Navigation Links
Optical 'frequency comb' can detect the breath of disease
Date:2/19/2008

Exhale on a cold winter day and you will see the water vapor coming out of your mouth. Light up your breath with a Nobel-Prize-related tool, and you could potentially detect trace amounts of over 1,000 compounds, some of which provide early warning signs of disease. In a new paper,* a team led by Jun Ye, a physicist at JILA, a joint institute of the National Institute of Standards and Technology (NIST) and the University of Colorado at Boulder, has demonstrated an optical technique for simultaneously identifying tiny amounts of a broad range of molecules in the breath, potentially enabling a fast, low-cost screening tool for disease.

It is exciting to imagine the potential of analyzing all major biomarkers in ones breath at once, says Ye. For example, nitric oxide can indicate asthma, but it also appears in breath with many other lung diseases, including chronic obstructive pulmonary disease, cystic fibrosis and bronchiectasis. However, if we simultaneously monitor nitric oxide, carbon monoxide, hydro-peroxide, nitrites, nitrates, pentane, and ethane, all important biomarkers for asthma, we can be much more certain for a definitive diagnosis of this important disease.

Existing methods for detecting trace amounts of molecules from the breath are either bulky, slow, limited to specific molecules, unable to distinguish very well between multiple compounds or inaccurate at measuring their concentrations. In this new approach, the researchers analyze human breath with frequency combs, an optical tool cited in the 2005 Nobel Prize in Physics shared by JILA fellow Jan Hall. Frequency combs are generated by a laser specially designed to produce a series of very short, equally spaced pulses of light. Each pulse may be only a few millionth billionths of a second long. The laser generates light as a series of very narrow frequency peaks equally spaced, like the teeth of a comb, across a broad spectrum.

In the experiment, student volunteers exhaled breath that entered an optical cavity where it was combed by the light pulses. By detecting which colors of light were absorbed and in what amountsessentially looking for light absorbed near the teeth of the comb the researchers could detect specific molecules and their concentrations. For example, a student smoker who participated in the experiment had a level of carbon monoxide that was five times greater than a nonsmoker in the experiment. The optical comb approach allows the researchers to simultaneously analyze a very broad spectrum, covering many possible molecular compounds, with high precision, frequency resolution and sensitivity. The technique is in early phases, and would require clinical trials before it could become available at a doctors office, but it could lead to one of the first widespread applications of frequency combs.


'/>"/>

Contact: Ben Stein
bstein@nist.gov
301-975-3097
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related medicine news :

1. Transitions Optical Promotes Healthy Sight Through a Nationwide Integrated Advertising Campaign and the Launch of an Enhanced Consumer Web Site
2. Optical Coherence Tomography Market to Top $800 Million by 2012
3. Shamir Optical Industry Ltd. to Host Conference Call Announcing Third Quarter 2007 Earnings Results
4. Kensey Nash Announces Exclusive License of Optical Guidance Patent to Enhance Chronic Total Occlusion Platform
5. Minority patients prefer optical colonoscopy for colorectal cancer screening
6. Optical scientist honored for understanding and improving vision
7. Where vets served affects frequency of ER visits but not hospital stays
8. US hospitals report infections increasing in frequency and cost
9. Combination of Thyroid Medicines Not Necessary
10. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
11. The Ultimate Valentines Day Gift: Indulgent Organic Chocolate for Women That Combines Great Taste & Functional Ingredients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Optical 'frequency comb' can detect the breath of disease
(Date:2/23/2017)... ... 23, 2017 , ... Rare Disease Report®, which is the ... Rare Disease Day events, hosted by the Rare Disease Legislative Advocates (RDLA) on ... weekly e-newsletter and quarterly publication, will be conducting interviews with patients and advocates ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rosica Communications, a ... content marketing, social media management, corporate communications, SEO and cause marketing, is opening ... in nearby New Hampshire, Massachusetts and Canada, Rosica will focus on expanding its ...
(Date:2/23/2017)... ... February 23, 2017 , ... Pink Pig Publishing ... generations converge and explore the world from different perspectives. By providing a place ... to gain understanding, increase empathy, and find greater happiness. , "Our approach ...
(Date:2/23/2017)... RI (PRWEB) , ... February 23, 2017 , ... ... today a new partnership with the Rhode Island Consortium for Autism Research and ... an opportunity for children with autism spectrum disorder (ASD) to see films in ...
(Date:2/23/2017)... York (PRWEB) , ... February 23, 2017 , ... Curemark, ... the safety and efficacy of CM-AT in children aged 3-8 with Autism, is now ... clinical sites already enrolling children across the United States. , “There are currently ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb 23, 2017 Research and Markets ... Analysis and Strategies - 2016" report to their offering. ... The latest research ... pricing data and benchmarks in the global Oesophageal Cancer market. ... What are the key drugs marketed for Oesophageal Cancer and ...
(Date:2/23/2017)... 2017 AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX), ... and commercialization of innovative therapies for the treatment ... release fourth quarter and yearly financial results after ... management will host an investment-community conference call at ... on March 2 nd 2017 to discuss ...
(Date:2/23/2017)... , February 23, 2017 ... from increasing caseload for varicose veins in their body. ... globe are prompting the adoption of endovenous laser therapy ... global endovenous laser therapy market, published by ... of lifestyle choices and consequences of obesity have collectively ...
Breaking Medicine Technology: