro-inserts) and Mechanical Sterilization ...
(Date:9/17/2014)... , Sept. 17, 2014 The ... the last decade due to the recession, ... and technological advancements. This BCC Research report ... segments of the ambulance and emergency medical ... blood and hemorrhage control devices, equipment used ...
(Date:9/17/2014)... 17, 2014 Pomerantz LLP is investigating claims ... BioPharma" or the "Company") (NASDAQ: PDLI).  Such investors are ... rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ... its officers and/or directors have violated Sections 10(b) and ... On September 17, 2014, the Company announced ...
Breaking Medicine Technology:BRIC Gynecological Devices Market Outlook to 2020 2BRIC Gynecological Devices Market Outlook to 2020 3Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of PDL BioPharma, Inc. - PDLI 2
... Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... subsidiaries, Valeant Pharmaceuticals North America LLC (VPNA) and ... agreement to acquire the assets of the Ortho ... pay Janssen $345 million for the assets, which ...
... Inc. (Nasdaq: CPIX ) announced today that ... market closes on Thursday, August 4, 2011.  A conference call ... 4, 2011, at 5:00 p.m. Eastern Time to discuss the ... 877-303-1298 (for U.S. callers) or 253-237-1032 (for international callers).  A ...
Cached Medicine Technology:Valeant Pharmaceuticals Agrees to Acquire Ortho Dermatologics 2Valeant Pharmaceuticals Agrees to Acquire Ortho Dermatologics 3
... centrifuges -- the world's most popular Microhematocrit ... one reliable, quiet, compact unit. It is ... separate centrifuges!, For your microcentrifuge needs, order ... you with the MicroMB centrifuge, microcentrifuge rotor ...
... spins up to 25,000 x g for quick and ... ease of use. The Model 5417 C is designed ... cold room and can accommodate a variety of microcentrifuge ... Spin up to 16,400 rpm; 25,000 x g ...
... The Model EXD explosion-proof laboratory floor model ... explosion-proof apparatus. EXD is suitable for use ... all divisions; "atmospheres containing gasoline, petroleum, naphtha, ... Adherence to these specifications is so strict ...
... Oven/Shaker rigidly controls the temperature and ... hybridization and washing steps. This facilitates ... nucleic acids and proteins immobilized on ... radioactive and nonradioactive labeling systems supplied ...
Medicine Products: